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Samuel Sidi

  • ASSISTANT PROFESSOR Developmental and Regenerative Biology
  • ASSISTANT PROFESSOR Medicine, Hematology and Medical Oncology
  • ASSISTANT PROFESSOR Oncological Sciences
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  • B.S./M.S., Paris VII University

  • Ph.D., Max-Planck Institute for Developmental Biology, University of Tubingen, and Paris VI University

  • M.S., Paris VI University
    Molecular and Cellular Genetics

  • Postdoctoral fellowship, Dana-Farber Cancer Institute, Harvard Medical School
    Pediatric Oncology

  • Instructor, Harvard Medical School


  • 2011 - 2014
    Searle Scholar

  • 2009 -
    Claudia Adams Barr Award in Cancer Research

  • 2004 -
    French Foundation for Medical Research (FRM) Scholarship

  • 2003 -
    French Association for Cancer Research (ARC) Scholarship


Cancer target discovery in zebrafish (genetic and chemical-genetic approaches), mechanism of action of targeted therapies, development of molecular diagnostics. For more information, please visit our departmental laboratory website:


Chen CC, Kennedy RD, Sidi S, Look AT, D'Andrea A. CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors. Molecular cancer 2009; 8.

Sidi S, Sanda T, Kennedy RD, Hagen AT, Jette CA, Hoffmans R, Pascual J, Imamura S, Kishi S, Amatruda JF, Kanki JP, Green DR, D'Andrea AA, Look AT. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell 2008 May; 133(5).

Obholzer N, Wolfson S, Trapani JG, Mo W, Nechiporuk A, Busch-Nentwich E, Seiler C, Sidi S, Söllner C, Duncan RN, Boehland A, Nicolson T. Vesicular glutamate transporter 3 is required for synaptic transmission in zebrafish hair cells. The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Feb; 28(9).

Geisler R, Rauch GJ, Geiger-Rudolph S, Albrecht A, van Bebber F, Berger A, Busch-Nentwich E, Dahm R, Dekens MP, Dooley C, Elli AF, Gehring I, Geiger H, Geisler M, Glaser S, Holley S, Huber M, Kerr A, Kirn A, Knirsch M, Konantz M, Küchler AM, Maderspacher F, Neuhauss SC, Nicolson T, Ober EA, Praeg E, Ray R, Rentzsch B, Rick JM, Rief E, Schauerte HE, Schepp CP, Schönberger U, Schonthaler HB, Seiler C, Sidi S, Söllner C, Wehner A, Weiler C, Nüsslein-Volhard C. Large-scale mapping of mutations affecting zebrafish development. BMC genomics 2007; 8.

Sidi S, Look AT. Small molecules thwart crash and burn. Nature chemical biology 2005 Dec; 1(7).

Shin JB, Adams D, Paukert M, Siba M, Sidi S, Levin M, Gillespie PG, Gründer S. Xenopus TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner-ear hair cells. Proceedings of the National Academy of Sciences of the United States of America 2005 Aug; 102(35).

Seiler C, Ben-David O, Sidi S, Hendrich O, Rusch A, Burnside B, Avraham KB, Nicolson T. Myosin VI is required for structural integrity of the apical surface of sensory hair cells in zebrafish. Developmental biology 2004 Aug; 272(2).

Sidi S, Rosa FM. [Mechanotransduction of hemodynamic forces regulates organogenesis]. Médecine sciences : M/S 2004 May; 20(5).

Sidi S, Busch-Nentwich E, Friedrich R, Schoenberger U, Nicolson T. gemini encodes a zebrafish L-type calcium channel that localizes at sensory hair cell ribbon synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Apr; 24(17).

Paukert M, Sidi S, Russell C, Siba M, Wilson SW, Nicolson T, Gründer S. A family of acid-sensing ion channels from the zebrafish: widespread expression in the central nervous system suggests a conserved role in neuronal communication. The Journal of biological chemistry 2004 Apr; 279(18).

Sidi S, Friedrich RW, Nicolson T. NompC TRP channel required for vertebrate sensory hair cell mechanotransduction. Science (New York, N.Y.) 2003 Jul; 301(5629).

Concha ML, Russell C, Regan JC, Tawk M, Sidi S, Gilmour DT, Kapsimali M, Sumoy L, Goldstone K, Amaya E, Kimelman D, Nicolson T, Gründer S, Gomperts M, Clarke JD, Wilson SW. Local tissue interactions across the dorsal midline of the forebrain establish CNS laterality. Neuron 2003 Jul; 39(3).

Sidi S, Goutel C, Peyriéras N, Rosa FM. Maternal induction of ventral fate by zebrafish radar. Proceedings of the National Academy of Sciences of the United States of America 2003 Mar; 100(6).

Willot V, Mathieu J, Lu Y, Schmid B, Sidi S, Yan YL, Postlethwait JH, Mullins M, Rosa F, Peyriéras N. Cooperative action of ADMP- and BMP-mediated pathways in regulating cell fates in the zebrafish gastrula. Developmental biology 2002 Jan; 241(1).

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Sidi did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at Patients may wish to ask their physician about the activities they perform for companies.

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