Impact of Intraoperative Cell Salvage
Patients presenting for elective cesarean section will be screened for pre-procedural anemia. If the potential subject meets the selection criteria they will be presented with the option of participating in the study. Once consented the participant is randomized by enve...
Age: 18 years - 66+
Gender: Female
The Effect and Safety of a Novel CGM-Based Titration Algorithm for Basal Insulin in T2DM Participants.
The goal of this clinical trial is to compare the effect of a continuous glucose monitor
(CGM) based titration algorithm to standard titration by self-monitoring blood glucose (SMBG)
in participants with Type 2 Diabetes already using long acting insulin. The compari...
Age: 18 years - 66+
Gender: All
A Trial to Learn if Odronextamab is Safe and Well-tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Participants With Follicular Lymphoma
This study is researching an experimental drug called odronextamab, referred to as study
drug. The study is focused on participants with previously untreated follicular lymphoma (a
type of non-Hodgkin lymphoma or NHL).
This study will be made up of two parts: Pa...
Age: 18 years - 66+
Gender: All
Maternal And Infant Antipsychotic Study
The goal of this observational study is to learn about maternal psychiatric course and infant
development in pregnant individuals with severe mental illness, comparing those treated with
antipsychotics to those treated with other medications or without medication. T...
Age: 18 years - 66+
Gender: Female
A Study to Assess Luspatercept in Lower-risk Myelodysplastic Syndrome Participants
The purpose of this study is to evaluate the efficacy and safety of Luspatercept when
administered at the maximum approved dose in low-risk Myelodysplastic Syndrome participants
who require red blood cell transfusions.
Age: 18 years - 66+
Gender: All
PDE4 Inhibition in Seborrheic Dermatitis and Papulopustular Rosacea
This study is a double-blind, vehicle-controlled clinical trial. The study will take place at Icahn School of Medicine at Mount Sinai. The study will include 33-39 adult subjects with moderate-to-severe-Seborrheic dermatitis (SD) as well as 33-39 adult subjects with mod...
Age: 18 years - 66+
Gender: All
Safety, Feasibility, and Efficacy of TSCS on Stabilizing Blood Pressure for Acute Inpatients With SCI
This site-specific project will focus on a novel non-pharmacologic approach to stabilizing BP
during AIR after acute traumatic SCI. Current forms of pharmacologic and non-pharmacologic
treatments for hypotension and OH remain inadequate in the SCI population. A crit...
Age: 14 - 100 years
Gender: All
Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder for Bladder Cancer Treatment, MODERN Study
This phase II/III trial examines whether patients who have undergone surgical removal of bladder, but require an additional treatment called immunotherapy to help prevent their bladder cancer from coming back, can be identified by a blood test. Many types of tumors tend...
Age: 18 years - 66+
Gender: All
Longitudinal Cortical Demyelination in Multiple Sclerosis and Related Disorders
In this protocol, a combination of MRI, blood, and cerebrospinal fluid (CSF) analysis will be
used to understand the natural history, underlying immunologic mechanisms, and clinical
implications of central nervous system (CNS) lesions, in particular lesions in the c...
Age: 18 years - 66+
Gender: All
Targeting Drug Memories With Methylphenidate
This study aims to identify the neural, behavioral, and pharmacological mechanisms promoting
diminished expression of drug-related memories in human drug addiction. In this fMRI study
with a within-subjects placebo-controlled double-blind cross-over design, oral
m...
Age: 26 - 50 years
Gender: All
A Study of FX-909 in Patients With Advanced Solid Malignancies, Including Advanced Urothelial Carcinoma
The goal of this clinical trial is to study the safety and tolerability in all advanced solid
tumors, including advanced urothelial carcinoma.
The main question[s] it aims to answer are:
- Is FX-909 safe and tolerable
- What is the right dose level for pat...
Age: 18 years - 66+
Gender: All
Treatment With Endovascular Intervention for STroke Patients With Existing Disability
TESTED will compare the risks and benefits of endovascular thrombectomy (EVT) to medical management (no EVT) in ischemic stroke patients who have a blockage in one of the large blood vessels in the brain and have a moderate-to-severe disability prior to their stroke.
Age: 18 years - 66+
Gender: All
Ritlecitinib in CTCL
The purpose of this research study is to evaluate the effectiveness and safety of
Ritlecitinib in skin and blood in persons with Cutaneous T-Cell Lymphoma (CTCL). CTCL is a
rare type of cancer that starts in the white blood cells and eventually can result in rashes
...
Age: 18 years - 66+
Gender: All
Impact of Prophylactic Ephedrine on Fetal Heart Tracing and Uterine Tetanic Contraction After CSE
Labor analgesia is an important component of the care of laboring patients. A known side
effect of combined spinal and epidural anesthesia (a type of labor analgesia) is an increased
incidence of category II fetal heart rate tracing (defined below) and low blood pre...
Age: 18 - 55 years
Gender: Female
A Trial to Learn How the Combination of Fianlimab With Cemiplimab and Chemotherapy Works Compared With Cemiplimab and Chemotherapy for Treating Adult Patients With Advanced Non-small Cell Lung Cancer
This study is researching an investigational drug called fianlimab (also called REGN3767)
with two other medications called cemiplimab and chemotherapy, individually called a "study
drug" or collectively called "study drugs". 'Investigational' means that the study d...
Age: 18 years - 66+
Gender: All
Study to Assess Adverse Events, Change in Disease Activity, and How Oral Upadacitinib Moves Through the Body of Pediatric Participants With Moderately to Severely Active Ulcerative Colitis.
Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and
bleeding from the lining of the rectum and colon (large intestine). This study will assess
how safe and effective Upadacitinib is in treating pediatric participants with UC....
Age: 2 - 17 years
Gender: All
The Syn-Sleep Study
In collaboration with approximately 8 centers that specialize in iRBD we will recruit a total of 80 individuals for the study. All subjects will be enrolled into a 2-year longitudinal study where skin biopsies will be performed at 3 sites on each patient at 12-month int...
Age: 18 - 85 years
Gender: All
The Ambient Light Multiple Myeloma Study
The aim of this multi-site randomized control trial will be is to assess the impact Systematic lighting on circadian rhythm entrainment, Inflammation, Neutropenic Fever and Symptom Burden among Multiple Myeloma Patients undergoing Autologous Stem Cell Transplantation. T...
Age: 21 years - 66+
Gender: All
Study of Obeldesivir in Nonhospitalized Participants With COVID-19
The goal of this clinical study is to test if obeldesivir (formerly GS-5245) is safe and
effective for the treatment of coronavirus disease 2019 (COVID-19) in participants who have a
standard risk of developing severe illness. This study will also measure how much o...
Age: 12 - 64 years
Gender: All
A Study to Test Asundexian for Preventing a Stroke Caused by a Clot in Participants After an Acute Ischemic Stroke or After a High-risk Transient Ischemic Attack, a So-called Mini Stroke
Researchers are looking for a better way to prevent an ischemic stroke which occurs when a
blood clot travelled to the brain in people who within the last 72 hours had:
- an acute stroke due to a blood clot that formed outside the heart (acute
non-cardioembolic ...
Age: 18 years - 66+
Gender: All