Photo of Xingxuan He

Xingxuan He

  • ASSOCIATE PROFESSOR Genetics and Genomic Sciences
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  • M.D., Hunan-Yale Medical College, Central South University

  • M.S., Hunan-Yale Medical College, Central South University

  • University of Cincinnati


    Mailing Address
    One Gustave L. Levy Place, Box 1498, New York, NY 10029

    Icahn Medical Institute, 1425 Madison Avenue, Room 1420

    Tel: (212) 659-6824


The overall goal of our research is to explore the role of sphingolipid and sphingolipid related enzyme activities in Alzheimer's disease and insulin resistance. Human samples and animal models are currently being evaluated. Our studies will help us understand the underlying mechanisms in these two common diseases and may lead to the design of the new therapeutic strategies.


He X, Huang Y, Li B, Gong CX, Schuchman EH. Deregulation of sphingolipid metabolism in Alzheimer's disease. Neurobiol. Aging 2008 Jun 9;.

Shtraizent N, Eliyahu E, Park JH, He X, Shalgi R, Schuchman EH. Autoproteolytic cleavage and activation of human acid ceramidase. J Biol Chem 2008; 283(17): 11253-11259.

Ledgerwood LG, Lal G, Zhang N, Garin A, Esses SJ, Ginhoux F, Merad M, Peche H, Lira SA, Ding Y, Yang Y, He X, Schuchman EH, Allende ML, Ochando JC, Bromberg JS. The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics. Nat Immunol 2008; 9(1): 42-53.

Simonaro CM, D'Angelo M, He X, Eliyahu E, Shtraizent N, Haskins ME, Schuchman EH. Mechanism of Glycosaminoglycan-Mediated Bone & Joint Disease: Implications for the Mucopolysaccharidoses & Other Connective Tissue Diseases. Am. J. Path 2008; 172(1): 112-122.

Eliyahu E, Park JH, Schuchman EH, He X, Shtraizent N. Acid ceramidase is a novel factor required for early embryo survival. FASEB J 2007 Jan 30;.

Darroch PI, Dagan A, Schuchman EH, He X, Gatt S, Granot T. A novel sphingomyelin analogue that inhibits sphingomyelin hydrolysis and synthesis, increases cellular ceramide, and leads to cell death. J Lipid Res 2005; 46(11): 2315-2324.

He X, Schuchman EH, Gatt S, Dagan A. Simultaneous quantitative analysis of ceramide and sphingosine in mouse blood by naphthalene-2,3-dicarboxyaldehyde derivatization after hydrolysis with ceramidase. Anal Biochem 2005; 340(1): 113-122.

He X, Schuchman EH, McGovern MM, Chen F. A Fluorescence-Based, High-Throughput Sphingomyelin Assay for the Analysis of Niemann-Pick Disease and Other Disorders of Sphingomyelin Metabolism. Anal Biochem 2002; 306(1): 115-123.

He X, Okino N, Dhami R, Schuchman EH, Gatt S, Schulze H, Sandhoff K, Dagan A. Purification and characterization of recombinant, human acid ceramidase: Catalytic reactions and interactions with acid Sphingomyelinase. J Biol Chem 2003; 278(35): 32978-32986.

He X, Chen F, Schuchman EH, Gatt S, Dagan A. A fluorescence-based, high-performance liquid chromatographic assay to determine acid sphingomyelinase activity and diagnose types A and B Niemann-Pick disease. Anal Biochem 2003; 314: 116-120.

Okino N, He X, Schuchman EH, Sandhoff K, Ito M, Gatt S. The reverse activity of acid ceramidase. J Biol Chem 2003; 278(32): 29948-29953.

Dhami R, Schuchman EH, Gordon RE, He X. Analysis of the lung pathology and alveolar macrophage function in the acid sphingomyelinase--deficient mouse model of Niemann-Pick disease. Lab Invest 2001; 81(7): 987-999.

Miranda RS, He X, Simonaro CM, Schuchman EH, Gagan A, Desnick RJ, Gatt S. Infusion of recombinant human acid sphingomyelinase into Niemann-Pick disease mice leads to visceral, but not neurological, correction of the pathophysiology. FASEB J 2000; 14: 1988-1995.

He X, Miranda SP, Schuchman EH, Mehler EL, Weinstein H, Li CM. Homologous Modeling of the Human Acid Sphingomyelinase: Structural and Functional Implications of Mutations Identified in Niemann-Pick Patients. Am. J. Hum Genet 1999; 65: A300.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. He did not report having any of the following types of financial relationships with industry during 2015 and/or 2016: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

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Icahn (East) Building Floor 14 Room 14-20
1425 Madison Avenue
New York, NY 10029

Tel: 212-659-6824