Research
One of the crucial challenges in biology is to understand the dynamics of molecular mechanisms in global cellular functions. We study the spatiotemporal regulatory mechanisms that exist within a signaling pathway, as these changes are essential for the progression of dynamic cellular processes such as cell division and cell death. Our recent research focuses on the regulation of the chromatin remodeling enzyme, lysine specific demethylase 1 (LSD1), as cells progress through different stages of the cell cycle. By combining cellular, molecular, genomic, and bioinformatics techniques, we found that LSD1 activity is regulated by its transient interaction with chromatin in a cell cycle-dependent manner. We aim to elucidate the mechanisms mediating the chromatin recruitment of LSD1 and its displacement from the chromatin during cell cycle progression.
Publications
Nair VD, Ge Y, Kim J, Okawa Y, Balasubramaniyan N, Chikina M, Troyanskaya OG, Sealfon SC. Involvement of histone demethylase LSD1 in short-time scale gene expression changes during embryonic stem cell cycle progression. Mol. Cell. Biol. Epub ahead of print, Oct 1, 2012;.
Nair VD, Olanow CW. Differential modulation of Akt/glycogen synthase kinase-3beta pathway regulates apoptotic and cytoprotective signaling responses. J Biol Chem 2008 May; 283(22): 15469-15478.
Nair VD, Mcnaught KS, González-Maeso J, Sealfon SC, Olanow CW. p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition. J Biol Chem 2006 Dec; 281(51): 39550-39560.
Nair VD. Activation of p53 signaling initiates apoptotic death in a cellular model of Parkinson's disease. Apoptosis 2006 Jun; 11(6): 955-966.
Verma V Et Al.. Modulation of agonist binding to human dopamine receptor subtypes by L-prolyl-L-leucyl-glycinamide and a peptidomimetic analog. J Pharmacol Exp Ther 2005 Dec; 315(3): 1228-1236.
Nair VD, Yuen T, Olanow CW, Sealfon SC. Early single cell bifurcation of pro- and antiapoptotic states during oxidative stress. J Biol Chem 2004 Jun; 279(26): 27494-27501.
Nair VD, Sealfon SC. Agonist specific transactivation of phosphoinositide 3-kinase signaling pathway medaited by the dopamine D2 receptor. J Biol Chem 2003 Nov; 278(47): 47053-47061.
Nair VD, Olanow CW, Sealfon SC. Activation of phosphoinositide 3-kinase by D2 receptor prevents apoptosis in dopaminergic cell lines. Biochem J 2003 Jul; 373(1): 25-32.
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Nair did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.
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