Photo of Roberto Sanchez

Roberto Sanchez

  • ASSOCIATE PROFESSOR Structural and Chemical Biology
Print ProfilePrint Profile

Education

  • Ph.D., The Rockefeller University

Biography

    Dr. Sanchez is Director of the Structure-Based Drug Discovery Core of the Experimental Therapeutics Institute.

Research

Computer-Aided Drug Discovery and Design

We are interested in developing and applying computational tools that leverage structural information for the discovery of compounds that have the potential of becoming therapeutics. Under the umbrella of the Experimental Therapeutics Institute (ETI) we work with many groups to identify new small-molecules that target disease-related proteins. Therapeutic areas of interest include cancer, cardiovascular disease, diabetes, and others. The computational work is closely tied to experimental validation in collaboration with biomedical research groups and medicinal chemistry.

Structure-Based Drug Discovery at the ETI

    Publications

    Lin Y, Yoo S, Sanchez R. SiteComp: a server for ligand binding site analysis in protein structures. Bioinformatics (Oxford, England) 2012 Apr; 28(8).

    Zhang G, Sanchez R, Zhou MM. Scaling the druggability landscape of human bromodomains, a new class of drug targets. Journal of medicinal chemistry 2012 Sep; 55(17).

    Ghersi D, Sanchez R. Beyond structural genomics: computational approaches for the identification of ligand binding sites in protein structures. Journal of structural and functional genomics 2011 Jul; 12(2).

    Sanchez R, Zhou MM. The PHD finger: a versatile epigenome reader. Trends in biochemical sciences 2011 Jul; 36(7).

    Zhang Q, Chakravarty S, Ghersi D, Zeng L, Plotnikov AN, Sanchez R, Zhou MM. Biochemical profiling of histone binding selectivity of the yeast bromodomain family. PloS one 2010; 5(1).

    Ghersi D, Sanchez R, Ghersi D, Zeng L, Plotnikov AN, Sanchez R, Zhou MM. EasyMIFS and SiteHound: a toolkit for the identification of ligand-binding sites in protein structures. Bioinformatics (Oxford, England) 2009 Dec; 25(23).

    Sanchez R, Zhou MM. The role of human bromodomains in chromatin biology and gene transcription. Current opinion in drug discovery & development 2009 Sep; 12(5).

    Mobarec JC, Sanchez R, Filizola M. Modern homology modeling of G-protein coupled receptors: which structural template to use?. Journal of medicinal chemistry 2009 Aug; 52(16).

    Ghersi D, Sanchez R, Sanchez R. Improving accuracy and efficiency of blind protein-ligand docking by focusing on predicted binding sites. Proteins 2009 Feb; 74(2).

    Chakravarty S, Godbole S, Zhang B, Berger S, Sanchez R. Systematic analysis of the effect of multiple templates on the accuracy of comparative models of protein structure. BMC structural biology 2008; 8.

    Chakravarty S, Wang L, Sanchez R, Berger S, Sanchez R. Accuracy of structure-derived properties in simple comparative models of protein structures. Nucleic acids research 2005; 33(1).

    Chakravarty S, Sanchez R, Sanchez R. Systematic analysis of added-value in simple comparative models of protein structure. Structure (London, England : 1993) 2004 Aug; 12(8).

    Mujtaba S, He Y, Zeng L, Yan S, Plotnikova O, Sachchidanand , Sanchez R, Zeleznik-Le NJ, Ronai Z, Zhou MM. Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. Molecular cell 2004 Jan; 13(2).

    Jin T, Peng L, Mirshahi T, Rohacs T, Chan KW, Sanchez R, Logothetis DE, Zeleznik-Le NJ, Ronai Z, Zhou MM. The (beta)gamma subunits of G proteins gate a K(+) channel by pivoted bending of a transmembrane segment. Molecular cell 2002 Sep; 10(3).

    Sanchez R, Pieper U, Melo F, Eswar N, Marti-Renom MA, Madhusudhan MS, Mirkovic N, Sali A. Protein structure modeling for structural genomics. Nat Struct Biol 2000 Nov; 7(Suppl): 986-90.

    Sanchez R, Pieper U, Mirkovic N, De Bakker PI, Wittenstein E, Sali A, Mirkovic N, Sali A. MODBASE, a database of annotated comparative protein structure models. Nucleic Acids Res 2000 Jan 1; 28(1): 250-3.

    Sanchez R, Sali A, Mirkovic N, De Bakker PI, Wittenstein E, Sali A. Comparative protein structure modeling. Introduction and practical examples with modeller. Methods Mol Biol 2000; 143: 97-129.

    Sanchez R, Sali A. Large-scale protein structure modeling of the Saccharomyces cerevisiae genome. Proc Natl Acad Sci U S A 1998 Nov 10; 95(23): 13597-602.

    Sanchez R, Sali A. Large-scale protein structure modeling of the Saccharomyces cerevisiae genome. Proc Natl Acad Sci U S A 1998 Nov 10; 95(23): 13597-602.

    Zhang G, Sanchez R, Zhou MM. Scaling the druggability landscape of human bromodomains, a new class of drug targets. Journal of medicinal chemistry 2012 Sep; 55(17).

    Hernandez M, Ghersi D, Sanchez R. SITEHOUND-web: a server for ligand binding site identification in protein structures. Nucleic acids research 2009 Jul; 37(Web Server issue).

    Jin YJ, Cai CY, Mezei M, Ohlmeyer M, Sanchez R, Burakoff SJ. Identification of a novel binding site between HIV type 1 Nef C-terminal flexible loop and AP2 required for Nef-mediated CD4 downregulation. AIDS research and human retroviruses 2013 Apr; 29(4).

    Industry Relationships

    Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

    Dr. Sanchez did not report having any of the following types of financial relationships with industry during 2015 and/or 2016: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

    Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

    Edit profile in Sinai Central

    Address

    Icahn (East) Building Floor 16 Room 20E
    1425 Madison Avenue
    New York, NY 10029

    Tel: 212-659-8648
    Fax: 212-659-8232