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William Byne

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    William Byne is a staff physician and investigator with the VISN3 MIRECC at the JJ Peters VA Medical Center, NYC, where he Directs the Laboratory of Neuroanatomy and Morphometrics.  The laboratory examines the relationship between brain structure and function in health and disease, and provides anatomical assistance to a variety of other laboratories conducting postmortem molecular biological and in vivo neuroimaging studies in serious mental illness.   Dr. Byne has recently begun to explore novel pharmacological strategies in the treatment of schizophrenia.

    After completing psychiatric residency he practiced psychiatry at the Columbia Center for Lesbian, Gay and Bisexual Mental Health and in private practice prior to establishing his laboratory at Mount Sinai in 1995.    In addition to engaging in research and clinical care he has developed curricula for medical students, residents and clinical fellows in the culturally competent delivery of healthcare to sexual minorities.  He was among the first physicians to formally serve as an advisor to the Intersex Society of North America, a role he played throughout the history of the organization.   As a member of the Consortium for Disorders of Sex Development, he contributed to Clinical Guidelines for the Management of Disorders of Sex Development in Childhood and the companion volume Handbook for Parents.

    Dr. Byne chaired the American Psychiatric Association’s (APA) Task Force on the Treatment of Gender Identity Disorder.  The Task Force Report, published in 2012, concluded that sufficient evidence exists to support production, by the APA, of clinical recommendations for psychiatrists who assess or treat children, adolescents and adults who experience Gender Dysphoria, including those with disorders of sex development.  The Report also recommended that the APA issue position statements supporting the medical necessity of treatments for Gender Dysphoria and opposing discrimination on the basis of gender variance.  These position statements have now been issued.  Dr. Byne is currently chair of an APA work group under the Committee on Research and Quality Care that is charged with implementation of the recommendations of the Task Force.  

    Dr. Byne recently co-edited, Treatment of Transgender Children and Adolescents.   This volume provides authoritative and detailed descriptions of the various treatment goals as well as approaches to the treatment of minors with Gender Dysphoria.  Among its goals is assisting parents and other primary caregivers who face the dilemma of treatment selection for minors intheir care.   Dr. Byne’s current projects include working with the Veterans Health Administration at local, regional and national levels to train VA staff in the provision of culturally competent healthcare to transgender veterans as required by VHA Directive 2011-024, Providing Health Care for Transgender and Intersex Veterans.  He is a member of the World Professional Association for Transgender Health and on the editorial boards of The Journal of Homosexuality, The Journal of Gay and Lesbian Mental Health, and editor-in-chief of LGBT Health.


Chemerinski E, Byne W, Kolaitis JC, Glanton CF, Canfield EL, Newmark RE, Haznedar MM, Novakovic V, Chu KW, Siever LJ, Hazlett EA. Larger putamen size in antipsychotic-naïve individuals with schizotypal personality disorder. Schizophrenia research 2013 Jan; 143(1).

Drescher J, Byne W, editors. Treating Transgender Children and Adolescents. London, Routledge;.

Hazlett EA, Collazo T, Zelmanova Y, Entis JJ, Chu KW, Goldstein KE, Roussos P, Haznedar MM, Koenigsberg HW, New AS, Buchsbaum MS, Hershowitz JP, Siever LJ, Byne W. Anterior limb of the internal capsule in schizotypal personality disorder: fiber-tract counting, volume, and anisotropy. Schizophrenia research 2012 Nov; 141(2-3).

Byne W, Bradley SJ, Coleman E, Eyler AE, Green R, Menvielle E, Meyer-Bahlburg HF, Pleak RR, Tompkins DA. Treatment of gender identity disorder. The American journal of psychiatry 2012 Aug; 169(8).

Byne W, Bradley SJ, Coleman E, Eyler AE, Green R, Menvielle EJ, Meyer-Bahlburg HF, Pleak RR, Tompkins DA. Report of the American Psychiatric Association Task Force on Treatment of Gender Identity Disorder. Archives of sexual behavior 2012 Aug; 41(4).

Drescher J, Byne W. Gender dysphoric/gender variant (GD/GV) children and adolescents: summarizing what we know and what we have yet to learn. Journal of homosexuality 2012; 59(3).

Drescher J, Byne W. Introduction to the special issue on . Journal of homosexuality 2012; 59(3).

Mileaf MI, Byne W. Neuronal deficit in medial pulvinar from right but not left hemisphere in schizophrenia. Schizophrenia research 2012 Feb; 134(2-3).

Mann SL, Hazlett EA, Byne W, Hof PR, Buchsbaum MS, Cohen BH, Goldstein KE, Haznedar MM, Mitsis EM, Siever LJ, Chu KW. Anterior and posterior cingulate cortex volume in healthy adults: effects of aging and gender differences. Brain research 2011 Jul; 1401.

Katsel P, Byne W, Roussos P, Tan W, Siever L, Haroutunian V. Astrocyte and glutamate markers in the superficial, deep, and white matter layers of the anterior cingulate gyrus in schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011 May; 36(6).

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Byne did not report having any of the following types of financial relationships with industry during 2015 and/or 2016: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

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Research Bldg Room 2F37, JJ Peters VA Medical Center
130 West Kingsbridge Road
Bronx, NY 10468

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