Recognition and Publications

Recognition

Yong Zhao, MD, PhD, American Heart Association, Marmer Research Fellow for 2010-2011

Bruce D. Gelb, MD, Election to the National Academies' Institute of Medicine (2010)

Bruce D. Gelb, MD, American Pediatric Society, Norman J. Siegel New Member Outstanding Science Award (2008)

Yong Zhao, MD, PhD, Society for Pediatric Research, Richard D. Rowe Award in Perinatal Cardiology (2006)

Inkyong Kim, BA, Associated Medical Schools of New York Annual Research Day Award (2006)

Kimihiko Oishi, MD, Eastern Society for Pediatric Research, Young Investigator Award (2005)

Chenleng Cai, PhD, Schuman Award, University of California, San Diego (2004)

Bruce D. Gelb, MD, Society for Pediatric Research, E. Mead Johnson Award (2004)

Kimihiko Oishi, MD, Society for Pediatric Research, Fellow's Basic Research Award (2004)

Publications

Gelb Research Team

Dhandapany, PS, Fabris F, Tonk R, Illaste A, Karakikes I, Sorourian M, Sheng J, Hajjar RJ, Tartaglia M, Sobie EA, Lebeche D, Gelb BD. Cyclosporine attenuates cardiomyoctye hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes. J Molec Cell Cardiol 2011, 51:4-15.

Carvajal-Vergara X, Sevilla A, D'Souza SL, Ang Y-S, Schaniel C, Lee D-F, Yang L, Kaplan AD, Adler ED, Ge Y, Cohen N, Edelmann LJ, Chang B, Waghray A, Su J, Pardo S, Lichtenbelt KD, Tartaglia M, Gelb BD, Lemischka I. Patient-specific induced pluripotent stem cell derived models of LEOPARD syndrome. Nature 2010, 465:808-812.

Pagani MR, Oishi K, Gelb BD, Zhong Y. Spacing effect: SHP-2 phosphatase regulates resting intervals between learning trials in long-term memory induction. Cell 2009, 139:186-198.

Oishi K, Zhang H, Gault WJ, Wang CJ, Tan CC, Kim I-K, Ying H, Rahman T, Pica N, Tartaglia M, Mlodzik M, Gelb BD. LEOPARD syndrome mutations in PTPN11 have gain-of-function effects during Drosophila development. Hum Molec Genet 2009, 18:193-201.

Tan CC, Sindhu KV, Li S, Nishio H, Stoller JZ, Oishi K, Puttreddy S, Lee TJ, Epstein JA, Walsh MJ, Gelb BD. Transcription factor Ap2d associates with Ash2l and ALR, a Trithorax family histone methyltransferase, to activate Hoxc8 transcription. Proc Natl Acad Sci USA 2008, 105:7472-7477.

Pandit B, Sarkozy A, Pennacchio LA, Carta C, Oishi K, Martinelli S, Pogna EA, Schackwitz W, Ustaszewska A, Landstrom A, Bos JM, Ommen SR, Esposito G, Lepri F, Faul C, Mundel P, López Siguero JP, Tenconi R, Selicorni A, Rossi C, Mazzanti L, Torrente I, Marino B, Digilio MC, Zampino G, Ackerman MJ, Dallapiccola B, Tartaglia M, Gelb BD. Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy. Nature Genet 2007, 39:1007-1012.

Tartaglia M, Pennacchio LA, Zhao C, Yadav KK, Fodale V, Sarkozy A, Pandit B, Oishi K, Martinelli S, Schackwitz W, Ustaszewska A, Martin J, Bristow J, Carta C, Lepri F, Neri C, Vasta I, Gibson K, Curry CJ, Siguero JPL, Digilio MC, Zampino G, Dallapiccola B, Bar-Sagi D, Gelb BD. Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome. Nature Genet 2007, 39:75-79.

Carta C, Pantaleoni F, Bocchinfuso G, Stella L, Vasta I, Sarkozy A, Digilio C, Palleschi A, Pizzuti A, Grammatico P, Zampino G, Dallapiccola, Gelb BD*, Tartaglia M*. Germline missense mutations affecting KRAS isoform B are associated with a severe Noonan syndrome phenotype. Am J Hum Genet 2006, 79:129-135. *Denotes co-senior authors

Gelb BD. Marfan's syndrome and related disorders- more tightly connected than we thought. N Engl J Med 2006, 355:841-844.

Oishi K, Gaengel K, Krishnamoorthy S, Kamiya K, Kim I-K, Ying H, Weber U, Perkins L, Tartaglia M, Mlodzik M, Pick L, Gelb BD. Transgenic Drosophila models of Noonan syndrome-causing PTPN11 gain-of-function mutations. Hum Molec Genet 2006, 15:543-553.

