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Lily Ng

  • ADJUNCT ASSISTANT PROFESSOR Genetics and Genomic Sciences
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Research

Thyroid hormone and its receptor genes mediate critically important functions in development and in homeostasis. Our research focuses on characterizing the in vivo functions of the thyroid hormone receptor (TR) genes, using gene targeting and transgenic approaches in the mouse. Mice with an inactivated TRb gene have already been derived, which display defective pituitary function and deafness. To investigate TRb function in more detail, the relative contribution of its two N-terminal splice variants to these function is being examined. These N-terminal variants are differentially expressed and therefore, they may mediate distinct functions in vivo, providing diversity in the tissue-specific responses to thyroid hormone.

Publications

Ng L, Haugen BR, Wood WM, Curran T. N-terminal variants of thyroid hormone receptor b: differential function and potential contribution to syndrome of resistance to thyroid hormone. Mol Endocrinol 1995 Sep; 9(9): 1202-13.

Erway LC, Ng L, Altschuler R, Curran T. Thyroid hormone receptor b is essential for development of auditory function. Nat Genet 1996 Jul; 13(3): 354-7.

Gothe S, Wang Z, Ng L, Kindblom JM, Campos-Barros, Ph.D. A, Ohlsson C, Vennstrom B, Forrest D. Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation. Genes Dev 1999 May 15; 13(10): 1329-41.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr.Ng is not currently required to report Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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