Photo of Merle (Menachem) Fromer

Merle (Menachem) Fromer

  • ASSISTANT PROFESSOR Psychiatry
  • ASSISTANT PROFESSOR Genetics and Genomic Sciences
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Biography

    Menachem Fromer is a computational biologist, computer scientist, and geneticist investigating the genetic causes of psychiatric disorders, including schizophrenia, autism, and bipolar disorder. His previous work has yielded efficient algorithms for processing large datasets of protein sequences and clustering them into functional groups and families, accurate algorithms for modeling protein structures and protein-protein interactions at the atomic level, and general-purpose algorithms for finding multiple optimal solutions for widely-used mathematical models.

Research

The current focus of Menachem’s research is in developing computational tools to analyze (exome) sequencing data of large samples of thousands of schizophrenia patients in order to uncover genetic variation, in particular structural variation. His main projects include detecting copy number variation (XHMM software) from exome resequecing data, in addition to sequencing-based phasing of haplotype information. Furthermore, he is studying schizophrenia trios (proband and parents) that are being exome sequenced to discover de novo coding mutations ranging from single-nucleotide variants, insertions/deletions, and copy number variation.  He is also collaborating with a number of researchers on developing novel tools for integrating genetic findings into known biological pathways and other functional data, for example, protein-protein interaction networks and protein family and domain information.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Fromer did not report having any of the following types of financial relationships with industry during 2013 and/or 2014: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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