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Peter Rudebeck

  • ASSISTANT PROFESSOR Neuroscience
  • ASSISTANT PROFESSOR Psychiatry
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Training Areas

Education

  • PhD, University of Oxford

Biography

    Dr Rudebeck joined the department of Neuroscience at the Icahn School of Medicine at Mount Sinai in 2014 as an Assistant Professor. His training and background are in neuropsychology and neurophysiology. He obtained his PhD in Experimental Psychology from the University of Oxford, where he investigated the role of the prefrontal cortex in emotion, social behavior and decision-making. Prior to joining the faculty at Mount Sinai, Dr Rudebeck was a Research Fellow at the National Institute of Mental Health (NIMH), in Bethesda, Maryland. While at the NIMH, his research focused on how interaction between the prefrontal cortex and other parts of the brain, such as the amygdala, contributes to emotion and cognition. At the Icahn School of Medicine, Dr Rudebeck’s lab will investigate the neural systems involved in emotion and decision-making using a combination of behavioral, neurophysiology and interference techniques.

Awards

  • 2009 - 2011
    Julius Axelrod Memorial Fellowship
    National Insitute of Mental Health

Research

Neurobiology of Emotion and Cognition

In our daily lives we often encounter both pleasurable and aversive situations, which heighten our emotional state and affect cognition. The ability to flexibly regulate our emotions in response to such events is essential for adapting to our environment and, ultimately, for our mental health. Many forms of mental illness involve dysfunction in the neural systems that regulate affective processing. The limbic system, which includes parts of the prefrontal cortex and medial temporal lobe, is critical for regulating emotions and plays an essential role in cognition. The main focus of the Rudebeck lab is to understand how the limbic system, specifically the amygdala and ventromedial prefrontal cortex, contribute to emotional regulation and decision-making. To do this, we use a combination of behavioral, autonomic, neurophysiological and lesion approaches in animal models.   

Publications

Rudebeck PH, Putnam PT, Daniels TE, Yang T, Mitz AR, Rhodes SE, Murray EA. A role for primate subgenual cingulate cortex in sustaining autonomic arousal. Proceedings of the National Academy of Sciences of the United States of America 2014 Apr; 111(14).

Rudebeck PH, Mitz AR, Chacko RV, Murray EA. Effects of amygdala lesions on reward-value coding in orbital and medial prefrontal cortex. Neuron 2013 Dec; 80(6).

Rudebeck PH, Saunders RC, Prescott AT, Chau LS, Murray EA. Prefrontal mechanisms of behavioral flexibility, emotion regulation and value updating. Nature Neuroscience 2013 Aug; 16(8).

Izquierdo A, Darling C, Manos N, Pozos H, Kim C, Ostrander S, Cazares V, Stepp H, Rudebeck PH. Basolateral amygdala lesions facilitate reward choices after negative feedback in rats. The Journal of Neuroscience 2013 Feb; 33(9).

Rudebeck PH, Murray EA. Dissociable effects of subtotal lesions within the macaque orbital prefrontal cortex on reward-guided behavior. The Journal of Neuroscience 2011 Jul; 31(29).

Walton ME, Behrens TE, Buckley MJ, Rudebeck PH, Rushworth MF. Separable learning systems in the macaque brain and the role of orbitofrontal cortex in contingent learning. Neuron 2010 Mar; 65(6).

Rudebeck PH, Behrens TE, Kennerley SW, Baxter MG, Buckley MJ, Walton ME, Rushworth MF. Frontal cortex subregions play distinct roles in choices between actions and stimuli. The Journal of Neuroscience 2008 Dec; 28(51).

Rudebeck PH, Murray EA. Amygdala and orbitofrontal cortex lesions differentially influence choices during object reversal learning. The Journal of Neuroscience 2008 Aug; 28(33).

Rushworth MF, Behrens TE, Rudebeck PH, Walton ME. Contrasting roles for cingulate and orbitofrontal cortex in decisions and social behaviour. Trends in Cognitive Sciences 2007 Apr; 11(4).

Rudebeck PH, Buckley MJ, Walton ME, Rushworth MF. A role for the macaque anterior cingulate gyrus in social valuation. Science 2006 Sep; 313(5791).

Rudebeck PH, Walton ME, Smyth AN, Bannerman DM, Rushworth MF. Separate neural pathways process different decision costs. Nature Neuroscience 2006 Sep; 9(9).

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Rudebeck did not report having any of the following types of financial relationships with industry during 2013 and/or 2014: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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