Steven J. Burakoff

  • DIRECTOR TISCH CANCER INSTITUTE
  • PROFESSOR Oncological Sciences
  • PROFESSOR Medicine, Hematology and Medical Oncology
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Specialty

Certifications

  • American Board of Internal Medicine

Research Topics

Training Areas

Education

  • MD, Albany Medical College

  • MA (hon.), Harvard University

  • Rockefeller University

  • Harvard Medical School

  • MA, Queens College

  • New York Hospital-Cornell Medical Center

  • Internship, General Medicine
    Cornell Medical Center

  • Residency, General Medicine
    Cornell Medical Center

  • Fellowship, Immunology
    Rockefeller University

Biography

Awards

  • 2009 -
    Lifetime Achievement Award
    American Association of Immunologists

  • 2006 -
    Lynne Cohen Foundation Awardee

  • 2003 -
    Distinguished Alumnus 2003

  • 2002 -
    Theobold Smith Alumni Lecture
    Albany Medical College

  • 2001 -
    ISI Highly Cited Researcher (1980-2000)

  • 2000 -
    Laura and Isaac Perlmutter Professor
    New York University, School of Medicine

  • 1998 -
    Margaret M. Dyson Professor of Pediatrics
    Harvard Medical School

  • 1995 -
    Association of American Physicians

  • 1995 -
    Ted Williams Senior Investigator
    Dana-Farber Cancer Institute

  • 1994 -
    Horizons in Biomedical Research Lecture
    Cleveland Clinic Foundation

  • 1992 -
    David A. Talmadge Lecture
    Colorado Allergy Society

Research

Major Research Interests:

   1. Cellular and molecular immunology;
   2. T cell activation and signal transduction;
   3. Transplantation immunology.

Publications

Jin YJ, Cai CY, Zhang X, Zhang HT, Burakoff SJ. Lysine144, a Ubiquitin Attachment Site in HIV-1 Nef, Is Required for Nef-mediated CD4 Downregulation. J Immunol 2008;.

Sawasdikosol S, Pyarajan S, Alzabin S, Matejovic G, Burakoff SJ. Prostaglandin E2 activates HPK1 activity via a PKA-dependent pathway. J Biol Chem 2007 Nov; 282: 34693-34699.

Mathews JP, Taylor BS, Bader GD, Pyarajan S, Antoniotti M, Chinnaiyan AM, Sander C, Burakoff SJ, Mishra B. From bytes to bedside: data integration and computational biologyfor translational cancer research. PLoS Comput Biol 2007 Feb 23; 3(2): e12.

Fragoso R, Pyarajan S, Irie HY, Burakoff SJ. CD8/Lck transgene is able to drive thymocyte differentiation. J. Immun 2006 Feb 15; 176(4): 2669.

Jin JJ, Yi Cai C, Zhang X, Zhang HT, Hirst JA, Burakoff SJ. HIV Nef-mediated CD4 down-regulation is adaptor protein complex 2 dependent. J. Immun 2006 Feb 15; 176(4): 2669.

Zambricki E, Shigeoka A, Kishimoto H, Sprent J, Burakoff S, Carpenter C, Milford E, McKay D. Signaling T cell survival and death by IL-2 and IL-15. Am J Transplant 2005; 11: 2623-2631.

Su MW, Pyarajan S, Chang JH, Yu CL, Jin YJ, Stierhof YD, Walden P, Burakoff SJ. Fratricide of CD8+ cytotoxic T Lymphocytes is dependent on cellular activation and perforin-mediated killing. Eur J Immunol 2004; 34: 2459-2470.

Frazer-Abel AA, Baksh S, Fosmire SP, Willis D, Pierce AM, Meylemans H, Linthicum DS, Burakoff SJ, Coons T, Bellgrau D. Nicotine activates NFATc2 and prevents cell cycle entry in T cells. J Pharmacol Exp Ther 2004; 311: 758-769.

Friedman JS, Alpdogan O, van den Brink MR, Liu C, Hurwiz D, Boyd A, Kupper TS, Burakoff SJ. Increasing T cell age reduces effector activity but preserves proliferative capacity in a murine allogeneic major histocompatibility complex-mismatched bone marrow transplant model. Biol Blood Marrow Transplant 2004; 10: 448-460.

Friedman JS, Lopez MF, Fleming MD, Rivera A, Martin FM, Welsh ML, Boyd AS, Doctrow SR, Burakoff SJ. SOD2 Deficiently anemia: protein oxidation and altered protein expression reveal targets of damage, stress response and anti -oxidant responsiveness. Blood 2004; 104: 2565-2573.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Below are financial relationships with industry reported by Dr. Burakoff during 2012 and/or 2013. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Scientific Advisory Board:

  • Cold Spring Harbor Laboratory (CSHL)

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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Address

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Tel: 212-659-8959
Fax: 212-241-9244