- ASSISTANT PROFESSOR Medicine, Clinical Immunology
Young Investigator's Award
Crohn's and Colitis Foundation of America
2009 - 2012
Career Development Award : Lymphoid regulation of epithelial barrier function
Crohn's and Colitis Foundation of America
ResearchThe mucosal immune system is governed by a unique set of rules and regulations. The local microenvironment dictates the necessity for these differences. The control of immune responses in the gut is critical for normal mucosal homeostasis in the host. Failure to control such responses has been proposed as one component in the development of Inflammatory Bowel Disease (IBD). The development of Crohn’s disease (CD) and ulcerative colitis (UC), two forms of IBD, is in part due to the aberrant crosstalk between flora-epithelium-lamina propria, this leading to abnormal epithelial cell differentiation, barrier function and subsequent innate and adaptive immune dysfunction. The ability of the mucosal immune system to communicate with the overlying intestinal epithelium has been described in different models. Understanding the normal state will allow us to define the nature of the defects seen in Inflammatory Bowel Disease and potentially develop therapeutic approaches to overcome these defects. Our hypothesis is that abnormalities in mucosal lymphocytes in Crohn's disease and Ulcerative colitis lead to disordered epithelial cell differentiation, barrier function and subsequent innate and adaptive immune dysfunctions.
Dahan S, Rabinowitz KM, Martin AP, Berin MC, Unkeless JC, Mayer L. Notch-1 signaling regulates intestinal epithelial barrier function, through interaction with CD4+ T cells, in mice and humans. Gastroenterology 2011 Feb; 140(2).
Nguyen HT, Dalmasso G, Yan Y, Laroui H, Dahan S, Mayer L, Sitaraman SV, Merlin D. MicroRNA-7 modulates CD98 expression during intestinal epithelial cell differentiation. The Journal of biological chemistry 2010 Jan; 285(2).
Roda G, Dahan S, Mezzanotte L, Caponi A, Roth-Walter F, Pinn D, Mayer L. Defect in CEACAM family member expression in Crohn's disease IECs is regulated by the transcription factor SOX9. Inflammatory bowel diseases 2009 Dec; 15(12).
Dahan S, Roth-Walter F, Martin AP, Arnaboldi P, Mayer L. Lymphoepithelial interactions: a new paradigm. Annals of the New York Academy of Sciences 2009 May; 1165.
Roth-Walter F, Berin MC, Arnaboldi P, Escalante CR, Dahan S, Jensen-Joralim E, Mayer L. Pasteurization of B-lactoglobulin promotes allergic sensitization in mice by enhancing uptake through Peyer's patches. Allergy 2008; 63(7): 882-890.
Dahan S, Roda G, Pinn D, Roth-Walter F, Kamalu O, Martin AP, Mayer L. Epithelial: lamina propria lymphocytes interactions promote epithelial cell differentiation. Gastroenterol 2008; 134: 192-203.
Dahan S, Roth-Walter F, Arnaboldi P, Agarwal S, Mayer L. Epithelial: lymphocytes interactions in the gut. Immunol. Rev 2007; 215: 243-253.
Li H, Nowak-Wegrzyn A, Charlop-Powers Z, Shreffler W, Chehade M, Thomas S, Roda G, Dahan S, Sperber K, Berin MC. Transcytosis of IgE-mediated complexes by CD23a in human intestinal epithelial cells and its role in food allergy. Gastroenterol 2006; 131: 47-58.
Dalmasso G, Loubat A, Dahan S, Calle G, Rampal P. Saccharomyces boulardii prevents TNF induced apoptosis in EHEC-infected human colonic cell line T84. Res. Microbiol 2006; 157: 456-465.
Dahan S, Dalmasso G, Imbert V, Peyron JF, Rampal P, Czerucka D. Saccharomyces boulardii interferes with Enterohaemorrhagic Escherichia coli-induced signaling pathways in T84 cells. Infect. Immun 2003; 71: 766-773.
Dahan S, Busuttil V, Imbert V, Peyron JF, Rampal P, Czerucka D. Enterohaemorrhagic Escherichia coli induce IL-8 production via activation of MAP Kinases and the transcription factors NK-kB and AP-1 in T84 cells. Infect. Immun 2002; 70: 2304-2310.
Czerucka D, Dahan S, Mograbi B, Rossi B, Rampal P. Implication of MAP Kinases in T84 cell responses to EPEC infection. Infect. Immun 2001; 69: 1298-1305.
Czerucka D, Dahan S, Mograbi B, Rossi B, Rampal P. Saccharomyces boulardii preserves barrier function and modulates the signal transduction pathway induced in enteropathogenic Escherichia coli-infected T84 cells. Infect. Immun 2000; 68: 5998-6004.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Dahan did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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