- ASSISTANT PROFESSOR Medicine, Infectious Diseases
American Board of Internal Medicine
MD, Mount Sinai School of Medicine
Residency, Internal Medicine
Mount Sinai Hospital
Fellowship, Infectious Disease
Mount Sinai Hospital
- My clinical training is in Infectious Diseases with a specific interest in HIV and my basic science interest is in the biology that underlies chronic HIV infection. HIV is an incurable disease and while antiretroviral therapy is effective at suppressive viremia, long term sequelae of inflammation account for premature aging, higher rates of cardiovascular disease, and neoplasms. My research seeks to identify novel mechanisms of HIV-associated inflammation through membrane signaling.
Basic Science Research Award
Association for Clnical and Translational Science (ACTS)/American Federation for Medical Resarch (AFMR) 2014 Translational Science 2014 Annual Meeting
Basic Science Research Award
Infectious Diseases Society of New York
Alpha Omega Alpha Post-Graduate Award
Alpha Omega Alpha Honor Medical Society
Young Investigator Award
Conference of Retroviruses and Opportunistic Infections, Atlanta, GA
Fellow Member of Alpha Omega Alpha
Lambda Chapter, Mount Sinai School of Medicine
Housestaff Excellence in Teaching Award
Institute for Medical Education, Mount Sinai School of Medicine
HIV infection and purinergic signalingI am interested in understanding the mechanisms that underlie chronic inflammation that causes morbidity and mortality in well-controlled HIV-infected patients. Our laboratory research focuses on the role of purinergic signaling that is required for HIV infection and may activate pro-inflammatory cytokine production.
Morino M, Natsui S, Ono T, Swartz TH, Krulwich TA, Ito M. Single site mutations in the hetero-oligomeric Mrp antiporter from alkaliphilic Bacillus pseudofirmus OF4 that affect Na+/H+ antiport activity, sodium exclusion, individual Mrp protein levels, or Mrp complex formation. The Journal of biological chemistry 2010 Oct; 285(40).
Morino M, Natsui S, Swartz TH, Krulwich TA, Ito M. Single gene deletions of mrpA to mrpG and mrpE point mutations affect activity of the Mrp Na+/H+ antiporter of alkaliphilic Bacillus and formation of hetero-oligomeric Mrp complexes. Journal of bacteriology 2008 Jun; 190(12).
Swartz TH, Ito M, Ohira T, Natsui S, Hicks DB, Krulwich TA. Catalytic properties of Staphylococcus aureus and Bacillus members of the secondary cation/proton antiporter-3 (Mrp) family are revealed by an optimized assay in an Escherichia coli host. Journal of bacteriology 2007 Apr; 189(8).
Liu J, Xue Y, Wang Q, Wei Y, Swartz TH, Hicks DB, Ito M, Ma Y, Krulwich TA. The activity profile of the NhaD-type Na+(Li+)/H+ antiporter from the soda Lake Haloalkaliphile Alkalimonas amylolytica is adaptive for the extreme environment. Journal of bacteriology 2005 Nov; 187(22).
Swartz TH, Ikewada S, Ishikawa O, Ito M, Krulwich TA. The Mrp system: a giant among monovalent cation/proton antiporters?. Extremophiles : life under extreme conditions 2005 Oct; 9(5).
Swartz TH, Ito M, Hicks DB, Nuqui M, Guffanti AA, Krulwich TA. The Mrp Na+/H+ antiporter increases the activity of the malate:quinone oxidoreductase of an Escherichia coli respiratory mutant. Journal of bacteriology 2005 Jan; 187(1).
Swartz TH, Huprikar S, Labombardi V, Pinney S, Anyanwu A, Lee M, Patel G. Heart transplantation in a patient with heteroresistant vancomycin-intermediate Staphylococcus aureus ventricular assist device mediastinitis and bacteremia. Transplant infectious disease : an official journal of the Transplantation Society 2013 Oct; 15(5).
Swartz TH, Lin JJ. A clinical refresher course for medical scientist trainees. Medical teacher 2014 Jun; 36(6).
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Swartz did not report having any of the following types of financial relationships with industry during 2014 and/or 2015: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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