Timothy A Blenkinsop, PhD
- ASSISTANT PROFESSOR | Cell, Developmental & Regenerative Biology
Timothy Blenkinsop's laboratory works to understand the basic biology of the adult human eye in an effort to reveal mechanisms for regeneration. We are currently focused on RPE and RPE related diseases. Our approach is to develop in vitro models of the adult human RPE layer from human donors with RPE related disease in order to more carefully study disease pathology and identify compounds that can improve disease progression. We also explore the epigenetic state of RPE in normal and pathological conditions in order to understand how the cell state is regulating gene expression. Finally, we are attempting to develop a transplantation method whereby healthy human RPE from donors can be transplanted into patients where RPE are damaged or lost to preserve or improve vision.
Multi-Disciplinary Training AreasBiophysics and Systems Pharmacology [BSP], Cancer Biology [CAB], Developmental and Stem Cell Biology [DSCB], Neuroscience [NEU]
PhD,BS, New York University,University of Wisconsin at Whitewater
Stanzel BV, Liu Z, Somboonthanakij S, Wongsawad W, Brinken R, Eter N, Corneo B, Holz FG, Temple S, Stern JH, Blenkinsop TA. Human RPE Stem Cells Grown into Polarized RPE Monolayers on a Polyester Matrix Are Maintained after Grafting into Rabbit Subretinal Space. Stem cell reports 2014 Jan; 2(1).
Rabin DM, Rabin RL, Blenkinsop TA, Temple S, Stern JH. Chronic oxidative stress upregulates Drusen-related protein expression in adult human RPE stem cell-derived RPE cells: a novel culture model for dry AMD. Aging 2013 Jan; 5(1).
Blenkinsop TA, Salero E, Stern JH, Temple S. The culture and maintenance of functional retinal pigment epithelial monolayers from adult human eye. Methods in molecular biology (Clifton, N.J.) 2013; 945.
Salero E, Blenkinsop TA, Corneo B, Harris A, Rabin D, Stern JH, Temple S. Adult human RPE can be activated into a multipotent stem cell that produces mesenchymal derivatives. Cell stem cell 2012 Jan; 10(1).
Blenkinsop TA, Corneo B, Temple S, Stern JH. Ophthalmologic stem cell transplantation therapies. Regenerative medicine 2012 Nov; 7(6 Suppl).
Lang EJ, Blenkinsop TA. Control of cerebellar nuclear cells: a direct role for complex spikes?. Cerebellum (London, England) 2011 Dec; 10(4).
Blenkinsop TA, Lang EJ. Synaptic action of the olivocerebellar system on cerebellar nuclear spike activity. The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Oct; 31(41).
Maffie J, Blenkinsop T, Rudy B. A novel DPP6 isoform (DPP6-E) can account for differences between neuronal and reconstituted A-type K(+) channels. Neuroscience letters 2009 Jan; 449(3).
Hirata Y, Katori Y, Shimokawa H, Suzuki H, Blenkinsop TA, Lang EJ, Aihara K. Testing a neural coding hypothesis using surrogate data. Journal of neuroscience methods 2008 Jul; 172(2).
Blenkinsop TA, Lang EJ. Block of inferior olive gap junctional coupling decreases Purkinje cell complex spike synchrony and rhythmicity. The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Feb; 26(6).