Recognition and Publications
Baron MH, Evans DR, Lipscomb WN. The Location and Local Environment of the Active Sites of Aspartate Transcarbamylase of Escherichia coli. J. Biol. Chem. 1979; 254: 10686-10693.
Das Gupta A, Baron MH, Baltimore D. Poliovirus replicase: A soluble enzyme able to initiate copying of poliovirus RNA. Proc. Natl. Acad. Sci. USA. 1979; 76: 2679-2683.
Baron MH, Baltimore D. Antibodies Against the Chemically Synthesized Genome-Linked Protein of Poliovirus React with Native Virus-Specific Proteins. Cell. 1982; 28: 395-404.
Baron MH, Baltimore D. Purification and Properties of a Host Cell Protein Required for Poliovirus Replication in Vitro. J.Biol. Chem. 1982; 257: 12351-12358.
Baron MH, Baltimore D. In Vitro Copying of Viral Positive Strand RNA by Poliovirus Replicase: Characterization of the Reaction and its Products. J. Biol. Chem. 1982; 257: 12359-12366.
Baron MH, Baltimore D. Antibodies Against a Synthetic Peptide of Poliovirus Replicase Protein: Reaction with Native, Virus-Encoded Proteins and Inhibition of Virus-Specific Polymerase Activities in Vitro J. Virol. 1982; 43: 969-978.
Baron MH, Baltimore D. Anti-VPg Antibody Inhibition of the Poliovirus Replicase Reaction and Production of Covalent Complexes of VPg-Related Polypeptides and Newly-Made RNA. Cell. 1982; 30: 745-752.
Baron MH, Maniatis T. Rapid Reprogramming of Globin Gene Expression in Transient Heterokaryons. Cell. 1986; 46: 591-602.
Baron MH, Maniatis T. Stage-Specific Reprogramming of Globin Gene Expression. Progr. Clin. Biol. Res. 1987; 271-284.
Baron MH, Maniatis T. Reprogramming of Globin Gene Expression in Interspecific Heterokaryons. In Molecular Approaches to Developmental Biology, Alan R. Liss, Inc., 1987; pp. 469-476.
Baron MH, Maniatis T. Regulated Expression of Human α and β Globin Genes in Transient Heterokaryons. Mol. Cell. Biol. 1991; 11: 1239-1247.
Trepicchio WL, Dyer MA, Baron MH. Developmental regulation of the human embryonic β-like globin gene is mediated by synergistic interactions among multiple tissue- and stage-specific elements, Mol. Cell. Biol. 1993; 13 : 7457-7468.
Baron MH. Reversibility of the Differentiated State in Somatic Cells. Current Opinion Cell Biol. 5: 1050-1056, Current Biology Ltd. 1993; London.
Baron MH, Farrington SM. Positive regulators of the lineage-specific transcription factor GATA-1 in differentiating erythroid cells, Mol. Cell. Biol. 1994; 14: 3108-3114.
Trepicchio WL, Dyer MA, Baron MH. A novel developmental regulatory motif required for stage-specific activation of the ε-globin gene and nuclear factor binding in embryonic erythroid cells, Mol. Cell. Biol. 1994; 14: 3763-3771.
Trepicchio WL, Dyer MA, Hardison RC, Baron MH. Upstream regulatory region of the human embryonic β-like globin gene, ε, DNA Sequence. 1994; 4: 409-412.
Baron MH. Embryonic Erythroid Differentiation and Development. Symp. Eur. School Molec. Med. (Signal Transduction in Differentiation and Trans-Differentiation) 1994; Brescia, Italy.
Lister J, Forrester WC, Baron MH. Inhibition of an erythroid differentiation switch by the helix-loop-helix protein, Id1. J. Biol. Chem. 1995; 270: 17939-17946.
Dyer MA, Trepicchio WL, Belaoussoff M, Farrington SM, Baron MH. Molecular Mechanisms of Embryonic β-Like Globin Gene Regulation During Mammalian Development. 1995; Hemoglobin Switching, vol. 1, Intercept Ltd., pp. 135-151.
Dyer MA, Naidoo R, Hayes PJ, Larson CJ, Verdine GL, Baron MH. A DNA bending protein interacts with an essential upstream regulatory element of the human embryonic β-like globin gene. Mol. Cell. Biol. 1996; 16: 829-838.
Baron MH. Developmental Regulation of the Vertebrate Globin Multigene Family. Gene Expression. 1996; 6:129-137.
