Dopamine and Motivation in Depression

ID Number 12-0116

Principal Investigator(s)
Dan V Iosifescu

Department(s) or Division(s)

Research Entity
Mood and Anxiety Disorders Program - MAP


This study seeks to investigate low reward motivation in patients with major depressive disorder (MDD) by focusing specifically on levels of dopamine in the brain. We are looking for depressed participants who have not used antidepressant medications in the past. Patients will undergo MRI and PET scans at New York State Psychiatric Institute and will receive Pramipexole (Mirapex) treatment over the course of 6 weeks at Mount Sinai. Pramipexole is marketed as a medication for Parkinson’s disease and restless legs syndrome but it has been shown to be helpful for depression in patients without Parkinson’s disease. The overall goal of this study is to examine whether Pramipexole alleviates the impairing feature of low motivation in depression. Eligible participants will receive investigational medication at no cost to them and compensation for their time.

Contact Information
Betsy Wade
(212) 241-6349

Recruiting Patients: Yes