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Paula Busse

  • ASSOCIATE PROFESSOR Medicine, Clinical Immunology
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Certifications

  • American Board of Allergy & Immunology

Education

  • MD, University of Rochester School of Medicine & Dentistry

  • Residency, Internal Medicine
    Mount Sinai Hospital

  • Fellowship, Clinical Immunology
    Mount Sinai Hospital

Biography

    Paula J. Busse MD is an Associate Professor in the Department of Medicine, Division of Clinical Immunology.  She received her undergraduate education at Wellesley College and her medical degree from the University of Rochester.  She completed her medical residency training in Internal Medicine and her post-doctorate training in Allergy and Immunology at the Mount Sinai School of Medicine, where she also completed a graduate clinical research training program.  Her clinical and research areas of interest are asthma in older patients and treatment of hereditary angioedema.  Dr. Busse is funded by the National Institutes of Health and several foundation grants.   She is active in the American Academy of Allergy, Asthma and Immunology, giving lectures at national and local meetings and is involved in several of its committees.  She has been elected to the Hereditary Angioedema Association Scientific Medical Advisory Board.  She has been a small group discussion leader for the first-year medical student basic immunology course for several years. 

Awards

  • -
    New award

  • 2008 -
    Allergy, Asthma and Immunology Education and Research Trust/Journal of Clinical Immunology Research Award

  • 2003 -
    Dr. Solomon Silver Award
    Clinical Medicine (MSH)

  • 2003 - 2005
    T. Franklin Williams Scholar Award

  • 2002 -
    ACAAI Young Faculty Award

Research

Asthma in older patients

Asthma morbidity and mortality is highest in patients >65 years old, and underlying airway inflammation in this age group has not been characterized.  In this laboratory, we have studied a model of asthma in aged mice and have investigated whether age alters modulation of airway inflammation.  Presently, the laboratory is translating these studies to evaluate clinical characteristics of asthma in older patients and markers of inflammation in the airways of these patients.  This knowledge will help to direct age-specific anti-inflammatory asthma therapy.

 

Hereditary Angioedema (HAE) 

HAE is a rare disease which affects approximately 4,000 people in the US.  Its symptoms include swelling of the face, airway, extremities and abdomen.  If swelling involves the airways, it can be life-threatening.  Our group has been involved in several clinical trials for new medications to treat HAE.  In addition, the laboratory is presently studying mechanisms by whichestrogen can exacerbate HAE. 


Selected publications

 

Zuraw BL, Banerji A, Bernstein JA, Busse PJ, Christiansn SC, Davis-Lorton M, Frank MM, Li HH, Lumry WR, Riedl M.  US Hereditary Angioedema Association Medical Advisory Board 2013 Recommendation for the management of Hereditary Angioedema due to C1 Inhibitor deficiency.  J Allergy and Clin Immunol:  In Practice 2013; 1 (6): 458-467.

Birmingham JM, Patil S, Li XM, Busse PJ.  The effect of oral tolerance on the allergic airway response in young and aged mice.  J Asthma 2013: 50 (2): 122-32.

Busse PJ, Cohn RD, Salo PM, Zeldin DL. Characteristics of allergic sensitization among adult asthmatics >55 years:  Results from the National Health and Nutrition Examination Survey 2005-2006.  Ann Allergy Asthma Immunol 2013; 110 (4) 247-52.

Riedl MA, Hurewitz DS, Levy R, Busse PJ, Fitts D, Kalfus I.  Nanofiltered C1 esterase inhibitor (human) for the treatment of acute attacks of hereditary angioedema: an open-label trial.  Ann Allergy Asthma Immunol 2012; 108: 49-53.

Busse PJ, Lurshurchadia L, Sampson H, Halm EA, Wisnivesky J.  Perennial allergen-specific immunoglobulin E levels among inner-city elderly asthmatics.  J Asthma 2010; 47 (7): 781-5.

Zuraw BL, Busse PJ, White M,  et al. Nanofiltered C1 Inhibitor Concentrate for treatment of hereditary angioedema.  NEJM 2010; 363 (6): 513-22.

 Busse PJ, Schofield B, Birmingham N, Yang N, Wen MC, Zhang T, Srivastava K, Li XM.   The traditional Chinese Herbal Formula, ASHMI, inhibits allergic lung inflammation in antigen-sensitized and antigen-challenged aged mice.  Ann Allergy Asthma Immunol 2010; 104 (3): 236-246.

 Busse PJ, Zhang TF, Schofield B, Kilaru K, Patil S, Li XM.  Decrease in airway mucous gene expression caused by treatment with anti-tumor necrosis factor alpha in a murine model of allergic asthma.   Ann Allergy Asthma Immunol 2009; 103 (4): 295-303.

 Busse PJ, Zhang, TF, Srivastava K, Schofield B, Li XM. Effect of ageing on pulmonary inflammation, airway hyperresponsiveness and T and B cell responses in antigen-sensitized and -challenged mice.  Clin Exp Allergy  2007; 37 (9): 1392-1403.

 Clinical trials

 Anti IL-5 (Mepolizumab) treatment in hypereosinophilic syndrome

 Consulting

 CSL Behring, Viropharma/Shire, Dyax Corp, Gerson Lehrman Group

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Below are financial relationships with industry reported by Dr. Busse during 2012 and/or 2013. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Consulting:

  • CSL Behring; Gerson Lehrman Group; ViroPharma Incorporated

Scientific Advisory Board:

  • Dyax Corp.; Shire

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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Tel: 212-659-9262
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Department of Medicine - Allergy & Immunology

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