Publications

O'Brien M, Montenont E, Hu L, Nardi MA, Valdes V, Merolla M, Gettenberg G, Cavanagh K, Aberg JA, Bhardwaj N, Berger JS. Aspirin attenuates platelet activation and immune activation in HIV-infected subjects on antiretroviral therapy: A Pilot Study. J Acquir Immune Defic Syndr. 2013

Ott P, Henry T, Jimenez S, Frleta D, Manches O, Bogunovic D, Bhardwaj N. 2013. Inhibition of both BRAF and MEK in BRAFV600E melanoma rescues compromised Dendritic Cell (DC) function while having differential direct effects on DC properties. Cancer Immunology Immunotherapy. 62: 811-822.

O’Brien M, Manches O, Bhardwaj N. Plasmacytoid dendritic cells in HIV infection, Adv Exp Med Biol. 2013;762:71-107

D. Frleta, C.E. Ochoa, H. Kramer, B. Kessler, B. Haynes, N. Bhardwaj. 2012. HIV-1 infection- induced apoptotic microparticles inhibit human dendritic cells via CD44. Journal of Clinical Investigation. 122: 4685-4697.

Miller EA, Spadaccia MR, O’Brien MP, Rolnitzky L, Manches O, Frleta D, Bhardwaj N. 2012. Plasma factors during chronic HIV-1 infection impair IL-12 secretion by myeloid dendritic cells via a virus-independent pathway. Journal of AIDS. 61: 535-544.

Jiménez-Baranda S, Silva IP, Bhardwaj N. Plasmacytoid dendritic cells lead the charge against tumors. J Clin Invest. 2012 Feb 1;122:481-484

Godefroy E and Bhardwaj N. Dysregulation of anti-tumor immunity by the matrix metalloproteinase-2. 2012. OncoImmunology. 1:109-111.

Manches O, Fernandez MV, Plumas J, Chaperot L, Bhardwaj N. Activation of the noncanonical NF-κB pathway by HIV controls a dendritic cell immunoregulatory phenotype. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14122-7x

O'Brien M, Markowitz M.  Should we treat acute HIV infection? Curr HIV/AIDS Rep. 2012 Jun;9(2):101-10.

Altfeld M, Fadda L, Frleta D, Bhardwaj N. 2011. DCs and NK cells: critical effectors in the immune response to HIV-1. Nature Reviews Immunology. 11: 176-186.

Bogunovic D, Manches O, Godefroy E, Gallois A, Yewdall A, Schloss J, Salazar AM, Marie I, Levy DE and Bhardwaj N. Simultaneous TLR4 engagement inhibits TLR3-induced proinflammatory signaling in dendritic cells through IL-10 and p38-dependent pathways and limits CD8+ T cell priming. 2011. Cancer Res. 71:5467-5476.

Sunseri N, O'Brien M, Bhardwaj N, Landau NR. Human immunodeficiency virus type 1 modified to package Simian immunodeficiency virus Vpx efficiently infects macrophages and dendritic cells. J Virol. 2011 Jul;85(13):6263-74.

Godefroy E, Manches O, Dréno B, Hochman T, Rolnitzky L, Labarrière N, Guilloux Y, Goldberg J, Jotereau F and Bhardwaj N. Matrix metalloprotease-2 conditions human dendritic cells to prime inflammatory TH2 CD4+ T cells via an IL-12 and OX40L-dependent pathway. 2011. Cancer Cell. 19:333-346.

O’Brien M, Manches O, Lubong Sabado R, Jimenez Baranda S, Wang Y, Levy D, Bhardwaj N. Spatiotemporal trafficking of HIV in plasmacytoid dendritic cells defines a persistently IFNa-producing and partially matured phenotype. J Clin Invest. 2011; 121(3):1088

Jimenez-Baranda S, Manches O, Greenbaum B, Levine A, Bharwdaj N. Oligonucleotide Motifs That Disappear During the Evolution of Influenza in Humans Increase IFN-{alpha} secretion by Plasmacytoid Dendritic Cells. J Virol. 2011; 85(8):3893

Sabado RL, O'Brien M, Subedi A, Qin L, Hu N, Taylor E, Dibben O, Stacey A, Fellay J, Shianna KV, Siegal F, Shodell M, Shah K, Larsson M, Lifson J, Nadas A, Marmor M, Hutt R, Margolis D, Garmon D, Markowitz M, Valentine F, Borrow P, Bhardwaj N. Evidence of dysregulation of dendritic cells in primary HIV infection. Blood. 2010 Nov 11;116(19):3839-52.

Gallois A, Bhardwaj N. A needle in the 'cancer vaccine' haystack. Nat Med. 2010 Aug;16:854-856

Renaud V, Godefroy E, Larrieu P, Jotereau F and Guilloux Y. Folding of matrix metalloprotease-2 prevents endogenous generation of MHC class-I epitope. 2010. PLoS ONE. 5:e11894.

Frleta D, Yu CI, Klechevsky E, Flamar AL, Zurawski G, Banchereau J, Palucka AK. 2009. Influenza Virus and Poly(I:C) Inhibit MHC Class I-Restricted Presentation of Cell-Associated Antigens Derived from Infected Dead Cells Captured by Human Dendritic Cells. Journal of Immunology 182: 2766-2776.

Manches O, Bhardwaj N. Resolution of immune activation defines nonpathogenic SIV infection. J Clin Invest 2009 Dec;119(12):3512-5.

Manches O, Munn D, Fallahi A, Lifson J, Chaperot L, Plumas J, Bhardwaj N. HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase-dependent mechanism. J Clin Invest. 2008 Oct;118(10):3431-9

Saito H, Frleta D, Dubsky P, Palucka AK. 2006. Dendritic cell-based vaccination against cancer. Hematology/Oncology clinics of North America. 20: 689-710

Beignon AS, McKenna K, Skoberne M, Manches O, DaSilva I, Kavanagh DG, Larsson M, Gorelick RJ, Lifson JD, Bhardwaj N. Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions. J Clin Invest. 2005 Nov;115(11):3265-75.

Godefroy E, Moreau-Aubry A, Diez E, Dreno B, Jotereau F and Guilloux Y. αvβ3-dependent cross-presentation of matrix metalloproteinase-2 by melanoma cells gives rise to a new tumor antigen recognized by CD8+ tumor infiltrating T cells. 2005. J. Exp. Med. 202:61-72.

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