- ASSISTANT PROFESSOR Pharmacology and Systems Therapeutics
Dr. Chen is a member of the Iyengar Laboratory within the Department of Pharmacology and Systems Therapeutics.
Fingerle-Rowson G, Kaleswarapu DR, Schlander C, Kabgani N, Brocks T, Reinart N, Busch R, Schutz A, Lue H, Du X, Liu A, Xiong H, Chen Y, Nemajerova A, Hallek M, Bernhagen J, Leng L, Bucala R. A tautomerase-null macrophage migration-inhibitory factor (MIF) gene knock-in mouse model reveals that protein interactions and not enzymatic activity mediate MIF-dependent growth regulation. Mol Cell Biol 2009 Apr; 29(7): 1922-1932.
Lu TC, Wang Z, Feng X, Chuang P, Fang W, Chen Y, Neves S, Maayan A, Xiong H, Liu Y, Iyengar R, Klotman PE, He JC. Retinoic acid utilizes CREB and USF1 in a transcriptional feed-forward loop in order to stimulate MKP1 expression in human immunodeficiency virus-infected podocytes. Mol Cell Biol 2008 Sep; 28(18): 5785-5794.
He HC, Lu TC, Fleet M, Sunamoto M, Husain M, Fang W, Neves S, Chen Y, Shankland S, Iyengar R, Klotman PE. Retinoic acid inhibits HIV-1-induced podocyte proliferation through the cAMP pathway. J Am Soc Nephrol 2007 Jan; 18(1): 93-102.
Yoo B, Iyengar R, Chen Y. Functional analysis of the interface regions involved in interactions between the central cytoplasmic loop and the C-terminal tail of adenylyl cyclase. J Biol Chem 2004 Apr 2; 279(14): 13925-13933.
Santore TA, Chen Y, Smith MJ, Iyengar R. Adenovirus-directed expression of Q227L-G alpha(s) inhibits growth of established tumors of later-stage human breast cancer cells in athymic mice. Proc Natl Acad Sci USA 2002 Feb 5; 99(3): 1671-1676.
Chen Y, Yoo B, Lee JB, Weng G, Iyengar R. The signal transfer regions of G alpha(s). J Biol Chem 2001 Dec 7; 276(49): 45751-45754.
Buck E, Li J, Chen Y, Weng G, Scarlata S, Iyengar R. Resolution of a signal transfer region from a general binding domain in gbeta for stimulation of phospholipase C-beta2. Science 1999 Feb 26; 283(5406): 1332-1335.
Chen J, Bander JA, Santore TA, Chen Y, Ram PT, Smith MJ, Iyengar R. Expression of Q227L-galphas in MCF-7 human breast cancer cells inhibits tumorigenesis. Proc Natl Acad Sci USA 1998 Mar 3; 95(5): 2648-2652.
Chen Y, Harry A, Magnusson R, Iyengar R, Weng G. Differential regulation of adenylyl cyclases by Galphas. J Biol Chem 1997 Jul 25; 272(30): 19017-19021.
Chen Y, Harry A, Li J, Smith MJ, Bai X, Magnusson R, Pieroni JP, Weng G, Iyengar R. Adenylyl cyclase 6 is selectively regulated by protein kinase A phosphorylation in a region involved in Galphas stimulation. Proc Natl Acad Sci USA 1997 Dec 9; 94(25): 14100-14104.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Chen did not report having any of the following types of financial relationships with industry during 2013 and/or 2014: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.