Recognition and Publications

Yao S, Richards J, Belasco JG, Bechhofer DH. Decay of a model mRNA in Bacillus subtilis by a combination of RNase J1 5' exonuclease and RNase Y endonuclease activities. J Bacteriol. 2011 Nov;193(22):6384-6.

Deikus G, Bechhofer DH. 5' End-independent RNase J1 endonuclease cleavage of Bacillus subtilis model RNA. J Biol Chem. 2011 Oct 7;286(40):34932-40.

Richards J, Liu Q, Pellegrini O, Celesnik H, Yao S, Bechhofer DH, Condon C, Belasco JG. An RNA pyrophosphohydrolase triggers 5'-exonucleolytic degradation of mRNA in Bacillus subtilis. Mol Cell. 2011 Sep 16;43(6):940-9.

Bechhofer DH. Bacillus subtilis mRNA decay: new parts in the toolkit. Wiley Interdiscip Rev RNA. 2011 May;2(3):387-94.

Condon C, Bechhofer DH. Regulated RNA stability in the Gram positives. Curr Opin Microbiol. 2011 Apr;14(2):148-54.

Yao S, Bechhofer DH. Initiation of decay of Bacillus subtilis rpsO mRNA by endoribonuclease RNase Y. J Bacteriol. 2010 Jul;192(13):3279-86.

Bechhofer DH. Messenger RNA degradation in bacteria. Elsevier Encyclopedia of Biological Chemistry, 2nd edition. 2010.

Yao S, Sharp JS, Bechhofer DH. Bacillus subtilis RNase J1 endonuclease and 5' exonuclease activities in the turnover of DeltaermC mRNA. RNA. 2009 Dec;15(12):2331-9.

Deikus G, Bechhofer DH. Bacillus subtilis trp Leader RNA: RNase J1 endonuclease cleavage specificity and PNPase processing. J Biol Chem. 2009 Sep 25;284(39):26394-401.

Yao S, Bechhofer DH. Processing and stability of inducibly expressed rpsO mRNA derivatives in Bacillus subtilis.J Bacteriol. 2009 Sep;191(18):5680-9.

Cardenas PP, Carrasco B, Sanchez H, Deikus G, Bechhofer DH, Alonso JC. Bacillus subtilis polynucleotide phosphorylase 3'-to-5' DNase activity is involved in DNA repair. Nucleic Acids Res. 2009 Jul;37(12):4157-69.

Bechhofer DH. Messenger RNA decay and maturation in Bacillus subtilis. Prog Mol Biol Transl Sci. 2009;85:231-73.

Yao S, Blaustein JB, Bechhofer DH. Erythromycin-induced ribosome stalling and RNase J1-mediated mRNA processing in Bacillus subtilis. Mol Microbiol. 2008 Sep;69(6):1439-49.

Deikus G, Condon C, Bechhofer DH. Role of Bacillus subtilis RNase J1 endonuclease and 5'-exonuclease activities in trp leader RNA turnover. J Biol Chem. 2008 Jun 20;283(25):17158-67.

Redko Y, Bechhofer DH, Condon C. Mini-III, an unusual member of the RNase III family of enzymes, catalyses 23S ribosomal RNA maturation in B. subtilis. Mol Microbiol. 2008 Jun;68(5):1096-106.

Tardos JG, Eisenreich A, Deikus G, Bechhofer DH, Chandradas S, Zafar U, Rauch U, Bogdanov VY. SR proteins ASF/SF2 and SRp55 participate in tissue factor biosynthesis in human monocytic cells. J Thromb Haemost. 2008 May;6(5):877-84.

Bechhofer DH, Oussenko IA, Deikus G, Yao S, Mathy N, Condon C. Analysis of mRNA decay in Bacillus subtilis. Methods Enzymol. 2008;447:259-76.

Condon C, Pellegrini O, Mathy N, Benard L, Redko Y, Oussenko IA, Deikus G, Bechhofer DH. Assay of Bacillus subtilis ribonucleases in vitro. Methods Enzymol. 2008;447:277-308.

