Matthew A Levin, MD
- ASSOCIATE PROFESSOR | Anesthesiology, Perioperative & Pain Medicine
- ASSOCIATE PROFESSOR | Genetics and Genomic Sciences
Research Topics:Bioinformatics, Genomics
Dr. Levin is a Board Certified Cardiac Anesthesiologist, Board Certified Clinical Informaticist, and the Director of Research Informatics in the Department of Anesthesiology. His research interest lies in leveraging large data sets of intraoperative physiological data to reduce morbidity and mortality and enhance patient safety during the perioperative period. Over the past several years he has designed and implemented a large perioperative data warehouse containing detailed pre-, post-, and intra-operative information, including high resolution physiological data captured from intraoperative monitoring devices, for over 700,000 surgical cases. This anesthesia data warehouse continues to grow at a rate of 50,000 cases per year as new case data is automatically added on a real time basis.
Through his multi-disciplinary collaborations with other researchers in the Icahn School of Medicine, Dr. Levin is pushing the boundaries of perioperative research in order to answer previously un-addressable questions on the phenotype and genotype of the response to anesthetic and surgical stress. Dr. Levin is affiliated with The Charles Bronfman Institute for Personalized Medicine and collaborates closely with fellow IPM member Dr. Eimear Kenny. Together they were recently awarded a prestigious starter grant from the Society of Cardiovascular Anesthesiologists to investigate the Genomics of Vasoplegia, a condition of profound, persistent hypotension sometimes seen after cardiopulmonary bypass. Dr. Levin has also been leading an initiatives to build a real-time, streaming data pipeline that uses machine learning to improve the early detection of unexpected deteriorations in clinical status among inpatients and provide real-time alerting to clinicians.
Dr. Levin's 2014 article "Low intraoperative tidal volume ventilation with minimal PEEP is associated with increased mortality" was recently recognized as the most cited article from 2013-2014 in the British Journal of Anaesthesia, contributing to the BJA's increase in impact factor to 5.616.
American Board of Anesthesiology
MD, Mount Sinai School of Medicine
BS, Massachusetts Institute of Technology
Internship, Surgery, Lenox Hill Hospital
Residency, Anesthesiology, Mount Sinai Hospital
Fellowship, Cardiothoracic Anes., Mount Sinai Hospital
Starter Grant - Genomics of Vasoplegia
Dr. Levin is investigating the genomic basis of vasoplegia - a state of profound, refractory hypotension often seen in patients undergoing cardiac surgery.
Levin MA, Joseph TT, Jeff JM, Nadukuru R, Ellis SB, Bottinger EP, Kenny EE. iGAS: A framework for using electronic intraoperative medical records for genomic discovery. Journal of biomedical informatics 2017 Mar; 67.
Levin MA, McCormick PJ, Lin HM, Hosseinian L, Fischer GW. Low intraoperative tidal volume ventilation with minimal PEEP is associated with increased mortality. British journal of anaesthesia 2014 Jul; 113(1).
Mandel-Portnoy Y, Levin MA, Bansilal S, Suprun M, Lin HM, Richardson LD, Fischer GW, Halperin JL. Low intraoperative heart rate volatility is associated with early postoperative mortality in general surgical patients: a retrospective case-control study. Journal of clinical monitoring and computing 2015 Oct;.
Levin MA, Fischer GW, Lin HM, McCormick PJ, Krol M, Reich DL. Intraoperative arterial blood pressure lability is associated with improved 30 day survival. British journal of anaesthesia 2015 Nov; 115(5).
Levin MA, Krol M, Doshi AM, Reich DL. Extraction and mapping of drug names from free text to a standardized nomenclature. AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium 2007;.
Levin MA, Lin HM, Castillo JG, Adams DH, Reich DL, Fischer GW. Early on-cardiopulmonary bypass hypotension and other factors associated with vasoplegic syndrome. Circulation 2009 Oct; 120(17).
Fischer GW, Levin MA. Vasoplegia during cardiac surgery: current concepts and management. Seminars in thoracic and cardiovascular surgery 2010; 22(2).
Phillips AT, Deiner S, Mo Lin H, Andreopoulos E, Silverstein J, Levin MA. Propofol Use in the Elderly Population: Prevalence of Overdose and Association With 30-Day Mortality. Clinical therapeutics 2015 Dec; 37(12).
Levin MA, Wanderer JP, Ehrenfeld JM. Data, Big Data, and Metadata in Anesthesiology. Anesthesia and analgesia 2015 Dec; 121(6).
Hosseinian L, Weiner M, Levin MA, Fischer GW. Methylene Blue: Magic Bullet for Vasoplegia?. Anesthesia and analgesia 2016 Jan; 122(1).
Hosseinian L, Levin MA, Fischer GW, Anyanwu AC, Torregrossa G, Evans AS. Hemodynamic deterioration during extracorporeal membrane oxygenation weaning in a patient with a total artificial heart. Critical care medicine 2015 Jan; 43(1).
Levin MA, Anyanwu AC, Eggert CA, Mittnacht AJ. Use of an automatic internal defibrillator to induce and maintain ventricular fibrillation during left ventricular assist device pump exchange. The Journal of thoracic and cardiovascular surgery 2014 Mar; 147(3).