Thomas Kraus
- ASSISTANT PROFESSOR Obstetrics, Gynecology and Reproductive Science
- ASSISTANT PROFESSOR Microbiology
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Training Areas
Biography
The maternal immune system must adapt to allow for the acceptance of the fetal tissue during implantation and throughout gestation. An inappropriate immune response to the fetus or to paternal antigens might result in infertility, failures of implantation, pre-term labor or other complications during gestation.
There is also evidence to suggest that an inappropriate maternal immune response to a virus during pregnancy can affect the fetal environment profoundly. Because of this, viral immunity during the later stages of pregnancy appears to be altered, leaving the mother more susceptible to viral infections.
With a background in mucosal immunology and virology, Dr. Kraus is studying the maternal immune response during pregnancy to the influenza vaccine. Other research interests include the general modulation in the maternal innate and adaptive immune response during the hormonal spikes that accompany different stages of gestation.
Publications
Pazos M, Kraus T, Moran T, Munoz-Fontela C. Estrogen Mediates Innate and Adaptive Immune Alterations to Influenza Infection in Pregnant Mice. PLoS ONE;.
Pazos M, Sperling R, Moran T, Kraus T. The influence of pregnancy on systemic immunity. [review]. Immunol Res 2012 March 24;.
Kraus TA, Engel SM, Sperling RS, Kellerman L, Yo Y, Wallenstein S, Escribese MM, Garrido J, Singh T, Loubeau M, Moran TM. Characterizing the pregnancy immune phenotype: Results of the Viral Immunity and Pregnancy (VIP) study. Journal of Clinical Immunology 2011;.
Sperling RS, Engel SM, Wallenstein S, Kraus TA, Garrido J, Singh T, Kellerman L, Moran TM. Immunogenicity of Trivalent Inactivated Influenza Vaccination Received During Pregnancy or Post-partum. Obstetrics & Gynecology 2011;.
Kraus TA, Sperling RS, Engel SM, Lo Y, Kellerman L, Singh T, Loubeau M, Ge Y, Garrido JL, Rodríguez-García M, Moran TM. Peripheral blood cytokine profiling during pregnancy and post-partum periods. American Journal of Reproductive Immunology (New York, N.Y. : 1989) 2010 Dec; 64(6).
Escribese MM, Kraus T, Rhee E, Fernandez-Sesma A, López CB, Moran TM, Kellerman L, Moran TM. Estrogen inhibits dendritic cell maturation to RNA viruses. Blood 2008 Dec; 112(12).
Kraus TA, Garza L, Horvath CM. Enabled interferon signaling evasion in an immune-competent transgenic mouse model of parainfluenza virus 5 infection. Virology 2008 Feb; 371(1).
Yount JS, Kraus TA, Horvath CM, Moran TM, López CB. A novel role for viral-defective interfering particles in enhancing dendritic cell maturation. Journal of immunology (Baltimore, Md. : 1950) 2006 Oct; 177(7).
Kraus Ta, Cheifetz A, Toy L, Meddings J, Mayer L. Evidence for a genetic defect in oral tolerance induction in inflammatory bowel disease. Inflamm Bowel Dis 2006; 12.
Kraus TA, Brimnes J, Muong C, Liu JH, Moran TM, Tappenden KA, Boros P, Mayer L. Mucosal Tolerance Induction in Peyer's Patch-Deficient, Ligated Small Bowel Loops. J. Clin. Invest 2005; 115.
Safadi R, Alvarez CE, Ohta M, Brimnes J, Kraus T, Mehal W, Bromberg J, Mayer L, Friedman SL. Enhanced oral tolerance in transgenic mice with hepatocyte secretion of IL-10 . J Immunol 2005; 175.
Kraus TA, Mayer L. Oral tolerance and inflammatory bowel disease. Current opinion in gastroenterology 2005 Nov; 21(6).
Kraus TA, Toy L, Chan L, Childs J, Mayer L. Failure to induce oral tolerance to a soluble protein in patients with inflammatory bowel disease. Gastroenterology 2004; 126.
Kraus TA, Toy L, Chan L, Childs J, Cheifetz A, Mayer L. Failure to Induce Oral Tolerance in Crohn's and Ulcerative Colitis Patients: Possible Genetic Risk. Ann NY Acad Sci 2004; 1029.
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Kraus did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.
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