The Friedman Brain Institute

Schizophrenia and Bipolar Disorder

Psychotic disorders, like schizophrenia and bipolar disorder, disturb particularly human aspects of perception and cognition.  The overall burden of suffering for patients, their families, and society is huge.

These disorders have proven resistant to the best neurobiological and genetic experimental strategies – and many of the key issues that could lead to improved diagnosis and treatment are still not understood. But there is now growing cause for optimism. In the last decade, we have moved from knowing nothing about the types and number of genetic loci involved in these diseases to having a substantial understanding of their genetic risk factors.  At Mount Sinai, we have assembled a diverse team of both basic and clinical researchers to translate these research findings into clinical care.

Areas of Research

Our research in schizophrenia and bipolar disorder is focused on a number of different areas.

Genetics and Genomics of Schizophrenia and Bipolar Disorder 

Both schizophrenia and bipolar disorder are strongly familial, but until recently they have proven resistant to genetic methodologies for identifying their etiology. The emergence of strong and convincing genetic evidence indicates a contribution of many DNA changes to the risk of becoming ill, along with increasing evidence for epigenetic mechanisms at work. We are deeply involved in large-scale genomic and epigenomic studies of these diseases that we expect will lead to important new insights into their causes.

Scientists involved: Schahram Akbarian,  Katherine BurdickJoseph BuxbaumJoel DudleyGang FangMenachem FromerShaun PurcellPanos RoussosEric SchadtJeremy SilvermanPamela SklarEli Stahl

Coming to a Biological Understanding of Schizophrenia and Bipolar Disorder

Schizophrenia and bipolar disorder are diseases of abnormal development and functioning of synaptic circuitry.  Our researchers are developing state-of-the-art neural stem cell models, as well as pursuing more traditional approaches, including neuroimaging.

Scientists involved: Kristen BrennandJoseph BuxbaumKenneth DavisStella (Plevan) DrachevaSophia FrangouJoseph FriedmanFatemeh (Victoria) Haghighi, Harry HaroutunianJavier Gonzalez-MaesoHirofumi Morishita

New Treatments for Schizophrenia and BipolarDisorder  

Our work is focused on translating basic findings from genetics into actionable treatment trials.  We have established a Psychosis Research Program devoted to applying the best new practices emerging from basic and translational studies to patient care.  Our scope is broad and includes studies and researchers at the James J. Peterson Veterans Affairs Medical Center in the Bronx and the Mount Sinai Health System.

Scientists involved:  Katherine BurdickWilliam Byne, Lisa Dixon, Sophia Frangou, Fiona GraffErin HazlettDan Iosifescu, Harold Levine, Margaret McClureLarry Siever

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