Yao S, Blaustein JB, Bechhofer DH. Processing of Bacillus subtilis small cytoplasmic RNA: evidence for an additional endonuclease cleavage site. Nucleic Acids Res. 2007;35(13):4464-73.

Deikus G, Bechhofer DH. Initiation of decay of Bacillus subtilis trp leader RNA.J Biol Chem. 2007 Jul 13;282(28):20238-44.

Wei Y, Deikus G, Powers B, Shelden V, Krulwich TA, Bechhofer DH. Adaptive gene expression in Bacillus subtilis strains deleted for tetL. J Bacteriol. 2006 Oct;188(20):7090-100.

Campos-Guillen J, Bralley P, Jones GH, Bechhofer DH, Olmedo-Alvarez G. Addition of Poly(A) and Heteropolymeric 3' Ends in Bacillus subtilis Wild-Type and Polynucleotide Phosphorylase-Deficient Strains. J Bacteriol. 2005 Jul;187(14):4698-706.

Wen T, Oussenko IA, Pellegrini O, Bechhofer DH, Condon C. Ribonuclease PH plays a major role in the exonucleolytic maturation of CCA-containing tRNA precursors in Bacillus subtilis. Nucleic Acids Res. 2005 Jun;33(11):3636-43.

Sharp JS, Bechhofer DH. Effect of 5'-proximal elements on decay of a model mRNA in Bacillus subtilis. Mol Microbiol. 2005 Jul;57(2):484-95.

Oussenko IA, Abe T, Ujiie H, Muto A, Bechhofer DH. Participation of 3'-to-5' exoribonucleases in the turnover of Bacillus subtilis mRNA. J Bacteriol. 2005 Apr;187(8):2758-67.

Oussenko IA, Sanchez R, Bechhofer DH. Bacillus subtilis YhcR, a high-molecular-weight, nonspecific endonuclease with a unique domain structure. J Bacteriol. 2004 Aug;186(16):5376-83.

Deikus G, Babitzke P, Bechhofer DH. Recycling of a regulatory protein by degradation of the RNA to which it binds. Proc Natl Acad Sci USA. 2004 Mar;101(9):2747-51.

Hicks DB, Wang Z, Wei Y, Kent R, Guffanti AA, Banciu H, Bechhofer DH, Krulwich TA. A tenth atp gene and the conserved atpI gene of a Bacillus atp operon have a role in Mg 2+ uptake. Proc Natl Acad Sci USA. 2003 Sep;100(18):10213-8.

Sharp JS, Bechhofer DH. Effect of translational signals on mRNA decay in Bacillus subtilis. J Bacteriol. 2003 Sep;185(18):5372-9.

Oussenko IA, Sanchez R, Bechhofer DH. Bacillus subtilis YhaM, a member of a new family of 3'-to-5' exonucleases in Gram-positive bacteria. J Bacteriol. 2002 Nov;184(22):6250-9.

Drider D, DiChiara JM, Wei J, Sharp JS, Bechhofer DH. Endonuclease cleavage of messenger RNA in Bacillus subtilis. Mol Microbiol. 2002 Mar;43(5):1319-29.

Wei Y, Bechhofer DH. Tetracycline induces stabilization of mRNA in Bacillus subtilis. J Bacteriol. 2002 Feb; 184(4):889-94.

Krulwich TA, Jin J, Guffanti AA, Bechhofer DH. Functions of tetracycline efflux proteins that do not involve tetracycline. J Mol Micro Biotechnol. 2001 Apr;3(2):237-46.

Herskovitz MA, Bechhofer DH. Endoribonuclease RNase III is essential in Bacillus subtilis. Mol Microbiol. 2000 Dec;38(5):1027-33.


Contact Us

David Bechhofer, PhD
Tel: 212-241-5628
Fax: 212-996-7214

Annenberg Building
19th Floor, Room 19-98
Pharmacology and Systems Therapeutics
1468 Madison Avenue
New York NY, 10029