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Lewis Kaufman

  • ASSOCIATE PROFESSOR Medicine, Nephrology
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  • Nephrology

  • American Board of Internal Medicine


  • MD, SUNY at Stony Brook School of Medicine

  • Mount Sinai School of Medicine
    Internal Medicine

  • Mount Sinai School of Medicine

  • Mount Sinai School of Medicine

  • B.A., Columbia University

  • M.D., State University of New York at Stony Brook

  • Residency, Internal Medicine
    Mount Sinai Hospital

  • Fellowship, Nephrology
    Mount Sinai Hospital


Podocyte dysfunction

We study the glomerular podocyte, a critical cell in forming the kidney's ultrafiltration barrier. Podocyte injury occurs in all forms of proteinuric renal disease and is critical in mediating progression of renal failure. We have identified the sidekick gene family as being highly upregulated in podocytes in HIV-associated nephropathy (HIVAN). We have shown that the sidekicks function as homophilic adhesion molecules and that their over-expression in HIVAN alters how adjacent podocytes interact. We are interested in understanding how the sidekicks contribute to renal failure pathogenesis in both HIVAN and in other renal diseases.

Renal development

The sidekicks are highly expressed in many organs during embryogenesis. In the developing kidney, they are expressed throughout the branching ureteric bud. By using an siRNA based approach, we are studying the role of the sidekick proteins during nephrogenesis and how the sidekicks interact with other critical mediators of ureteric bud branching.


Kaufman L, Hayashi K, Ross MJ, Ross MD, Klotman PE. Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy. J Am Soc Nephrol 2004 Jul; 15(7): 1721-30.

Hayashi K, Kaufman L, Ross MD, Klotman PE. Definition of the critical domains required for homophilic targeting of mouse sidekick molecules. FASEB J 2005 Apr; 19(6): 614-6.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Kaufman did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at Patients may wish to ask their physician about the activities they perform for companies.

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