MedPage Today – Novel Drug Helps Brains Beginning to Falter – Ed Susman
An investigative agent that attempts to modulate microglia cells in the brain appears to improve memory among patients diagnosed with mild cognitive impairment, an interim analysis of a phase II study sponsored by Chiesi Farmaceutici in Italy showed. Mary Sano, PhD, of the Icahn School of Medicine at Mount Sinai, said, "This group of patients with mild cognitive impairment is a cohort we have been thinking about for quite a while. This agent with a novel mechanism of action targets microglia cells in looking at inflammatory markers. This is an approach that we have heard a lot of talk about in basic science of Alzheimer's disease and now here is an intervention that is going in that direction."
-Dr. Mary Sano, Associate Dean for Clinical Research, Professor, Psychiatry, Icahn School of Medicine at Mount Sinai