Funded Research

You can read about our current research below.

Microenvironments and Signaling Pathways Regulating Early Dissemination, Dormancy and Metastasis

Principal Investigator: Julio Aguirre-Ghiso, PhD
Sponsor: CDMRP
Purpose: Study the role of tumor microenvironments of metastasis in primary and secondary sites of growth and the regulation of early disseminated tumor cell fate in cancer.
Term: 2014-present

Organ Specific Macrophages and the Regulation of Disseminated Tumor Cell Fate

Principal Investigator: Julio Aguirre-Ghiso, PhD
Sponsor: NCI/NIH
Purpose: Study the different functions of bone marrow and lung macrophages in dictating disseminated tumor cell fate and the molecular cues that distinguish these two microenvironments.
Term: 2014-present

Development of Novel Anti-dormancy Therapies

Principal Investigator: Julio Aguirre-Ghiso, PhD
Sponsor: Eli Lilly
Purpose: To identify, validate, and pharmacologically target novel surface proteins, as well as surface or intracellular kinases that might affect dormant tumor cell survival, quiescence, or outgrowth after dormancy.
Term: 2012-present

Tumor Microenvironments Determining Migration, Dissemination and Dormancy

Principal Investigator: Julio Aguirre-Ghiso, PhD
Sponsor: NIH/NCI 
Purpose: Study the microenvironments in primary tumors that drive tumor cell dissemination and survival, and dormancy and growth at secondary organs.                                      
Term: 2011-present

Regulation of Disseminated Tumor Cell Fate by RARb and NR2F1 Signaling

Principal Investigator: Julio Aguirre-Ghiso, PhD
Sponsor: Samuel Waxman Cancer Research Foundation
Purpose: Study the role of RARb and NR2F1 to the dormancy of disseminated tumor cells to the bone marrow and lung in HNSCC and breast cancer models.
Term: 2009-present

Functional Determinants of Metastatic Dormancy

Principal Investigator: Julio Aguirre-Ghiso, PhD
Sponsor: NCI/NIH
Purpose: Study the role of p53, BHLHB3, and ATF6 signaling pathways in the induction of dormancy and survival of dormant disseminated tumor cells in the bone marrow. Isolate and functionally characterize bone marrow disseminated tumor cells in different target organs.
Term: 2004-present

Phase II Trial of ADXS11-001 Vaccine for HPV-related Oropharyngeal Cancer

Principal Investigator: Brett Miles, MD, DDS
Sponsor: Advaxis, Inc.
Purpose: Evaluate the efficacy of a vaccine in patients who already have an HPV-associated oropharyngeal cancer, but have not undergone chemotherapy or radiation.
Term: 2015-present

The Role of Doxycycline in Severe Chronic Rhinosinusitis with Nasal Polyps

Principal Investigator: Benjamin Malkin, MD, and Arjun Parasher, MD
Sponsor: CORE Program Grant Partners (includes the AAO and AAOA)
Purpose: Evaluate the efficacy of the combination regimen, doxycycline and oral steroids, versus just oral steroids, among patients with CRSwNP.
Term: 2015-present


Principal Investigator: Brett Miles, MD, DDS
Sponsor: John’s Hopkins University
Purpose: Test hypothesis that HRME will provide a reliable, accurate imaging platform that when coupled with targeted contrast agents (specifically fluorescent labeled EGFR contrast dyes), will allow surgeons to differentiate normal from malignant mucosal cells.
Term: 2016-2017

Exploring the Association between Immune-Related Genetic Variation and HNSCC

Principal Investigator: Chaya Levovitz, BA
Sponsor: NCI/NIH
Purpose: Explore the association between genetic variations in IRGs and susceptibility to HNSCC and identify candidate IRGs associated with increased risk of HNSCC.
Term: 2015-2016

Resolve II Study 

Principal Investigator: Alfred Iloreta, MD
Sponsor: Entersect, ENT
Purpose: Clinical evaluation of safety and efficacy of steroid-releasing S8 sinus implant in chronic sinusitis patients with recurrent sinus obstruction.

Role of Honey for Local Wound Care of Donor Sites after Split Thickness Skin Grafting

Principal Investigator: Joshua Rosenberg, MD
Sponsor: Derma Sciences
Purpose: Compare post-operative wound healing recovery time between standard local wound care (occlusive petroleum ointment dressings) and honey impregnated gauze.
Term: 2015-present

Learn more about our past funded projects