A Randomized Phase III Trial of Cisplatin and Tumor Volume Directed Irradiation Followed by Carboplatin and Paclitaxel vs. Carboplatin and Paclitaxel for Optimally Debulked, Advanced Endometrial Carcinoma (endometrium; uterus)
ID Number 05-0982-00261Principal Investigator(s)
Linus T. Chuang
Department(s) or Division(s)
Obstetrics, Gynecology, and Reproductive Science
Drugs used in chemotherapy, such as carboplatin, paclitaxel, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells. Giving chemotherapy and radiation therapy after surgery may kill any tumor cells that remain after surgery. It is not yet known whether carboplatinand paclitaxel are more effective with or without cisplatinand radiation therapy in treating patients with endometrial cancer.
This randomized phase III trial is studying carboplatinand paclitaxel to see how well they work when given with or without cisplatin and radiation therapy in treating patients with stage III or stage IVA endometrial cancer.
Recruiting Patients: Yes