Medscape - Potential Cause of Depression Identified

 – February 20, 2013  –– 

A protein involved in synaptic structure has been identified as a potential cause of depression, a finding that according to researchers has "enormous therapeutic potential for the development of biomarkers and novel therapeutic agents." Investigators at the Icahn School of Medicine at Mount Sinai found decreased expression of Rac1 in the postmortem brains of people with major depressive disorder (MDD) and in mice subjected to chronic stress. "Our study is among only a few in depression research in which two independent human cohorts and animal models validate each other,” said study investigator Scott Russo, PhD. The study was published online Feb. 17 in Nature Medicine.
- Dr. Scott Russo, Assistant Professor, Neuroscience, Icahn School of Medicine at Mount Sinai 
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