The Effect and Safety of a Novel CGM-Based Titration Algorithm for Basal Insulin in T2DM Participants.
The goal of this clinical trial is to compare the effect of a continuous glucose monitor
(CGM) based titration algorithm to standard titration by self-monitoring blood glucose (SMBG)
in participants with Type 2 Diabetes already using long acting insulin. The compari...
Age: 18 years - 66+
Gender: All
Cholesterol Lowering and Residual Risk in Diabetes, Type 1
This is a prospective, interventional, cohort study, meaning that researchers will follow and observe a group of enrolled study participants over a period of time (one to two months) to gather information and record any developments of the outcomes in question. This stu...
Age: 18 - 89 years
Gender: All
Sotagliflozin in Heart Failure With Preserved Ejection Fraction (HFpEF) Patients
The clinical benefits of the dual Sodium-Glucose cotransporter (SGLT) 1 and 2-inhibition have
recently been reported in two clinical trials. The SOLOIST reported the benefits of
sotagliflozin in Type-2 Diabetes Mellitus (T2DM) patients hospitalized for worsening of ...
Age: 18 years - 66+
Gender: All
Adipose Tissue Depots and Metabolism
Researchers at the Diabetes, Obesity and Metabolism Institute are seeking healthy volunteers between 18 and 65 years of age for a study on Fat and Health. The study requires up to three visits to the clinical research unit at Mount Sinai Morningside. Participants will d...
Age: 18 - 65 years
Gender: All
Healthy Mediation Adherence To Transform and Effectively Relieve Symptoms
The goal of the parent R01 study has been to determine how beliefs about chronic illness and their treatments affect SMB in the context of chronic obstructive pulmonary disease (COPD) with comorbid hypertension (HTN) and or diabetes (DM). The educational counseling modu...
Age: Birth - 66+
Gender: All
Electrical Vestibular Nerve Stimulation (VeNS) Compared to Sham Control as a Means of Improving Glycemic Control in Adults With Type 2 Diabetes Mellitus
Trial Title A randomized, double blind sham controlled clinical trial to evaluate the
efficacy of vestibular nerve stimulation (VeNS), together with a lifestyle modification
program, compared to a sham control with a lifestyle modification program, as a means of
i...
Age: 22 - 70 years
Gender: All
Prediabetes and Type 2 Diabetes Data Collection Study
To collect data in an observational study from Prediabetes (PD) and Type 2 Diabetes (T2D)
patients including time correlated CGM, medication and food intake approximately 80% of the
time for each subject that completes the entire active phase.
Age: 18 years - 66+
Gender: All
Evaluation of the Efficacy and Safety of Duodenal Mucosal Resurfacing Using the Revita® System in Subjects With Type 2 Diabetes on Insulin Therapy
The Revita® system is being investigated to assess the efficacy of DMR versus Sham on improvement in Glycemic, Hepatic and Cardiovascular endpoints for patients with Type 2 Diabetes who are inadequately controlled with insulin therapy. The purpose of this study is t...
Age: 21 - 70 years
Gender: All
Evaluation of the Efficacy and Safety of Duodenal Mucosal Resurfacing Using the Revita® System in Subjects With Type 2 Diabetes on Insulin Therapy
The Revita® system is being investigated to assess the efficacy of DMR versus Sham on
improvement in Glycemic, Hepatic and Cardiovascular endpoints for patients with Type 2
Diabetes who are inadequately controlled with insulin therapy. The purpose of this study is
...
Age: 21 - 70 years
Gender: All
Cellular Mechanisms Regulating Depot Differences in Subcutaneous Adipose Tissue in Women
Researchers at the Diabetes, Obesity and Metabolism Institute are seeking healthy volunteers between 18 and 40 years of age with apple- or pear- shaped body for a study on fat and health in women (please request for body shape image email). The study requires up to thre...
