Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE)
ID Number 15-2296Principal Investigator(s)
Department(s) or Division(s)
Endocrinology, Diabetes and Bone Disease
GRADE is a randomized clinical trial of participants diagnosed with type 2 diabetes within the past 10 years who are already on metformin. Participants will be randomly assigned to 1 of 4 commonly-used glucose-lowering drugs (glimepiride, sitagliptin, liraglutide, and basal insulin glargine), plus metformin, and will be followed for up to 7 years. The goal of the GRADE Study is to determine which combination of two diabetes medications is best for achieving good glycemic control, has the fewest side effects, and is the most beneficial for overall health in long-term treatment for people with type 2 diabetes.
Recruiting Patients: Yes