The Effects of Glycoxidation on Cognition
ID Number 05-0488-00002Principal Investigator(s)
Michal Schnaider Beeri
Department(s) or Division(s)
The proposed study will build on an ongoing longitudinal study (PI- Dr. Helen Vlassara- Director of the Division of Diabetes and Aging, Department of Geriatrics, at Mount Sinai School of Medicine) examining the age-dependent relationships among circulating AGE and (dietary) AGE intake, markers of oxidative stress, inflammatory markers, and vascular dysfunction in subjects over the age of 60. In the proposed study, subjects will be cognitively assessed by the Clinical Dementia Rating scale, MMSE and the extensive neuropsychological battery of the Alzheimer’s disease Research Center (ADRC) at Mount Sinai. Subjects, who might have cognitive impairment at baseline will be evaluated by the ADRC consensus diagnostic conference, based on clinical, neuropsychological, laboratory and neuroimaging studies. In the longitudinal follow up component, the same cognitive data will be collected at 18 month intervals. Subjects who decline cognitively will be evaluated by the ADRC consensus conference. We anticipate that follow up assessments will be obtained for subjects enrolled in the first six months of this study. We plan to seek additional funding to continue the follow up assessments. In addition, at baseline, we will collect DNA for APOE. APOE4 has been found to interact with several cardiovascular risk factors other than AGEs to increase the risk for cognitive decline.
(718) 584-9000 ext. 2713
Recruiting Patients: Yes