Advanced Glycation End Products (AGEs) and Alzheimer’s Disease
ID Number 03-0568Principal Investigator(s)
Michal Schnaider Beeri
Department(s) or Division(s)
The focus of this study is the identification of non-genetic and genetic risk factors associated with very late onset Alzheimer’s Disease (AD). Factors of particular interest include many of the factors that are already associated with cardiovascular disease including cholesterol, consumption of saturated fat, and physical activity levels. Other factors include the gene for apolipoprotien E and family history of dementia. We will be investigating these factors in a population of elderly non-demented individuals. We are interested in this group mainly because these individuals face a very high risk for AD which commonly emerges in very old age, and this population is a poorly studied group with respect to AD. Previous work from our group and others have indicated that genetic factors have a reduced role in explaining the emergence of AD at very late ages at onset. The subjects in this study are followed to assess any cognitive changes in their cognitive status and any other life factors. We hypothesize many of the same factors associated with cardiovascular disease will be similarly associated with the risk of AD. Hence, increased LDL cholesterol may increase the risk of AD, and increased HDL cholesterol may decrease the risk of AD.
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Recruiting Patients: Yes