An fMRI Study of Ketamine in Treatment-Resistant Depression
ID Number 08-0874
Principal Investigator(s)James Murrough
Department(s) or Division(s)
Psychiatry
Description
The purpose of this study is to investigate the antidepressant mechanism of action of ketamine in patients with treatment-resistant major depression (TRD) using functional magnetic resonance imaging (fMRI). Ketamine is a N-methyl-D-aspartate (NMDA) glutamate receptor antagonist that has demonstrated rapid-acting antidepressant properties after a single intravenous (IV) infusion in patients with treatment-resistant major depression (TRD).The neurobiological mechanisms of the antidepressant effects of ketamine are unknown and represent a critical area of research in the pathophysiology and treatment of major depression.
Contact Information
Joanna Kim
(212) 241-6349
joanna.kim@mssm.edu
Recruiting Patients: Yes