- ASSISTANT PROFESSOR Medicine, Clinical Immunology
Young Investigator's Award
Crohn's and Colitis Foundation of America
2009 - 2012
Career Development Award : Lymphoid regulation of epithelial barrier function
Crohn's and Colitis Foundation of America
ResearchThe mucosal immune system is governed by a unique set of rules and regulations. The local microenvironment dictates the necessity for these differences. The control of immune responses in the gut is critical for normal mucosal homeostasis in the host. Failure to control such responses has been proposed as one component in the development of Inflammatory Bowel Disease (IBD). The development of Crohn’s disease (CD) and ulcerative colitis (UC), two forms of IBD, is in part due to the aberrant crosstalk between flora-epithelium-lamina propria, this leading to abnormal epithelial cell differentiation, barrier function and subsequent innate and adaptive immune dysfunction. The ability of the mucosal immune system to communicate with the overlying intestinal epithelium has been described in different models. Understanding the normal state will allow us to define the nature of the defects seen in Inflammatory Bowel Disease and potentially develop therapeutic approaches to overcome these defects. Our hypothesis is that abnormalities in mucosal lymphocytes in Crohn's disease and Ulcerative colitis lead to disordered epithelial cell differentiation, barrier function and subsequent innate and adaptive immune dysfunctions.
Mathern DR, Laitman LE, Hovhannisyan Z, Dunkin D, Farsio S, Malik TJ, Roda G, Chitre A, Iuga AC, Yeretssian G, Berin MC, Dahan S. Mouse and human Notch-1 regulate mucosal immune responses. Mucosal immunology 2014 Jan;.
Song Y, Dunkin D, Dahan S, Iuga A, Ceballos C, Hoffstadter-Thal K, Yang N, Benkov K, Mayer L, Li XM. Anti-inflammatory effects of the Chinese herbal formula FAHF-2 in experimental and human IBD. Inflammatory bowel diseases 2014 Jan; 20(1).
Laitman LE, Dahan S. Taking inflammatory bowel disease up a Notch. Immunologic research 2012 Dec; 54(1-3).
Dahan S, Rabinowitz KM, Martin AP, Berin MC, Unkeless JC, Mayer L. Notch-1 signaling regulates intestinal epithelial barrier function, through interaction with CD4+ T cells, in mice and humans. Gastroenterology 2011 Feb; 140(2).
Roda G, Dahan S, Mezzanotte L, Caponi A, Roth-Walter F, Pinn D, Mayer L. Defect in CEACAM family member expression in Crohn's disease IECs is regulated by the transcription factor SOX9. Inflammatory bowel diseases 2009 Dec; 15(12).
Dahan S, Roth-Walter F, Martin AP, Arnaboldi P, Mayer L. Lymphoepithelial interactions: a new paradigm. Annals of the New York Academy of Sciences 2009 May; 1165.
Dahan S, Roda G, Pinn D, Roth-Walter F, Kamalu O, Martin AP, Mayer L. Epithelial: lamina propria lymphocytes interactions promote epithelial cell differentiation. Gastroenterol 2008; 134: 192-203.
Dahan S, Roth-Walter F, Arnaboldi P, Agarwal S, Mayer L. Epithelial: lymphocytes interactions in the gut. Immunol. Rev 2007; 215: 243-253.
Dahan S, Dalmasso G, Imbert V, Peyron JF, Rampal P, Czerucka D. Saccharomyces boulardii interferes with Enterohaemorrhagic Escherichia coli-induced signaling pathways in T84 cells. Infect. Immun 2003; 71: 766-773.
Dahan S, Busuttil V, Imbert V, Peyron JF, Rampal P, Czerucka D. Enterohaemorrhagic Escherichia coli induce IL-8 production via activation of MAP Kinases and the transcription factors NK-kB and AP-1 in T84 cells. Infect. Immun 2002; 70: 2304-2310.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Dahan during 2012 and/or 2013. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
- Otsuka Pharmaceutical Co., Ltd.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.
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