Photo of Rauf Latif

Rauf Latif

  • ASSOCIATE PROFESSOR Medicine, Endocrinology, Diabetes and Bone Disease
Print ProfilePrint Profile

Education

  • Ph.D., Institute of Basic Medical Sciences

  • Indian Institute of Science

  • Weizmann Institute of Science

Awards

  • 2003 -
    Travel Award
    The Endocrine Society

  • 2000 -
    Travel Award
    The American Thyroid Association

  • 1986 -
    Five year Predoctoral Fellowship
    University Grants Commission, India

Research

The thyroid stimulating hormone receptor (TSHR) expressed on the plasma membrane of thyroid epithelial cells is central to the regulation of thyroid growth development and function. This unique glycoprotein hormone receptor undergoes complex post-translational processing such as intra-molecular cleavage and homo-oligomerization. Gaining insight into the regulation and signaling of this thyroid autoantigen is important because of its extended role in other extra-thyroidal tissues. Thus receptor regulations is important in thyroid autoimmune diseases, thyroid development and other extra-thyroidal pathophysiological conditions.


My focus has been on understanding the role of these receptor post-translational modifications on regulation and signaling using both biochemical and biophysical approaches by employing various GFP tagged and untagged receptors. Additionally, we also develop cell-based tools to discover novel molecules as drug targets against this receptor.

Publications

Latif R, Ali MR, Ma R, David M, Morshed S, Ohlmeyer M, Felsenfeld DP, Lau Z, Mezei M, Davies TF. NEW SMALL MOLECULE AGONISTS TO THE TSH RECEPTOR. Thyroid : official journal of the American Thyroid Association 2014 Oct;.

Ma R, Bonnefond S, Morshed SA, Latif R, Davies TF. Stemness is Derived from Thyroid Cancer Cells. Frontiers in endocrinology 2014; 5.

Ali MR, Latif R, Davies TF, Mezei M. Monte Carlo loop refinement and virtual screening of the thyroid-stimulating hormone receptor transmembrane domain. Journal of biomolecular structure & dynamics 2014 Jul;.

Yin X, Sachidanandam R, Morshed S, Latif R, Shi R, Davies TF. mRNA-Seq Reveals Novel Molecular Mechanisms and a Robust Fingerprint in Graves' Disease. The Journal of clinical endocrinology and metabolism 2014 Oct; 99(10).

Davies TF, Ali MR, Latif R. Allosteric modulators hit the TSH receptor. Endocrinology 2014 Jan; 155(1).

Baliram R, Chow A, Huber AK, Collier L, Ali MR, Morshed SA, Latif R, Teixeira A, Merad M, Liu L, Sun L, Blair HC, Zaidi M, Davies TF. Thyroid and bone: macrophage-derived TSH-β splice variant increases murine osteoblastogenesis. Endocrinology 2013 Dec; 154(12).

Morshed SA, Ma R, Latif R, Davies TF. How one TSH receptor antibody induces thyrocyte proliferation while another induces apoptosis. Journal of autoimmunity 2013 Dec; 47.

Galofré JC, Chacón AM, Latif R. Targeting thyroid diseases with TSH receptor analogs. Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición 2013 Dec; 60(10).

Ma R, Latif R, Davies TF. Thyroid follicle formation and thyroglobulin expression in multipotent endodermal stem cells. Thyroid : official journal of the American Thyroid Association 2013 Apr; 23(4).

Baliram R, Sun L, Cao J, Li J, Latif R, Huber AK, Yuen T, Blair HC, Zaidi M, Davies TF. Hyperthyroid-associated osteoporosis is exacerbated by the loss of TSH signaling. The Journal of clinical investigation 2012 Oct; 122(10).

Morshed SA, Latif R, Davies TF. Characterization of thyrotropin receptor antibody-induced signaling cascades. Endocrinology 2009; 150: 519-529.

Zhu LL, Blair H, Cao J, Yuen T, Latif R, Guo L, Tourkova IL, Li J, Davies TF, Sun L, Bian Z, Rosen C, Zallone A, New MI, Zaidi M. Blocking antibody to the β-subunit of FSH prevents bone loss by inhibiting bone resorption and stimulating bone synthesis. Proceedings of the National Academy of Sciences of the United States of America 2012 Sep; 109(36).

Huber AK, Finkelman FD, Li CW, Concepcion E, Smith E, Jacobson E, Latif R, Keddache M, Zhang W, Tomer Y. Genetically driven target tissue overexpression of CD40: a novel mechanism in autoimmune disease. Journal of immunology (Baltimore, Md. : 1950) 2012 Sep; 189(6).

Latif R, Teixeira A, Michalek K, Ali MR, Schlesinger M, Baliram R, Morshed SA, Davies TF. Antibody protection reveals extended epitopes on the human TSH receptor. PloS one 2012; 7(9).

Yin X, Latif R, Bahn R, Davies TF. Genetic profiling in Graves' disease: further evidence for lack of a distinct genetic contribution to Graves' ophthalmopathy. Thyroid : official journal of the American Thyroid Association 2012 Jul; 22(7).

