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Matilde Inglese

  • ASSOCIATE PROFESSOR Neurology
  • ASSOCIATE PROFESSOR Radiology
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Education

  • MD, University of Genoa

  • Residency, University of Genoa
    Neurology

  • Neuroimaging Research Unit, San Raffaele Hospital

  • New York University, Radiology Department

  • PhD, University of Genoa

Biography

    Dr. Matilde Inglese is an Associate Professor of Neurology, Radiology and Neuroscience at Mount Sinai School of Medicine. She received her medical degree magna cum laude from the University of Genoa, Italy and earned a PhD degree from the same university after her formal training in neurology. Dr. Inglese completed her post-doctoral training in Neuroimaging at San Raffaele Hospital, Milan, Italy. Then, supported by the National Multiple Sclerosis Society, Dr. Inglese completed a fellowship in neuroimaging at New York University.

    Her current research, supported by the National Institute of Health, focuses on the development and application of new structural and functional magnetic resonance imaging techniques at high and ultra-high field strength, to study multiple sclerosis and other neurological diseases. This work aims to identify the mechanisms of degeneration which lead to the accumulation of irreversible clinical disability, and to provide surrogate markers to monitor the efficacy of neuroprotective treatments in vivo.

    Dr. Inglese serves as a member of the National Institute of Health study sections, and she is a member of the American Academy of Neurology and the International Society of Magnetic Resonance in Medicine. Dr. Inglese is author and co-author of several original contributions published in the neurological and radiological scientific literature and several book chapters on clinical and basic research aspects of multiple sclerosis.

Research

Novel MRI Markers of Progressive Multiple Sclerosis

Recent brain pathology studies have shown that patients with progressive MS present a pattern of extensive cortical demyelination and more diffuse injury of normal-appearing white matter. Using novel MRI techniques such as double inversion recovery, diffusional kurtosis and perfusion imaging, we are measuring cortical lesions and microstructural and metabolic gray matter injury in patients with primary progressive MS. Also, we are investigating the role of gray matter injury in development of brain atrophy and cognitive deficits. 

Non-invasive Brain Sodium Quantification in Multiple Sclerosis

It has been suggested that the accumulation of intra-axonal sodium represents a key factor in the degenerative process of MS. Changes in  tissue sodium concentration can be measured in vivo by single quantum Sodium MR Imaging. The application of triple quantum sodium filtration, allows the measurement of intracellular sodium concentration. Using ultra-high field MRI (7T) in collaboration with the Center for Biomedical Imaging at NYU we are investigating whether sodium-related brain tissue damage is critical for the accumulation of clinical disability in MS

Publications

Inglese M, Ge Y, Filippi M, Falini A, Grossman RI, Gonen O. Indirect evidence for early widespread gray matter involvement in relapsing-remitting multiple sclerosis. NeuroImage 2004 Apr; 21(4).

Inglese M, Liu S, Babb JS, Mannon LJ, Grossman RI, Gonen O. Three-dimensional proton spectroscopy of deep gray matter nuclei in relapsing-remitting MS. Neurology 2004 Jul; 63(1).

Filippi M, Rovaris M, Inglese M, Barkhof F, De Stefano N, Smith S, Comi G. Interferon beta-1a for brain tissue loss in patients at presentation with syndromes suggestive of multiple sclerosis: a randomised, double-blind, placebo-controlled trial. Lancet; 364(9444).

Adhya S, Johnson G, Herbert J, Jaggi H, Babb JS, Grossman RI, Inglese M. Pattern of hemodynamic impairment in multiple sclerosis: dynamic susceptibility contrast perfusion MR imaging at 3.0 T. NeuroImage 2006 Dec; 33(4).

Inglese M, Park SJ, Johnson G, Babb JS, Miles L, Jaggi H, Herbert J, Grossman RI. Deep gray matter perfusion in multiple sclerosis: dynamic susceptibility contrast perfusion magnetic resonance imaging at 3 T. Archives of neurology 2007 Feb; 64(2).

Inglese M, Adhya S, Johnson G, Babb JS, Miles L, Jaggi H, Herbert J, Grossman RI. Perfusion magnetic resonance imaging correlates of neuropsychological impairment in multiple sclerosis. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008 Jan; 28(1).

Inglese M, Rusinek H, George IC, Babb JS, Grossman RI, Gonen O. Global average gray and white matter N-acetylaspartate concentration in the human brain. NeuroImage 2008 Jun; 41(2).

Bakshi R, Thompson AJ, Rocca MA, Pelletier D, Dousset V, Barkhof F, Inglese M, Guttmann CR, Horsfield MA, Filippi M. MRI in multiple sclerosis: current status and future prospects. Lancet neurology 2008 Jul; 7(7).

Inglese M, Madelin G, Oesingmann N, Babb JS, Wu W, Stoeckel B, Herbert J, Johnson G. Brain tissue sodium concentration in multiple sclerosis: a sodium imaging study at 3 tesla. Brain : a journal of neurology 2010 Mar; 133(Pt 3).

Fleysher L, Oesingmann N, Inglese M. B₀ inhomogeneity-insensitive triple-quantum-filtered sodium imaging using a 12-step phase-cycling scheme. NMR in biomedicine 2010 Dec; 23(10).

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Below are financial relationships with industry reported by Dr. Inglese during 2013 and/or 2014. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Scientific Advisory Board:

  • Vaccinex Inc.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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