Rauf Latif, PhD
img_Rauf Latif
ASSOCIATE PROFESSOR | Medicine, Endocrinology, Diabetes and Bone Disease

The thyroid stimulating hormone receptor (TSHR) expressed on the surface of thyroid epithelial cells is central to the regulation of thyroid growth, development and function. This unique GPCR undergoes complex post-translational processing such as intramolecular cleavage and oligomerization in addition to being localized to lipid rafts. Gaining insight into the regulation and signaling of this thyroid autoantigen is important pathophysiologically because of its extended presence in other extra-thyroidal tissues. Thus TSHR is important in thyroid autoimmunity, thyroid development and other extra-thyroidal conditions

Focus of the laboratory has been on understanding the role of these receptors in post-translational modifications and signaling. The receptors has also been a therapeutic target for the development of novel small molecules.  

 

PhD, Institute of Basic Medical Sciences

Indian Institute of Science

Weizmann Institute of Science

2003

Travel Award

The Endocrine Society

2000

Travel Award

The American Thyroid Association

1986

Five year Predoctoral Fellowship

University Grants Commission, India

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Latif has not yet completed reporting of Industry relationships.

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