Farrington SM, Belaoussoff M, Baron MH. Winged helix, hedgehog, and Bmp genes are differentially restricted to functionally distinct tissue layers within the murine embryonic yolk sac. Mech. Develop. 1997; 62:197-211.
Baron MH. Transcriptional control of globin gene expression during vertebrate development. Biochim. Biophys. Acta. 1997; 1351: 51-72.
Lister J, Baron MH. Induction of basic-helix-loop-helix protein-containing complexes during erythroid differentiation. Gene Expression. 1998; 7:25-38.
Dyer MA, Hayes PJ, Baron MH. The HMG domain protein SSRP1/PREIIBF is involved in activation of the human embryonic β-like globin gene. Mol. Cell Biol. 1998; 18: 2617-2628.
Belaoussoff M, Farrington SM, Baron MH. Hematopoietic Induction and Respecification of A-P Identity by Visceral Endoderm Signaling in the Mouse Embryo. Development. 1998; 125:5009-5018.
Spencer JA, Baron, MH, Olson EN. Cooperative Transcriptional Activation by Serum Response Factor and the High Mobility Group Protein SSRP1. J. Biol. Chem. 1999; 274, 15686-15693.
Baron MH. Interaction of endoderm and ectoderm in embryonic hematopoiesis. Exper. Hematol. 2000; 28: 129.
Baron MH. Embryonic Induction of Mammalian Hematopoiesis and Vasculogenesis. In: L. Zon, ed. 2001; Hematopoiesis, Chapter 13, New York, Oxford University Press, pp. 160-170.
Dyer MA, Farrington SM, Mohn D Munday J, Baron MH. Indian Hedgehog Activates Hematopoiesis and Vasculogenesis and Can Respecify Prospective Neurectodermal Cell Fate in the Mouse Embryo. Development. 128: 1717-1730.
Baron MH. Induction of Embryonic Hematopoietic and Endothelial Stem/Progenitor Cells by Hedgehog-Mediated Signals. Differentiation. 2001; 69: 175-185.
Baron MH. Molecular Regulation of Embryonic Hematopoiesis and Vascular Development: A Novel Pathway. J. Hematother. Stem Cell Res.(now Stem Cells and Development) 2001; 10: 587-594.
Baron MH, Mitus AJ. Chapter 15: Blood Disorders. In: K. Carlson and S.A. Eisenstadt, eds. 2002; Primary Care of Women, 2nd Ed., St. Louis, Mosby-Year Book, Inc., pp. 142-150.
Sahr K, Dias D, Sanchez R, Chen D, Chen S, Gudas L, Baron MH. Structure, upstream promoter region, and functional domains of a mouse and human mix paired-like homeobox gene. Gene. 2002; 291: 135-147.
Baron MH. Activation of Hematopoiesis and Vasculogenesis in the Mouse Embryo: Induction and Reprogramming of Ectodermal Cell Fate by Signals from Primitive Endoderm. In: Eaton GR, Wiley DC, Jardetsky O. eds. 2002; Structures and Mechanisms: From Ashes to Enzymes (ACS Symposium Series), Vol. 827 (Washington, DC, American Chemical Society), pp. 294-308.
Jones EAV, Crotty D, Kulesa PM, Waters CW, Baron MH, Fraser SE, Dickinson ME. Dynamic In Vivo Imaging of Post-Implantation Mammalian Embryos Using Whole Embryo Culture. Genesis. 2002; 34: 228-235.
Mohn D, Chen S, Dias D, Weinstein D, Dyer MA, Sahr K, Ducker CE, Zahradka KE, Keller G, Zaret KS, Gudas L, Baron MH. The mouse Mix gene is activated early during differentiation of ES and F9 stem cells and induces endoderm in frog embryos. Developmental Dynamics. 2003; 226: 446-459.
Baron MH. Embryonic Origins of Mammalian Hematopoiesis. Experimental Hematology. 2003; 31: 1160-1169.
Baron MH. Hemangioblasts in Adults? ["Inside Blood"] Blood. 2004; 103: 1.
Jones EAV, Baron MH, Fraser SE, Dickinson ME. Measuring Hemodynamic Changes During Mammalian Development. Amer. J. Physiol. 2004; 287: H1561-H1569.
Snyder A, Fraser ST, Baron MH. Bone Morphogenetic Proteins in Vertebrate Hematopoietic Development. J. Cellular Biochem. 2004; 93: 224-232.
Baron MH. (ed.) Developmental Regulation of Hematopoiesis: Methods and Protocols. 2005; Methods in Molecular Medicine series, New York, Humana Press.
