A Phase III Randomized Trial of Metformin versus Placebo on recurrence and survival in early stage Breast Cancer
ID Number 11-0926Principal Investigator(s)
Department(s) or Division(s)
Hematology and Medical Oncology
The purpose of this study is to look at whether Metformin, a drug that is commonly used to treat diabetes, can decrease or affect the ability of breast cancer cells to grow and whether Metformin will work with your other therapy to keep your cancer from recurring. (coming back)
You may qualify to take part in this study because you have had surgery to remove a breast cancer. The usual treatment for breast cancer can be either biologic therapy given by mouth or in a vein to boost the body’s natural ability to fight disease, some combination of chemotherapy (drugs given by mouth or in a vein), hormone therapy (usually a pill), both chemotherapy and hormone therapy and biologic therapy or occasionally no drug treatment. Depending on the size of the cancer you had, its appearance under the microscope and whether the cancer has spread to the lymph nodes (tissue in the arm pit), there is a chance that breast cancer may eventually return. You should discuss with your physician how likely it is that your cancer will recur.
Previous lab work has shown that Metformin may decrease the growth of different types of cancer cells, including breast cancer cells. Research has also shown that Metformin lowers the level of insulin, a hormone found in the blood that can negatively affect breast cancer.
Recruiting Patients: No