Steven J Burakoff, MD
- PROFESSOR | Oncological Sciences
- PROFESSOR | Medicine, Hematology and Medical Oncology
Specialties:Hematology-Oncology, Internal Medicine
Research Topic:T Cells
Dr. Burakoff is the Director of The Tisch Cancer Institute at Mount Sinai; Lillian and Henry M. Stratton Professor of Cancer Medicine; Professor of Medicine, Hematology and Medical Oncology; and Professor, Oncological Sciences.
Pushing Frontiers in Complex Cancer Care
American Board of Internal Medicine
Multi-Disciplinary Training AreasCancer Biology [CAB], Immunology [IMM]
MD, Albany Medical College
MA, Queens College
MA (hon), Harvard University
Harvard Medical School
New York Hospital-Cornell Medical Center
Internship, General Medicine, Cornell Medical Center
Residency, General Medicine, Cornell Medical Center
Fellowship, Immunology, Rockefeller University
Lifetime Achievement Award
Lynne Cohen Foundation Awardee
Distinguished Alumnus 2003
Theobold Smith Alumni Lecture
ISI Highly Cited Researcher (1980-2000)
Laura and Isaac Perlmutter Professor
Margaret M. Dyson Professor of Pediatrics
Ted Williams Senior Investigator
Association of American Physicians
Horizons in Biomedical Research Lecture
David A. Talmadge Lecture
Major Research Interests:
1. Cellular and molecular immunology;
2. T cell activation and signal transduction;
3. Transplantation immunology.
Jin YJ, Cai CY, Zhang X, Zhang HT, Burakoff SJ. Lysine144, a Ubiquitin Attachment Site in HIV-1 Nef, Is Required for Nef-mediated CD4 Downregulation. J Immunol 2008;.
Sawasdikosol S, Pyarajan S, Alzabin S, Matejovic G, Burakoff SJ. Prostaglandin E2 activates HPK1 activity via a PKA-dependent pathway. J Biol Chem 2007 Nov; 282: 34693-34699.
Mathews JP, Taylor BS, Bader GD, Pyarajan S, Antoniotti M, Chinnaiyan AM, Sander C, Burakoff SJ, Mishra B. From bytes to bedside: data integration and computational biologyfor translational cancer research. PLoS Comput Biol 2007 Feb 23; 3(2): e12.
Fragoso R, Pyarajan S, Irie HY, Burakoff SJ. CD8/Lck transgene is able to drive thymocyte differentiation. J. Immun 2006 Feb 15; 176(4): 2669.
Jin JJ, Yi Cai C, Zhang X, Zhang HT, Hirst JA, Burakoff SJ. HIV Nef-mediated CD4 down-regulation is adaptor protein complex 2 dependent. J. Immun 2006 Feb 15; 176(4): 2669.
Zambricki E, Shigeoka A, Kishimoto H, Sprent J, Burakoff S, Carpenter C, Milford E, McKay D. Signaling T cell survival and death by IL-2 and IL-15. Am J Transplant 2005; 11: 2623-2631.
Su MW, Pyarajan S, Chang JH, Yu CL, Jin YJ, Stierhof YD, Walden P, Burakoff SJ. Fratricide of CD8+ cytotoxic T Lymphocytes is dependent on cellular activation and perforin-mediated killing. Eur J Immunol 2004; 34: 2459-2470.
Frazer-Abel AA, Baksh S, Fosmire SP, Willis D, Pierce AM, Meylemans H, Linthicum DS, Burakoff SJ, Coons T, Bellgrau D. Nicotine activates NFATc2 and prevents cell cycle entry in T cells. J Pharmacol Exp Ther 2004; 311: 758-769.
Friedman JS, Alpdogan O, van den Brink MR, Liu C, Hurwiz D, Boyd A, Kupper TS, Burakoff SJ. Increasing T cell age reduces effector activity but preserves proliferative capacity in a murine allogeneic major histocompatibility complex-mismatched bone marrow transplant model. Biol Blood Marrow Transplant 2004; 10: 448-460.
Friedman JS, Lopez MF, Fleming MD, Rivera A, Martin FM, Welsh ML, Boyd AS, Doctrow SR, Burakoff SJ. SOD2 Deficiently anemia: protein oxidation and altered protein expression reveal targets of damage, stress response and anti -oxidant responsiveness. Blood 2004; 104: 2565-2573.