Tartaglia M, Martinelli S, Stella L, Bocchinfuso G, Flex E, Cordeddu V, Zampino G, van der Burgt I, Palleschi A, Petrucci T, Sorcini M, Schoch C, Foa R, Emanuel PD, Gelb BD. Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease. Am J Hum Genet 2006, 78:279-290.

Cai Research Team

Nie X, Sun J, Gordon RE, Cai CL, Xu PX. SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation. Develop 2010, 137:755-65.

Cai CL, Martin JC, Sun Y, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X, Stallcup WB, Denton CP, McCulloch A, Chen J, Evans SM. A myocardial lineage derives from Tbx18 epicardial cells. Nature 2008, 454:104-108.

Lin L, Cui L, Zhou W, Dufort D, Zhang X, Cai CL, Bu L, Yang L, Martin J, Kemler R, Rosenfeld MG, Chen J, Evans SM. β-Catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis, Proc Nat Acad Sci 2007, 104: 9313-9318.

Song MR, Shirasaki R, Cai CL, Ruiz EC, Evans SM, Lee SK, Pfaff SL. T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration. Develop 2006, 133:4945-55.

Park EJ, Ogden LA, Talbot A, Evans S, Cai CL, Black BL, Frank DU, Moon AM. Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling. Develop 2006, 133:2419-33.

Lin L, Bu L, Cai CL, Zhang X, Evans S. Isl1 is upstream of sonic hedgehog in a genetic cascade required for cardiac morphogenesis. Develop Biol 2006, 295:756-763.

Yang L, Cai CL, Lin L, Qyang Y, Cogen A, Chung C, Monteiro RM, Mummery CL, Fishman GI, Evans S. Isl1-Cre reveals common BMP pathway in heart and limb development. Develop 2006, 133:1575-1585.

Laugwitz KL, Moretti A, Lam J, Gruber P, Chen Y, Woodard S, Lin L, Cai CL, Lu MM, Reth M, Platoshyn O, Yuan JX, Evans S, Chien KR. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature 2005, 433:647- 653.

Cai CL, Zhou W, Yang Y, Bu L, Qyang Y, Zhang X, Rosenfeld MG, Chen J, Evans S. T-Box genes coordinate regional rates of proliferation and regional specification during cardiogenesis, Develop 2005, 132:2475-2487.

Cai CL, Liang X, Shi Y, Chu PH, Pfaff SL, Chen J, Evans S. Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Develop Cell 2003, 5: 877-889.

Zhao Research Team

Sun Y, Ge Y, Drnevich J, Zhao Y, Band M, Chen J. Mammalian target of rapamycin regulates miRNA-1 and follistatin in skeletal myogenesis. J Cell Biol 2010, 189:1157-1169.

Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ, Srivastava D. Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell 2007, 129:303-317.

Zhao Y, Srivastava D. A developmental view of microRNA function. Trends Biochem Sci 2007, 32:189-197.

Zhao Y, Samal E, Srivastava D. Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature 2005, 436:214-220.

Zhao Y, Meng XM, Wei YJ, Zhao XW, Liu DQ, Cao HQ, Liew CC, Ding JF. Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I. J Mol Med 2003, 81:297-304.

Zhao Y, Ding JF. ILK-The key kinase in the integrin signaling pathway. Foreign Med Sci – Mol Biol 2002; 23: 366-369.

Zhao Y, Wei YJ, Cao HQ, Ding JF. Molecular cloning of NELIN, a putative human cytoskeleton regulation gene. Acta Biochim Biophys Sina 2001, 33:19-24.

Cao HQ, Zhao Y, Meng XM, Ding JF. Killing effect of human pulmonary adenocarcinoma cells with TK + CD/5-Fc + GCV coexpression suicide gene systems. Acta Acad Med Sinicae 2001, 23.

Lu XD, Liu YL, Zhao Y, Liu YQ, Liew CC. Analysis of expressed sequence tags from a fetal heart cDNA library. Chinese Circ J 2000, 15: 357-359.

Zhao Y, Ding JF. Searching for differentially expressed genes. Foreign Med Sci–Genet 2000, 23: 76-80.

Wei YJ, Ding JF, Zhao Y, Wang XR, Liu YQ, Xu YY, Xiong H, Zhou Y, Hui RT, Gao RL, Qiang BQ. Construction of human adult artery and heart cDNA libraries and cloning of novel full-length cDNAs. Chinese Circ J 1999, 14: 369-371.