The Genetics of Endophenotypes and Schizophrenia
ID Number 01-0550Principal Investigator(s)
Larry J Siever
Department(s) or Division(s)
The purpose of this research is to learn more about the genetic transmission of schizophrenia by attempting to identify how specific sub-clinical phenomena associated with the disorder, commonly referred to as the endophenotype, may run in families of a schizophrenic proband. A number of different studies have shown various neurophysiological and neurocognitive deficits to be associated with schizophrenia. Neurophysiological deficits include abnormal even related potentials, inhibited startle response and eye movements. Neurocognitive deficits include poor performance on both verbal and working memory. These same deficits are seen in unaffected relatives of schizophrenics, which indicates that they might reflect part of the heritable risk for the illness. This conclusion is reinforced by findings of the deficits in non-psychotic, unmedicated schizophrenics and schizotypals.
Recruiting Patients: Yes