- ASSISTANT PROFESSOR Structural and Chemical Biology
Group webpage: http://www.protdnarna.org
2012- Assistant Professor, Structural & Chemical Biology
2009 Instructor, Structural & Chemical Biology
Education and Training
2005 Postdoctoral Fellow, Physiology & Biophysics
Mount Sinai School of Medicine
(Mentor: Dr. Aneel Aggarwal)
2005 Ph.D. in Structural Biology
Magnetic Resonance Center (CERM) Florence, ITALY
(Adviser: Prof. Claudio Luchinat, Prof. Ivano Bertini)
2002 M.Tech. in Biotechnology
Anna University, Chennai, INDIA
(Awarded with distinction)
2000 M.Sc. in Biochemistry
National JALMA Institute for Leprosy
Dr Bhimrao Ambedkar University, Agra, INDIA
2012 Outstanding Poster Award, NYSBDG Meeting
2008 Best Poster Award, Annual Departmental Retreat, Mount Sinai
2004 Assegnista di ricerca, Italy
2003 CIRMMP Fellowship, Italy
2001 VSRP Fellow, India
2000 DBT Fellowship, India
1991 National Scholarship, India
Gupta YK, Chan SH, Xu SY, Aggarwal AK. Structural basis of asymmetric DNA methylation and ATP-triggered long-range diffusion by EcoP15I. Nature Communications 2015 June; 6(7363).
Thompson R, Shah RB, Liu PH, Gupta YK, Ando K, Aggarwal AK, Sidi S. An Inhibitor of PIDDosome Formation. Mol Cell 2015 Jun; 58(5): 767-79.
He X, Hull V, Thomas JA, Fu X, Gidwani S, Gupta YK, Black LW, Xu SY. Expression and purification of a single-chain Type IV restriction enzyme Eco94GmrSD and determination of its substrate preference. Scientific reports 2015; 5.
Chen X, Ali Khajeh J, Ju JH, Gupta YK, Stanley CB, Do C, Heller WT, Aggarwal AK, Callaway DJ, Bu Z. Phosphatidylinositol 4,5-bisphosphate clusters the cell adhesion molecule CD44 and assembles a specific CD44-Ezrin hetero complex, as revealed by small angle neutron scattering. J Biol Chem 2015 March; 290(10): 6639-52.
Stachnik A, Yuen T, Iqbal J, Sgobba M, Gupta Y, Lu P, Colaianni G, Ji Y, Zhu LL, Kim SM, Li J, Liu P, Izadmehr S, Sangodkar J, Scherer T, Mujtaba S, Galsky M, Gomez J, Epstein S, Buettner C, Bian Z, Zallone A, Aggarwal AK, Haider S, New MI, Sun L, Narla G, Zaidi M. Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer. Proc Natl Acad Sci U S A 2014 Dec; 111(50): 17995-18000.
Yuen T, Stachnik A, Iqbal J, Sgobba M, Gupta Y, Lu P, Colaianni G, Ji Y, Zhu LL, Kim SM, Li J, Liu P, Izadmehr S, Sangodkar J, Bailey J, Latif Y, Mujtaba S, Epstein S, Davies TF, Bian Z, Zallone A, Aggarwal AK, Haider S, New MI, Sun L, Narla G, Zaidi M. Bisphosphonates inactivate human EGFRs to exert antitumor actions. Proc Natl Acad Sci U S A 2014 Dec; 111(50): 17989-94.
Mujtaba S, Winer BY, Jaganathan A, Patel J, Sgobba M, Schuch R, Gupta YK, Haider S, Wang R, Fischetti VA. Anthrax SET protein: a potential virulence determinant that epigenetically represses NF-κB activation in infected macrophages. J Biol Chem 2013 Aug; 288(32): 23458-72.
Xu SY, Gupta YK. Natural zinc ribbon HNH endonucleases and engineered zinc finger nicking endonuclease. Nucleic Acids Res 2013 Jan; 41(1): 378-90.
Gupta YK, Yang L, Chan SH, Samuelson JC, Xu SY, Aggarwal AK. Structural insights into the assembly and shape of Type III restriction-modification (R-M) EcoP15I complex by small-angle X-ray scattering. J Mol Biol 2012 Jul; 420(4-5): 261-8.
Xu SY, Nugent RL, Kasamkattil J, Fomenkov A, Gupta Y, Aggarwal A, Wang X, Li Z, Zheng Y, Morgan R. Characterization of type II and III restriction-modification systems from Bacillus cereus strains ATCC 10987 and ATCC 14579. J Bacteriol 2012 Jan; 194(1): 49-60.
Gupta YK, Lee TH, Edwards TA, Escalante CR, Kadyrova LY, Wharton RP, Aggarwal AK. Co-occupancy of two Pumilio molecules on a single hunchback NRE. RNA 2009 Jun; 15(6): 1029-35.
Gupta YK, Nair DT, Wharton RP, Aggarwal AK. Structures of human Pumilio with noncognate RNAs reveal molecular mechanisms for binding promiscuity. Structure 2008 Apr; 16(4): 549-57.
Bertini I, Gupta YK, Luchinat C, Parigi G, Peana M, Sgheri L, Yuan J. Paramagnetism-based NMR restraints provide maximum allowed probabilities for the different conformations of partially independent protein domains. J Am Chem Soc 2007 Oct; 129(42): 12786-94.
Edwards TA, Butterwick JA, Zeng L, Gupta YK, Wang X, Wharton RP, Palmer AG, Aggarwal AK. Solution structure of the Vts1 SAM domain in the presence of RNA. J Mol Biol 2006 Mar; 356(5): 1065-72.
Bertini I, Gupta YK, Luchinat C, Parigi G, Schlörb C, Schwalbe H. NMR spectroscopic detection of protein protons and longitudinal relaxation rates between 0.01 and 50 MHz. Angew Chem Int Ed Engl 2005 Apr; 44(15): 2223-5.
Baig I, Bertini I, Del Bianco C, Gupta YK, Lee YM, Luchinat C, Quattrone A. Paramagnetism-based refinement strategy for the solution structure of human alpha-parvalbumin. Biochemistry 2004 May; 43(18): 5562-73.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Gupta did not report having any of the following types of financial relationships with industry during 2014 and/or 2015: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.
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