Simons Foundation: Autism Research Initiative - Brain Activity of MicroRNAs Gives Clues about Autism - Laura Geggel
Small regulatory RNA molecules are most active between infancy and early childhood in a region of the brain known for complex thinking and behavior, reports a new study published in Molecular Psychiatry. The finding, based on an analysis of postmortem brains, may provide insight into what goes wrong in neurodevelopmental disorders such as autism. "I am amazed at how few molecules change their expression within each brain region," said Schahram Akbarian, MD, a Professor of Psychiatry and Neuroscience at the Icahn School of Medicine at Mount Sinai who was not involved in the study. "It looks like many of the psychological and cognitive changes during normal human development cannot be fully captured in molecular assays from postmortem brains."
-Dr. Schahram Akbarian, Professor, Psychiatry, Neuroscience, Icahn School of Medicine at Mount Sinai