Photo of Zeynep Gumus

Zeynep Gumus

  • ASSISTANT PROFESSOR Genetics and Genomic Sciences
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  • B.S., Boğaziçi University

  • Ph.D., Princeton University


    Dr. Gümüş is an Assistant Professor at the Department of Genetics and Genomics and at the Icahn Institute for Genomics and Multiscale Biology at the Icahn School of Medicine at Mount Sinai. Her research focus is in computational cancer genomics. More information is at the Gumus Lab website


Chen HJ, Sun J, Huang Z, Hou H, Arcilla M, Rakhilin N, Joe DJ, Choi J, Gadamsetty P, Milsom J, Nandakumar G, Longman R, Zhou XK, Edwards R, Chen J, Chen KY, Bu P, Wang L, Xu Y, Munroe R, Abratte C, Miller AD, Gümüş ZH, Shuler M, Nishimura N, Edelmann W, Shen X, Lipkin SM. Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting. Nature biotechnology 2015 Jun; 33(6).

Bu P, Wang L, Chen KY, Rakhilin N, Sun J, Closa A, Tung KL, King S, Kristine Varanko A, Xu Y, Huan Chen J, Zessin AS, Shealy J, Cummings B, Hsu D, Lipkin SM, Moreno V, Gümüş ZH, Shen X. miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β. Nature communications 2015; 6.

Khurana E, Fu Y, Colonna V, Mu XJ, Kang HM, Lappalainen T, Sboner A, Lochovsky L, Chen J, Harmanci A, Das J, Abyzov A, Balasubramanian S, Beal K, Chakravarty D, Challis D, Chen Y, Clarke D, Clarke L, Cunningham F, Evani US, Flicek P, Fragoza R, Garrison E, Gibbs R, Gümüs ZH, Herrero J, Kitabayashi N, Kong Y, Lage K, Liluashvili V, Lipkin SM, MacArthur DG, Marth G, Muzny D, Pers TH, Ritchie GR, Rosenfeld JA, Sisu C, Wei X, Wilson M, Xue Y, Yu F, Dermitzakis ET, Yu H, Rubin MA, Tyler-Smith C, Gerstein M. Integrative annotation of variants from 1092 humans: application to cancer genomics. Science (New York, N.Y.) 2013 Oct; 342(6154).

Bu P, Chen KY, Chen JH, Wang L, Walters J, Shin YJ, Goerger JP, Sun J, Witherspoon M, Rakhilin N, Li J, Yang H, Milsom J, Lee S, Zipfel W, Jin MM, Gümüş ZH, Lipkin SM, Shen X. A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells. Cell stem cell 2013 May; 12(5).

Chen HJ, Edwards R, Tucci S, Bu P, Milsom J, Lee S, Edelmann W, Gümüs ZH, Shen X, Lipkin S. Chemokine 25-induced signaling suppresses colon cancer invasion and metastasis. The Journal of clinical investigation 2012 Sep; 122(9).

Jadid S, Sun J, Edwards R, Dizon D, Sikander S, Gümüş ZH, Lipkin SM. mir-23a regulates the transition from indolent to invasive and metastatic colon cancer. Cancer Discovery 2012;.

Freeman K, Staehle MM, Gümüş ZH, Vadigepalli R, Gonye GE, Nichols CN, Ogunnaike BA, Hoek JB, Schwaber JS. Rapid temporal changes in the expression of a set of neuromodulatory genes during alcohol withdrawal in the dorsal vagal complex: molecular evidence of homeostatic disturbance. Alcoholism, clinical and experimental research 2012 Oct; 36(10).

Suresh A, Vannan M, Kumaran D, Gümüs ZH, Sivadas P, Murugaian EE, Kekatpure V, Iyer S, Thangaraj K, Kuriakose MA. Resistance/response molecular signature for oral tongue squamous cell carcinoma. Disease markers 2012; 32(1).

Chang CW, Poteet E, Schetz JA, Gümüş ZH, Weinstein H. Towards a quantitative representation of the cell signaling mechanisms of hallucinogens: measurement and mathematical modeling of 5-HT1A and 5-HT2A receptor-mediated ERK1/2 activation. Neuropharmacology 2009; 56 Suppl 1.

Boyle JO, Gümüs ZH, Kacker A, Choksi VL, Bocker JM, Zhou XK, Yantiss RK, Hughes DB, Du B, Judson BL, Subbaramaiah K, Dannenberg AJ. Effects of cigarette smoke on the human oral mucosal transcriptome. Cancer prevention research (Philadelphia, Pa.) 2010 Mar; 3(3).

Gümüş ZH, Siso-Nadal F, Gjyrezi A, McDonagh P, Khalil I, Giannakakou P, Weinstein H. Quantification and analysis of combination drug synergy in high-throughput transcriptome studies. IEEE International Conference on Bioinformatics and Bioengineering 2010;.

Gümüş ZH, Du B, Kacker A, Boyle JO, Bocker JM, Mukherjee P, Subbaramaiah K, Dannenberg AJ, Weinstein H. Effects of tobacco smoke on gene expression and cellular pathways in a cellular model of oral leukoplakia. Cancer prevention research (Philadelphia, Pa.) 2008 Jul; 1(2).

Chang CW, Poteet E, Schetz JA, Gümüş ZH, Weinstein H. Towards a quantitative representation of the cell signaling mechanisms of hallucinogens: measurement and mathematical modeling of 5-HT1A and 5-HT2A receptor-mediated ERK1/2 activation. Neuropharmacology 2009; 56 Suppl 1.

Gümüş ZH, Floudas CA. Mixed integer nonlinear bilevel programming: deterministic global optimization. Encyclopedia of Optimization 2008; Version II.

Gümüş ZH, Sahin KH, Ciric AR. Bilevel programming: Applications in engineering. Encyclopedia of Optimization 2008; Version II.

Gümüş ZH, Floudas CA. Global Optimization of Mixed-Integer Bilevel Programming Problems. Comput. Management Science 2005; 2(3).

Gümüş ZH, Floudas CA. Deterministic Global Optimization of Mixed Integer Bilevel Programming Problems. Foundations of Computer Aided Process Design (FOCAPD) Conference Proceedings 2004;.

Gümüş ZH. Global optimization for bilevel programming problems and applications. PhD Thesis, Department of Chemical Engineering, Princeton University 2003;.

Gümüş ZH, Floudas CA. Global optimization of nonlinear bilevel programming problems. J of Global Optimization 2001;.

Floudas CA, Gümüş ZH, Ierapetritou M. Global optimization in design under uncertainty: feasibility test and flexibility index problems. Industrial and Engineering Chemistry Research 2001;.

Gümüş ZH, Floudas CA. Nonlinear bilevel programming: a deterministic global optimization framework. Computer Aided Process Engineering 2001;.

Ciric A, Gümüş ZH. MINLP: Reactive distillation column synthesis. Encyclopedia of Optimization III; 2001.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Gumus did not report having any of the following types of financial relationships with industry during 2015 and/or 2016: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

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