Morshed SA, Latif R, Davies TF. Delineating the autoimmune mechanisms in Graves' disease. Immunologic research 2012 Dec; 54(1-3).

Baliram R, Latif R, Berkowitz J, Frid S, Colaianni G, Sun L, Zaidi M, Davies TF. Thyroid-stimulating hormone induces a Wnt-dependent, feed-forward loop for osteoblastogenesis in embryonic stem cell cultures. Proceedings of the National Academy of Sciences of the United States of America 2011 Sep; 108(39).

Davies TF, Latif R, Minsky NC, Ma R. Clinical review: The emerging cell biology of thyroid stem cells. The Journal of clinical endocrinology and metabolism 2011 Sep; 96(9).

Ma R, Morshed S, Latif R, Zaidi M, Davies TF. The influence of thyroid-stimulating hormone and thyroid-stimulating hormone receptor antibodies on osteoclastogenesis. Thyroid : official journal of the American Thyroid Association 2011 Aug; 21(8).

Latif R, Michalek K, Davies TF. Subunit interactions influence TSHR multimerization. Molecular endocrinology (Baltimore, Md.) 2010 Oct; 24(10).

Morshed SA, Ando T, Latif R, Davies TF. Neutral antibodies to the TSH receptor are present in Graves' disease and regulate selective signaling cascades. Endocrinology 2010 Nov; 151(11).

Latif R, Michalek K, Morshed SA, Davies TF. A tyrosine residue on the TSH receptor stabilizes multimer formation. PloS one 2010; 5(2).

Latif R, Michalek K, Davies TF. Subunit interactions influence TSHR multimerization. Molecular endocrinology (Baltimore, Md.) 2010 Oct; 24(10).

Davies TF, Yin X, Latif R. The genetics of the thyroid stimulating hormone receptor: history and relevance. Thyroid : official journal of the American Thyroid Association 2010 Jul; 20(7).

Latif R, Ando T, Davies TF. Lipid rafts are triage centers for multimeric and monomeric thyrotropin receptor regulation. Endocrinology 2007; 148: 3164-3175.

Latif R, Michalek K, Morshed SA, Davies TF. A tyrosine residue on the TSH receptor stabilizes multimer formation. PloS one 2010; 5(2).

Morshed SA, Ando T, Latif R, Davies TF. Neutral antibodies to the TSH receptor are present in Graves' disease and regulate selective signaling cascades. Endocrinology 2010 Nov; 151(11).

Ma R, Latif R, Davies TF. Thyrotropin-independent induction of thyroid endoderm from embryonic stem cells by activin A. Endocrinology 2009 Apr; 150(4).

Latif R, Morshed SA, Zaidi M, Davies TF. The thyroid-stimulating hormone receptor: impact of thyroid-stimulating hormone and thyroid-stimulating hormone receptor antibodies on multimerization, cleavage, and signaling. Endocrinology and metabolism clinics of North America 2009 Jun; 38(2).

Michalek K, Morshed SA, Latif R, Davies TF. TSH receptor autoantibodies. Autoimmunity reviews 2009 Dec; 9(2).

Martin AP, Marinkovic T, Canasto-Chibuque C, Latif R, Unkeless JC, Davies TF, Takahama Y, Furtado GC, Lira SA. CCR7 deficiency in NOD mice leads to thyroiditis and primary hypothyroidism. Journal of immunology (Baltimore, Md. : 1950) 2009 Sep; 183(5).

Latif R, Ando T, Daniel S, Davies TF. Localization and Regulation of Thyrotropin Receptors within Lipid Rafts. Endocrinology 2003; 144: 4725-4728.

Ciullo I, Latif R, Graves P, Davies TF. Functional assessment of the thyrotropin receptor-beta subunit. Endocrinology 2003; 144: 3176-3181.

Latif R, Graves P, Davies TF. Ligand-dependent inhibition of oligomerization at the human thyrotropin receptor. J Biol.Chem 2002; 277: 45059-45067.

Ando T, Latif R, Pritsker A, Moran T, Nagayama Y, Davies TF. A monoclonal thyroid-stimulating antibody. J Clin Invest 2002; 110: 1667-1674.

Davies T, Marians R, Latif R. The TSH receptor reveals itself. J.Clin.Invest 2002; 110: 161-164.

Ando T, Latif R, Davies T. Concentration-dependent regulation of thyrotropin receptor function by thyroid-stimulating antibody. JCI 2004; 113: 1589-1595.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Latif did not report having any of the following types of financial relationships with industry during 2013 and/or 2014: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

Edit profile in Sinai Central

Address

Thyroid Research Unit Room 2F-30
James J Peters VA Medical Center
Bronx, NY 10468

Tel: 718-584-9000
Fax: 718-220-6397

Address

Atran Berg Laboratory Building Floor 4
1428 Madison Avenue
New York, NY 10029

Tel: 646-725-1641