Effects of Sevelamer Carbonate on Oxidative Stress in patients with Diabetic Nephopathy

ID Number 08-0976

Principal Investigator(s)
Helen Vlassara

Department(s) or Division(s)
Geriatrics and Palliative Medicine


The purpose of this short-term (2-months) study is to determine whether the use of sevelamer carbonate (Renvela¬©) taken together with meals can reduce the gastrointestinal absorption of Advanced Glycation End-products (AGEs) present in food, and therefore reduce inflammation and oxidative stress in patients with chronic kidney disease (CKD).  AGEs are a group of molecules formed in the body and in foods during preparation by heating. We have previously shown that ingested AGEs, markedly increase inflammation and oxidative stress. Prospective long-term studies are planned to determine if this intervention can affect disease outcomes in patients with diabetic nephropathy.

Contact Information
Renata Pyzik, Senior CRC
(212) 241-3746 or (212) 241-2567

Susan Goodman, RD
(212) 241-4834

Recruiting Patients: No