Safety and Effectiveness of Corneal Crosslinking (CXL): Keratoconus and Post-Refractive Ectasia
ID Number 16-0627Principal Investigator(s)
Penny A Asbell
Department(s) or Division(s)
This prospective, randomized study is being conducted to evaluate the safety and effectiveness of corneal cross-linking (CXL) in patients with keratoconus or post-refractive ectasia (post-LASIK or PRK). Crosslinking involves saturating the cornea with riboflavin drops (vitamin B2) and exposing the cornea to ultraviolet (UV) light. The UV light allows the riboflavin to "crosslink" with the cornea, ultimately strengthening it. This study will compare two CXL techniques: one in which the corneal epithelium is removed before riboflavin drops are added ("standard" Epi-Off technique) or one in which the corneal epithelium is maintained and riboflavin is infused into the cornea using a small electric current (Epi-On technique with iontophoresis; I-CXL. Patients will be randomized to receive CXL treatment with either the Epi-On or Epi-Off technique.
Recruiting Patients: Yes