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Yongchao Ge

  • ASSISTANT PROFESSOR Neurology
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Education

  • M.E., Peking University
    Signal and Information Processing

  • Ph.D., University of California at Berkeley
    Statistics

  • B.S., Beijing Normal University
    Probability and Statistics

Research

Research Interests

His research focuses on developments of statistical methods and tools for biological applications, especially in molecular genetics area. The emphasis is on understanding the massive data generated in functional genomics as a statistician. For example, in microarray data, he has done extensive work on finding differentially expressed genes, especially on false discovery rates and recently false discovery proportion for multiple testing problems. He is interested in many areas of microarrays: experimental design, normalization, clustering analysis and how to connect microarray data with clinical data and other biological data: sequence information, chip-seq, real time PCR, functional annotation, flow cytometry and proteomics data.

Publications

Xin Y, Ge Y, Haghighi FG. Methyl-Analyzer--whole genome DNA methylation profiling. Bioinformatics 2011 Aug; 27(16): 2296-2297.

Nudelman G, Ge Y, Hu J, Kumar M, Seto J, Duke JL, Kleinstein SH, Hayot F, Sealfon SC, Wetmur JG. Coregulation mapping based on individual phenotypic variation in response to virus infection. Immunome research 2010; 6: 2.

Ge Y, Sealfon SC, Speed TP. Multiple testing and its applications to microarrays. Statistical methods in medical research 2009 Dec; 18(6): 543-563.

Lin J, Bardina L, Shreffler WG, Andreae DA, Ge Y, Wang J, Bruni FM, Fu Z, Han Y, Sampson HA. Development of a novel peptide microarray for large-scale epitope mapping of food allergens. The Journal of allergy and clinical immunology 2009 Aug; 124(2): 315-322.

Ge Y, Sealfon SC, Speed TP. SOME STEP-DOWN PROCEDURES CONTROLLING THE FALSE DISCOVERY RATE UNDER DEPENDENCE. Statistica Sinica 2008; 18(3): 881-904.

Giordano J, Ge Y, Gelfand Y, Abrusán G, Benson G, Warburton PE. Evolutionary history of mammalian transposons determined by genome-wide defragmentation. PLoS computational biology 2007 Jul; 3(7): e137.

Ge Y, Sealfon SC, Tseng CH, Speed TP. A Holm-type procedure controlling the false discovery rate. Statistics & Probability Letters 2007; 77(12): 1756-1762.

Chu TT, Fink MY, Mong JA, John G, Auger AP, Ge Y, Sealfon SC. Effective use of microarrays in neuroendocrine research. Journal Of Neuroendocrinology 2007; 19(3): 145-161.

Gonzalez-Maeso J, Weisstaub NV, Zhou M, Chan P, Ivic L, Ang R, Lira A, Bradley-Moore M, Ge Y, Zhou Q, Sealfon SC, Gingrich JA. Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. Neuron 2007; 53(3): 439-452.

Ruf F, Hayot F, Park MJ, Lin G, Roysam B, Ge Y, Sealfon SC. Mixed Analog/Digital Gonadotrope Biosynthetic Response to Gonadotropin Releasing Hormone. Journal of Biological Chemistry 2006; 81(41): 30967-30978.

Ge Y, Li X, Sealfon SC, Speed TP. An upper confidence bound for the false discovery proportion. Proceedings of the American Statistical Association, Statistical Computing Section [CD-ROM] 2005;: 2093-2100.

Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zhang J. Bioconductor: open software development for computational biology and bioinformatics. Genome biology 2004; 5(10): R80.

Ge Y, Dudoit S, Speed TP. Resampling-based multiple testing for microarray data analysis. Test 2003; 12(1): 1-44.

Diaz E, Ge Y, Yang YH, Loh KC, Serafini TA, Okazaki Y, Hayashizaki Y, Speed TP, Ngai J, Scheiffele P. Molecular analysis of gene expression in the developing pontocerebellar projection system. Neuron 2002; 36(3): 417-434.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Ge did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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Address

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Address

Annenberg Building Floor 14 Room 70A
1468 Madison Avenue
New York, NY 10029

Tel: 212-241-3536