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Panagiotis Roussos

  • ASSISTANT PROFESSOR Genetics and Genomic Sciences
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  • MD, University of Crete Medical School

  • Residency, Psychiatry
    Mount Sinai School of Medicine

  • Fellowship, Schizophrenia
    Mount Sinai School of Medicine


    Panos Roussos is an Assistant Professor of Psychiatry and Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai. He is a member of Icahn Institute - Genomics and Multiscale Biology and Friedman Brain Institute. He is also a VA/MIRECC Research Physician at the James J. Peters VA Medical Center.

    Panos Roussos received his medical and doctorate degrees from the University of Crete in Greece. He completed his residency in Psychiatry (research track) at Icahn School of Medicine at Mount Sinai followed by a MIRECC research fellowship in schizophrenia.


  • 2013 -
    Young Investor Award

  • 2012 -
    Early Academic Career Award

  • 2010 -
    Outstanding Resident Award
    National Institute of Mental Health


Panos Roussos's research is focused on discerning the neurobiology of neuropsychiatric illnesses through understanding the regulation of gene expression. He applies a combination of Molecular Biology and Bioinformatics approaches to tackle these questions.


Roussos P, Giakoumaki SG, Bitsios P. Tolcapone effects on gating, working memory, and mood interact with the synonymous catechol-O-methyltransferase rs4818c/g polymorphism. Biological psychiatry 2009 Dec; 66(11).

Roussos P, Katsel P, Davis KL, Bitsios P, Giakoumaki SG, Jogia J, Rozsnyai K, Collier D, Frangou S, Siever LJ, Haroutunian V. Molecular and genetic evidence for abnormalities in the nodes of Ranvier in schizophrenia. Archives of general psychiatry 2012 Jan; 69(1).

Roussos P, Katsel P, Davis KL, Siever LJ, Haroutunian V. A system-level transcriptomic analysis of schizophrenia using postmortem brain tissue samples. Archives of general psychiatry 2012 Dec; 69(12).

Roussos P. Transcription factor 4 as an important determinant of gating function in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America 2012 Apr; 109(16).

Roussos P, Katsel P, Davis KL, Giakoumaki SG, Lencz T, Malhotra AK, Siever LJ, Bitsios P, Haroutunian V. Convergent findings for abnormalities of the NF-κB signaling pathway in schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2013 Feb; 38(3).

Kozlenkov A, Roussos P, Timashpolsky A, Barbu M, Rudchenko S, Bibikova M, Klotzle B, Byne W, Lyddon R, Di Narzo AF, Hurd YL, Koonin EV, Dracheva S. Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites. Nucleic acids research 2014 Jan; 42(1).

Purcell SM, Morgan JL, Fromer M, Ruderfer D, Solovieff N, Roussos P, O'Dushlaine C, Chambert K, Bergen SE, Kahler A, Duncan L, Stahl E, Genovese G, Fernandez E, Collins MO, Komiyama NH, Choudhary JS, Magnusson PK, Banks E, Shakir K, Garimella K, Fennell T, de Pristo M, Grant S, Haggarty S, Gabriel S, Scolnik EM, Lander ES, Hultman C, Sullivan P, Carroll S, Sklar P. A burden of ultra-rare disruptive mutations concentrated in synaptic gene networks increases risk of schizophrenia. Nature 2014;.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Roussos did not report having any of the following types of financial relationships with industry during 2014 and/or 2015: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

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