Current Research Studies

The following are the research studies currently underway at our Center. To get involved or to learn more about our research studies, please call 212-241-5152.

Principal Investigator: Kristen Dams-O’Connor, PhD.
This study hopes to improve our understanding of attentional deficits in people recovering from TBI. Individuals who have had a recent moderate-severe traumatic brain injury will be asked to participate in an interview about health and functioning, tests of cognition, an electroencephalography (EEG), and MRI scan at Weill Cornell Medical Center. This information will be used to develop targeted and effective interventions for helping those with TBI recover more quickly and more completely.
GCO 16-1976, IRB approval pending.

Principal Investigator: Maria Kajankova, PhD
This study uses Online EmReg, a novel, comprehensive emotion regulation skills-training intervention developed by the Brain Injury Research Center (BIRC), to address a wide range of post-TBI deficits in emotional regulation and to provide a group intervention to people with TBI who may have difficulty accessing appropriate care for their TBI-related challenges. This study will examine the efficacy of EmReg delivered via videoconference to individuals with TBI who have difficulty in emotional regulation. Participants will receive 24, 60-minute skills-training sessions twice a week for 12 weeks in an online group video-conference with 3-4 other participants. Participants will be asked to complete surveys before, during and after the intervention.
GCO 17-0988, Icahn School of Medicine at Mount Sinai IRB approved.

Principal Investigator: Kristen Dams-O’Connor, PhD
The purpose of this study is to collect information about the factors that influence clinicians' decision-making surrounding seizure prophylaxis in the context of complicated mild traumatic brain injury (TBI). Existing care guidelines provide straightforward guidance on the use of anti-epileptic drugs (AEDs) after mild TBI and after moderate-severe TBI, but the use of AEDs after complicated mild TBI is often governed by clinical judgement and expertise. This study is designed to characterize patterns of use of AEDs in mTBI, factors that influence decision-making, and to identify differences in intervention tendencies across specialties and geographic regions. Physicians across specialties that are likely to encounter patients with complicated mild TBI (e.g., neurosurgeons, neurologists, intensivist, etc.) are surveyed via electronic mailing lists of professional organizations.
GCO 18-0553, Icahn School of Medicine at Mount Sinai IRB approved

Principal Investigator: Kristen Dams-O’Connor, PhD
Individuals over the age of 18 years who have had a moderate-severe brain injury and are at least one year post-injury will have the opportunity to participate in either one or two interviews designed to learn more about brain injury and aging. Interviews will include a brief test of thinking abilities and questions about health and functioning after brain injury. Compensation is provided.
GCO# 11-1455, Icahn School of Medicine at Mount Sinai IRB approved

Principal Investigator: Kristen Dams-O'Connor, PhD. 
This study will compare the effectiveness of two established methods of managing transition from inpatient rehabilitation. The goal of this study is to determine the features of healthcare transition approaches that are most effective for improving outcomes of importance to patients after discharge from inpatient rehabilitation for TBI, as well as outcomes of importance to their families, caregivers, and healthcare providers. This project will provide critical information that will help optimize and guide the future of healthcare for survivors of TBI. 
GCO 16-1592, Icahn School of Medicine at Mount Sinai IRB approved

 

Principal Investigator: Kristen Dams-O’Connor, PhD
Individuals who have had a moderate-severe traumatic brain injury and are at least one-year post injury will be asked to participate in an interview about health and functioning, tests of cognition, a blood draw, and an MRI scan. This study is unique in that it involves brain banking. Participants will be asked, regardless of age, gender, or health condition, to consider brain donation and to make wishes known. For more information see our brain donation brochure
GCO # 13-0751, Icahn School of Medicine at Mount Sinai IRB approved

Principal Investigator: Kristen Dams-O’Connor, PhD
Research volunteers are recruited directly from our TBI Rehabilitation Unit are followed longitudinally through a series of interviews.

The Brain Injury Research Center is one of 16 TBI Model Systems Centers across the United States, each providing the highest level of comprehensive and multidisciplinary rehabilitation care that includes emergency medical, acute medical and post-acute services. In addition to providing direct services, these centers play a pivotal role in building national capacity for high-quality treatment and research serving persons with TBI, their families, and their communities.
GCO 17-0988, Icahn School of Medicine at Mount Sinai IRB approved

Principal Investigator: Kristen Dams-O'Connor, PhD. 
This study aims to evaluate the impact of TBI and military service on clinical and pathological AD/ADRD outcomes and to evaluate the associations between TBI and military service on late life cognitive, physical, and emotional health. This study uses existing data from a population-based cohort. 
GCO 16-2452, Icahn School of Medicine at Mount Sinai IRB approved

Principal Investigators: Wayne Gordon, PhD, Marcel Dijkers, PhD
This study aims to determine any possible improvements in the quality and consistency of post-TBI rehabilitation treatment.
GCO # 14-0962, Icahn School of Medicine at Mount Sinai IRB approved

Principal Investigator: Kristen Dams-O’Connor, PhD
Next of kin participate in a comprehensive interview designed to learn more about the health and functioning of their loved one in the year preceding their death. This study addresses the need to better understand TBI in adults, by characterizing factors involved in TBI’s occurrence, factors contributing to post-TBI accelerated aging and elevated medical comorbidity, and the events leading to death among survivors of TBI.
GCO # 15-0032, Icahn School of Medicine at Mount Sinai IRB approved

Principal Investigator: Kristen Dams-O’Connor, PhD
This study aims to improve the transition after discharge from a TBI rehabilitation unit by asking those who have recently been through the transition to share their experiences and offer suggestions for improvement. 
GCO # 16-0744, Icahn School of Medicine at Mount Sinai IRB approved

Support the BIRC