ID Number 13-0147Principal Investigator(s)
Ethylin W Jabs
Department(s) or Division(s)
Genetics and Genomic Sciences
Craniosynostosis is a common birth defect that requires surgical treatment during the first year of life to prevent severe neurologic deficits. An international team of investigators will generate large genomic and expression datasets on mouse models and humans with craniosynostosis by using state-of-the-art imaging, genetic, and developmental & systems biology approaches to quantitatively model novel pathways and networks involved in embryonic and postnatal development of craniosynostosis. Quantitative and functional validations of these predictions will provide insights into the etiology and potential therapeutic targets for craniosynostosis and many bone-related disorders.
Recruiting Patients: Yes