Thomas Kraus, PhD
- ASSISTANT PROFESSOR | Obstetrics, Gynecology and Reproductive Science
- ASSISTANT PROFESSOR | Microbiology
The maternal immune system must adapt to allow for the acceptance of the fetal tissue during implantation and throughout gestation. An inappropriate immune response to the fetus or to paternal antigens might result in infertility, failures of implantation, pre-term labor or other complications during gestation.
There is also evidence to suggest that an inappropriate maternal immune response to a virus during pregnancy can affect the fetal environment profoundly. Because of this, viral immunity during the later stages of pregnancy appears to be altered, leaving the mother more susceptible to viral infections.
With a background in mucosal immunology and virology, Dr. Kraus is studying the maternal immune response during pregnancy to the influenza vaccine. Other research interests include the general modulation in the maternal innate and adaptive immune response during the hormonal spikes that accompany different stages of gestation.
Pazos M, Kraus T, Moran T, Munoz-Fontela C. Estrogen Mediates Innate and Adaptive Immune Alterations to Influenza Infection in Pregnant Mice. PLoS ONE;.
Pazos M, Sperling R, Moran T, Kraus T. The influence of pregnancy on systemic immunity. [review]. Immunol Res 2012 March 24;.
Kraus TA, Engel SM, Sperling RS, Kellerman L, Yo Y, Wallenstein S, Escribese MM, Garrido J, Singh T, Loubeau M, Moran TM. Characterizing the pregnancy immune phenotype: Results of the Viral Immunity and Pregnancy (VIP) study. Journal of Clinical Immunology 2011;.
Sperling RS, Engel SM, Wallenstein S, Kraus TA, Garrido J, Singh T, Kellerman L, Moran TM. Immunogenicity of Trivalent Inactivated Influenza Vaccination Received During Pregnancy or Post-partum. Obstetrics & Gynecology 2011;.
Kraus TA, Sperling RS, Engel SM, Lo Y, Kellerman L, Singh T, Loubeau M, Ge Y, Garrido JL, Rodríguez-García M, Moran TM. Peripheral blood cytokine profiling during pregnancy and post-partum periods. American Journal of Reproductive Immunology (New York, N.Y. : 1989) 2010 Dec; 64(6).
Escribese MM, Kraus T, Rhee E, Fernandez-Sesma A, López CB, Moran TM, Kellerman L, Moran TM. Estrogen inhibits dendritic cell maturation to RNA viruses. Blood 2008 Dec; 112(12).
Kraus TA, Garza L, Horvath CM. Enabled interferon signaling evasion in an immune-competent transgenic mouse model of parainfluenza virus 5 infection. Virology 2008 Feb; 371(1).
Yount JS, Kraus TA, Horvath CM, Moran TM, López CB. A novel role for viral-defective interfering particles in enhancing dendritic cell maturation. Journal of immunology (Baltimore, Md. : 1950) 2006 Oct; 177(7).
Kraus Ta, Cheifetz A, Toy L, Meddings J, Mayer L. Evidence for a genetic defect in oral tolerance induction in inflammatory bowel disease. Inflamm Bowel Dis 2006; 12.
Kraus TA, Brimnes J, Muong C, Liu JH, Moran TM, Tappenden KA, Boros P, Mayer L. Mucosal Tolerance Induction in Peyer's Patch-Deficient, Ligated Small Bowel Loops. J. Clin. Invest 2005; 115.
Safadi R, Alvarez CE, Ohta M, Brimnes J, Kraus T, Mehal W, Bromberg J, Mayer L, Friedman SL. Enhanced oral tolerance in transgenic mice with hepatocyte secretion of IL-10 . J Immunol 2005; 175.
Kraus TA, Mayer L. Oral tolerance and inflammatory bowel disease. Current opinion in gastroenterology 2005 Nov; 21(6).
Kraus TA, Toy L, Chan L, Childs J, Mayer L. Failure to induce oral tolerance to a soluble protein in patients with inflammatory bowel disease. Gastroenterology 2004; 126.
Kraus TA, Toy L, Chan L, Childs J, Cheifetz A, Mayer L. Failure to Induce Oral Tolerance in Crohn's and Ulcerative Colitis Patients: Possible Genetic Risk. Ann NY Acad Sci 2004; 1029.