Age: 18 - 40 years
Gender: Female
Light and the Effect on Metabolic Syndrome and Alzheimer's Disease
This study's main hypothesis is that a delivering a tailored lighting intervention (TLI) will
provide a successful means for promoting circadian entrainment and treating metabolic disease
and inflammation in patients with mild cognitive impairment (MCI) and Alzheime...
Age: 55 years - 66+
Gender: All
Longitudinal Observation of Insulin Requirements and Sensor Use in Pregnancy
The overall goal of this study is to enroll pregnant women with type 1 diabetes and follow their glycemic outcomes prospectively throughout pregnancy and into the post-partum period. The investigators anticipate that when compared to subjects using an Artificial pancrea...
Age: 18 - 40 years
Gender: Female
EMPEROR-HF: A phase III randomised, double-blind trial to evaluate efficacy and safety of once daily empagliflozin 10 mg compared to placebo, in patients with chronic Heart Failure with reduced Ejection Fraction (HFrEF)
Chronic heart failure (HF) is a progressive syndrome characterized by the inability of the heart to provide adequate blood supply to meet the metabolic demand of different tissues or to be able to do so only at the expense of elevated left ventricle filling pressure. HF...
Age: 18 - 45 years
Gender: All
An Exploratory, Randomized, Double-blind, Placebo-controlled, Parallel Arm Trial of the Safety and Pharmacodynamic Activity of Sotagliflozin in Hemodynamically Stable Patients with Worsening Heart Failure
Sotagliflozin (Sanofi code SAR439954, Lexicon code LX4211) is an orally administered small molecule, the first dual inhibitor of sodium-glucose co-transporter 1 and 2 (SGLT1 and SGLT2), formulated as 75 mg and 200 mg coated tablets. The compound, a member of the pharmac...
Age: 18 - 85 years
Gender: All
P-15L Bone Graft in Transforaminal Lumbar Interbody Fusion With Instrumentation
The aim of this trial is to evaluate if P-15L bone graft (investigational device) is not inferior in effectiveness and safety to local autologous bone (and allograft where necessary) as an extender (control device) when applied in instrumented transforaminal lumbar inte...
Age: 22 - 80 years
Gender: All
A Trial Comparing Insulin Degludec and Glargine U100 for Management of Hospitalized and Discharged Patients With Type 2 Diabetes
The purpose of this study is to find out if treatment with Degludec insulin when compared to
glargine U100 insulin will result in similar blood sugar control in patients with diabetes,
who are admitted to the hospital and then transition at home, after discharge from ...
Age: 18 years - 66+
Gender: All
Hyperbaric Oxygen Therapy for Cognition in Diabetic Elderly at High Dementia Risk
An urgent need exists to identify effective interventions to arrest or reverse dementia and
cognitive loss at its earliest stages. The proposed pilot randomized clinical trial will
investigate the short and long-term effects of hyperbaric oxygen therapy on cognitive...
Age: 65 years - 66+
Gender: All
PriMatrix for the Management of Diabetic Foot Ulcers
The study will evaluate the efficacy of PriMatrix Dermal Repair Scaffold in the management of diabetic foot ulcers in subjects with diabetes mellitus versus the Standard of Care treatment. Half of patients will be treated using PriMatrix while the other half will receiv...
Age: 18 years - 66+
Gender: All
Transformative Research in Diabetic Nephropathy
This is a prospective, observational, cohort study of patients with a clinical diagnosis of
diabetes who are undergoing clinically indicated kidney biopsy. The intent is to collect,
process, and study kidney tissue and to harvest blood, urine and genetic materials t...
Age: 18 - 100 years
Gender: All
Study of Procoagulation Markers in Stroke Patients
The Insights on Selected Procoagulation Markers and Outcomes in Stroke Trial (I-SPOT): Response to Insulin Administration and Blood Glucose Control proposal is designed to accompany the Stroke Hyperglycemia Insulin Network Effort (SHINE) clinical trial, a Phase III mult...
Age: 18 years - 66+
Gender: All