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Yogesh Gupta

  • ASSISTANT PROFESSOR Structural and Chemical Biology
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    2012-    Assistant Professor, Structural & Chemical Biology
    2009     Instructor, Structural & Chemical Biology

    Education and Training

    2005     Postdoctoral Fellow, Physiology & Biophysics
                 Mount Sinai School of Medicine
                 (Mentor: Dr. Aneel Aggarwal)

    2005     Ph.D. in Structural Biology
                 Magnetic Resonance Center (CERM) Florence, ITALY
                 (Adviser: Prof. Claudio Luchinat, Prof. Ivano Bertini)

    2002     M.Tech. in Biotechnology
                 Anna University, Chennai, INDIA
                 (Awarded with distinction)

    2000    M.Sc. in Biochemistry
                National JALMA Institute for Leprosy
                Dr Bhimrao Ambedkar University, Agra, INDIA


    2012    Outstanding Poster Award, NYSBDG Meeting
    2008    Best Poster Award, Annual Departmental Retreat, Mount Sinai
    2004    Assegnista di ricerca, Italy
    2003    CIRMMP Fellowship, Italy
    2001    VSRP Fellow, India
    2000    DBT Fellowship, India
    1991    National Scholarship, India


Athuluri-Divakar S, Vasquez-Del Carpio R, Dutta K, Baker SJ, Cosenza SC, Basu I, Gupta YK, Reddy MV, Ueno L, Hart JR, Vogt PK, Mulholland D, Guha C, Aggarwal AK, Reddy EP. A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling. Cell 2016 Apr; 165(3): 643-655.

Callahan SJ, Luyten YA, Gupta YK, Wilson GG, Roberts RJ, Morgan RD, Aggarwal AK. Structure of Type IIL Restriction-Modification Enzyme MmeI in Complex with DNA Has Implications for Engineering New Specificities. PLoS Biology 2016 Apr; 14(4).

Gupta YK, Chan SH, Xu SY, Aggarwal AK. Structural basis of asymmetric DNA methylation and ATP-triggered long-range diffusion by EcoP15I. Nature Communications 2015 June; 6(7363).

Thompson R, Shah RB, Liu PH, Gupta YK, Ando K, Aggarwal AK, Sidi S. An Inhibitor of PIDDosome Formation. Mol Cell 2015 Jun; 58(5): 767-79.

He X, Hull V, Thomas JA, Fu X, Gidwani S, Gupta YK, Black LW, Xu SY. Expression and purification of a single-chain Type IV restriction enzyme Eco94GmrSD and determination of its substrate preference. Scientific reports 2015; 5.

Chen X, Ali Khajeh J, Ju JH, Gupta YK, Stanley CB, Do C, Heller WT, Aggarwal AK, Callaway DJ, Bu Z. Phosphatidylinositol 4,5-bisphosphate clusters the cell adhesion molecule CD44 and assembles a specific CD44-Ezrin hetero complex, as revealed by small angle neutron scattering. J Biol Chem 2015 March; 290(10): 6639-52.

Stachnik A, Yuen T, Iqbal J, Sgobba M, Gupta Y, Lu P, Colaianni G, Ji Y, Zhu LL, Kim SM, Li J, Liu P, Izadmehr S, Sangodkar J, Scherer T, Mujtaba S, Galsky M, Gomez J, Epstein S, Buettner C, Bian Z, Zallone A, Aggarwal AK, Haider S, New MI, Sun L, Narla G, Zaidi M. Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer. Proc Natl Acad Sci U S A 2014 Dec; 111(50): 17995-18000.

Yuen T, Stachnik A, Iqbal J, Sgobba M, Gupta Y, Lu P, Colaianni G, Ji Y, Zhu LL, Kim SM, Li J, Liu P, Izadmehr S, Sangodkar J, Bailey J, Latif Y, Mujtaba S, Epstein S, Davies TF, Bian Z, Zallone A, Aggarwal AK, Haider S, New MI, Sun L, Narla G, Zaidi M. Bisphosphonates inactivate human EGFRs to exert antitumor actions. Proc Natl Acad Sci U S A 2014 Dec; 111(50): 17989-94.

Mujtaba S, Winer BY, Jaganathan A, Patel J, Sgobba M, Schuch R, Gupta YK, Haider S, Wang R, Fischetti VA. Anthrax SET protein: a potential virulence determinant that epigenetically represses NF-κB activation in infected macrophages. J Biol Chem 2013 Aug; 288(32): 23458-72.

Xu SY, Gupta YK. Natural zinc ribbon HNH endonucleases and engineered zinc finger nicking endonuclease. Nucleic Acids Res 2013 Jan; 41(1): 378-90.

Gupta YK, Yang L, Chan SH, Samuelson JC, Xu SY, Aggarwal AK. Structural insights into the assembly and shape of Type III restriction-modification (R-M) EcoP15I complex by small-angle X-ray scattering. J Mol Biol 2012 Jul; 420(4-5): 261-8.

Xu SY, Nugent RL, Kasamkattil J, Fomenkov A, Gupta Y, Aggarwal A, Wang X, Li Z, Zheng Y, Morgan R. Characterization of type II and III restriction-modification systems from Bacillus cereus strains ATCC 10987 and ATCC 14579. J Bacteriol 2012 Jan; 194(1): 49-60.

Gupta YK, Lee TH, Edwards TA, Escalante CR, Kadyrova LY, Wharton RP, Aggarwal AK. Co-occupancy of two Pumilio molecules on a single hunchback NRE. RNA 2009 Jun; 15(6): 1029-35.

Gupta YK, Nair DT, Wharton RP, Aggarwal AK. Structures of human Pumilio with noncognate RNAs reveal molecular mechanisms for binding promiscuity. Structure 2008 Apr; 16(4): 549-57.

Bertini I, Gupta YK, Luchinat C, Parigi G, Peana M, Sgheri L, Yuan J. Paramagnetism-based NMR restraints provide maximum allowed probabilities for the different conformations of partially independent protein domains. J Am Chem Soc 2007 Oct; 129(42): 12786-94.

Edwards TA, Butterwick JA, Zeng L, Gupta YK, Wang X, Wharton RP, Palmer AG, Aggarwal AK. Solution structure of the Vts1 SAM domain in the presence of RNA. J Mol Biol 2006 Mar; 356(5): 1065-72.

Bertini I, Gupta YK, Luchinat C, Parigi G, Schlörb C, Schwalbe H. NMR spectroscopic detection of protein protons and longitudinal relaxation rates between 0.01 and 50 MHz. Angew Chem Int Ed Engl 2005 Apr; 44(15): 2223-5.

Baig I, Bertini I, Del Bianco C, Gupta YK, Lee YM, Luchinat C, Quattrone A. Paramagnetism-based refinement strategy for the solution structure of human alpha-parvalbumin. Biochemistry 2004 May; 43(18): 5562-73.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Gupta did not report having any of the following types of financial relationships with industry during 2015 and/or 2016: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

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