Jones EAV, Crotty D, Baron MH, Fraser SE, Dickinson ME. Dynamic In Vivo Imaging of Mammalian Hemato-Vascular Development Using Whole Embryo Culture. Developmental Regulation of Hematopoiesis: Methods and Protocols, ed. Baron MH. 2005; Methods in Molecular Medicine series, New York, Humana Press, pp. 381-393.
Baron MH, Mohn D. Mouse Embryonic Explant Culture System for Analysis of Hematopoietic and Vascular Development. In Developmental Regulation of Hematopoiesis: Methods and Protocols, ed. Baron MH. 2005; Methods in Molecular Medicine series, New York, Humana Press, pp. 231-256.
Baron MH, Fraser ST. The Specification of Early Hematopoiesis in the Mammal. I. Lemischka, ed. Current Opinion in Hematology. 2005; 12: 217-221.
Fraser ST, Hadjantonakis K, Willey S, Sahr KE, Kelly OG, Jones EAV, Dickinson ME, Baron MH. Using a Histone Yellow Fluorescent Protein Fusion for Tagging and Tracking Endothelial Cells in ES Cells and Mice. Genesis. 2005; 42: 162-171.
Baron MH. Early Patterning of the Mouse Embryo: Implications for Hematopoietic Commitment and Differentiation. Experimental Hematology. 2005; 33: 1015-1020.
Willey S, Ayuso-Sacido A, Zhang H, Fraser ST, Adlam MA, Sahr K, Kyba M, Daley GQ, Keller G, Baron MH. Acceleration of Mesoderm Development and Expansion of Hematopoietic Progenitors in Differentiating ES Cells by the Mouse Mix-Like Homeodomain Transcription Factor. Blood, First Edition Paper, prepublished online2006 January 10; DOI 10.1182/blood-2005-10-4120.
Kwon G, Fraser ST, Eakin G, Mangano M, Isern J, Sahr KE, Hadjantonakis AK, Baron MH. Tg(Afp-GFP) Expression Marks Primitive and Definitive Endoderm Lineages during Mouse Development. Developmental Dynamics. 2006; 235: 2549-2558. Epub ahead of press.
Fraser ST, Isern J, Baron MH. Maturation and enucleation of primitive erythroblasts is accompanied by changes in cell surface antigen expression patterns during mouse embryogenesis. Blood. 2007; 109: 343-352. First Edition Paper, August 29, 2006; DOI 10.1182/blood-2006-03-006569.
Haremaki T, Fraser ST, Kuo YM, Baron MH, Weinstein DC. Vertebrate Ctr1 coordinates morphogenesis and progenitor cell fate and regulates embryonic stem cell differentiation. Proc. Natl. Acad. Sci. USA 2007; 104: 12029-12034. Early Edition, 10.1073_pnas0701413104.
Durand C, Robin C, Bollerot K, Baron MH, Ottersbach K, Dzierzak E. AGM stromal clones reveal developmental regulators of definitive hematopoietic stem cells. Proc. Natl. Acad. Sci. USA in revision.
Isern, J., He, Z., Fraser, S.T. Nowotschin, S., Ferrer-Vaquer, A., Moore, R., Hadjantonakis, A.-K., Schulz, V., Tuck, D., Gallagher, P.G., and Baron, M.H. (2011) Single Lineage Transcriptome Analysis Reveals Key Regulatory Pathways in Primitive Erythroid Progenitors in the Mouse Embryo, Blood 117: 4924-4934. Cover article. See commentary "Inside Blood," Mullner, E. Erythropoiesis: early, not primitive. Blood 117: 4685-4686.
Artus, J., Douvaras, P., Piliszek, A., Isern, J., Baron, M.H., Hadjantonakis, A.-K. (2012) BMP signalling directs primitive endoderm-derived XEN cells to an extraembryonic visceral endoderm identity. Develop. Biol. 361: 245-262.
Baron, M.H., Isern, J. andFraser, S.(2012) The embryonicorigins of erythropoiesis in mammals.Blood, invited review, FIRST EDITION version in press.
United States and International Patents
Baron MH, Farrington SM, Belaoussoff M. "Methods of using hedgehog proteins to modulate hematopoiesis and vascular growth." U.S. Patent 6,713,065 B2, issued March 30, 2004. Assignee: President and Fellows of Harvard College. Licensed to Curis, Inc., Cambridge, MA.
International Patents pending
Canada, Europe, Japan.