Recognition and Publications

Recent Publications

  1. Salama G, Akar FG (2011). Deciphering Arrhythmia Mechanisms - Tools of the Trade. Card Electrophysiol Clin. 2011 Mar; 3(1):11-21.
  2. Xie C, Akar FG (2010). Mitochondrial dysfunction: a new frontier in the search for elusive arrhythmia mechanisms. Front Physiol. 2010. Dec 17; 1:163
  3. Akar FG, Clancy CE (2010). Arrhythmia models: in vivo, in vitro, and in silico. Drug Discov Today Dis Models. 6(3):55-56. PMID: 21072326
  4. Hajjar RJ, Akar FG (2010). Regression of cardiac hypertrophy by cyclic guanosime monophosphate-dependent protein kinase signaling: are myocytes active sources or mere beneficiaries? J Am Coll Cardiol. 2010 Oct 13 [Epub ahead of print] PMID: 20970281
  5. Biary N, Akar FG (2010). A brighter side of ROS revealed by selective activation of {beta}-adrenergic receptor subtypes. J Physiol. 2010 Aug 15;588(Pt 16):2973-4.
  6. Lyon AR, Joudrey PJ, Jin D, Nass RD, Aon MA, O’Rourke B, Akar FG (2010). Optical imaging of mitochondrial function uncovers actively propagating waves of mitochondrial membrane potential collapse across intact heart. J Mol Cell Cardiol 2010 Jul 16. [Epub ahead of print] PMID: 20624394
  7. Jin H, Nass RD, Joudrey PJ, Lyon AR, Chemaly ER, Rapti K, Akar FG (2010). Altered spatio-temporal dynamics of the mitochondrial membrane potential in the hypertrophied heart. Biophys J 2010 May 19; 98(10):2063-71.
  8. Akar FG (2010). Left ventricular repolarization heterogeneity as an arrhythmic substrate in heart failure. Miverva Cardioangiol. 2010 Apr; 58(2):205-12.
  9. Akar FG (2010). Use-dependent modulation of myocardial conduction by a new class of HERG agonists: Deal breaker or cherry-on-top? J Cardiovasc Electrophysiol In Press (March 2010). [Epub ahead of print] PMID: 20367661
  10. Hesketh GG, Shah MH, Halperin Vl, Cooke CA, Akar FG, Kass DA, Tomaselli GF (2010). Ultrastructure and regulation of lateralized Connexin43 in the failing heart. Circ Res 2010 Apr 2; 106(6): 1153-63.
  11. Jin H, Chemaly ER, Lee A, Kho C, Hadri L, Hajjar RJ, Akar FG (2010). Mechano-electrical remodeling and arrhythmias during progression of hypertrophy. Faseb J. 2010 Feb; 24(2):451-63. Epub 2009 Oct 13.
  12. Aiba T, Hesketh GG, Liu T, Carlisle R, Villa-Abrille Mc, O’Rourke B, Akar FG, Tomaselli GF (2010). Na+ Channel regulation by Ca2+/calmodulin and Ca2+/Calmodulin protein kinase II in guinea-pig ventricular myocytes. Cardiovasc Res. 2010 Feb 1; 85(3):454-63.
  13. Aon MA, Cortassa S, Akar FG, Brown DA, Zhou L, O’Rourke B (2009). From Mitochondrial dynamics to arrhythmias. Int J Biochem Cell Biol 2009; 41(10):1940-8.
  14. Aiba T, Hesketh GG, Barth AS, Liu T, Daya S, Dimaano VL, Abraham TP, O’Rourke B, Akar FG, Kass DA, Tomaselli GF (2009). Electrophysiological Consequences of Dyssynchronous Heart Failure and Its Restoration by Resynchronization Therapy. Circulation 2009 Mar 10; 119(9): 1220-30.

Awards

 

Circulation Research; Volume 106, Number 6, April 2, 2010
The International Journal of Biochemistry and Cell Biology, Volume 41, Issue 10, October 2009
Circulation Research; Volume 95, Number 7, October 1, 2004
  • Author of manuscript selected among “Groundbreaking Studies in the Practice of Cardiovascular Medicine: Circulation Editor’s Choice, 2006-2007”. Bioartificial Sinus Node Constructed via in Vivo Gene Transfer of an Engineered Pacemaker HCN Channel Reduces the Dependence on Electronic Pacemaker in a Sick-Sinus Syndrome Model.
  • Journal Cover: Trends in Cardiovascular Medicine; Volume 15, Issue 7, October 2005.
  • 1st co-author of the 2005 Best Paper Award for Circulation. Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers. Chicago IL, November 2006.
  • Winner of the 2005 Melvin L. Marcus Award of the American Heart Association, Dallas TX, November 2005.
  • Mentor to Dr. L Razzouk, recipient of the 2008 New York Academy of Medicine Glorney Raisbeck Fellowship in Cardiovascular Sciences.
  • Mentor to Samuel Hahn, Recipient of the provost research award, Johns Hopkins University. Baltimore MD, April 2004.
  • Young Investigator Award, 2nd prize. American Federation of Medical Research. Chicago IL September 1998.

Activities

04/06 - Invited talk, International Society of Computerized Electro Cardiology, Niagara, Ontario, "Optical Imaging of Arrhythmias in Heart Failure"

05/06 - Invited talk, Heart Rhythm Society, Boston, MA, "Electrophysiological Remodeling in the Structurally Diseased Heart, New Insights"

04/07 - Invited talk, International Society of Computerized Electrocardiology, Cancun, Mexico, "Energetic Regulation of Ion Channels and Arrhythmias"

05/07 - Session Chair, Heart Rhythm Society, Denver, CO, "Expression of Ion Channels, On the Way to Remodeling, Denver, CO"

Peer Review

Active reviewer: Circulation, Circulation Research, American Journal of Physiology, Journal of Cardiovascular Electrophysiology, Pacing and Clinical Electrophysiology, Molecular Therapy, and Hypertension.