Publications

Birtwistle MR, Kriegsheim Av, Dobrzyński M, Kholodenko BN, Kolch W. Mammalian protein expression noise: scaling principles and the implications for knockdown experiments. Mol Biosyst. 2012 Oct 2;8(11):3068-76 | Supplemental Files

Birtwistle MR, Rauch J, Kiyatkin A, Aksamitiene E, Dobrzy 324 Ski M, Hoek JB, Kolch W, Ogunnaike BA, Kholodenko BN. Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise. BMC Syst Biol. 2012 Aug 24;6(1):109 | Supplemental Files

von Thun A, Birtwistle M, Kalna G, Grindlay J, Strachan D, Kolch W, von Kriegsheim A, Norman JC. ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-β2. J Cell Sci. 2012 Mar 15;125(Pt 6):1465-77.

Birtwistle MR, von Kriegsheim A, Kida K, Schwarz JP, Anderson KI, Kolch W. Linear approaches to intramolecular Förster resonance energy transfer probe measurements for quantitative modeling. PLoS One. 2011;6(11):e27823.

Matallanas D, Birtwistle M, Romano D, Zebisch A, Rauch J, von Kriegsheim A, Kolch W. Raf family kinases: old dogs have learned new tricks. Genes Cancer. 2011 Mar;2(3):232-60.

Birtwistle MR, Kolch W. Biology using engineering tools: the negative feedback amplifier. Cell Cycle. 2011 Jul 1;10(13):2069-76.

Sturm OE, Orton R, Grindlay J, Birtwistle M, Vyshemirsky V, Gilbert D, Calder M, Pitt A, Kholodenko B, Kolch W. The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier. Sci Signal. 2010 Dec 21;3(153):ra90 | Supplemental Files

Nakakuki T, Birtwistle MR, Saeki Y, Yumoto N, Ide K, Nagashima T, Brusch L, Ogunnaike BA, Okada-Hatakeyama M, Kholodenko BN. Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics. Cell. 2010 May 28;141(5):884-96 | Supplemental Files

Kholodenko BN, Birtwistle MR. Four-dimensional dynamics of MAPK information processing systems. Wiley Interdiscip Rev Syst Biol Med. 2009 Jul-Aug;1(1):28-44.

von Kriegsheim A, Baiocchi D, Birtwistle M, Sumpton D, Bienvenut W, Morrice N, Yamada K, Lamond A, Kalna G, Orton R, Gilbert D, Kolch W. Cell fate decisions are specified by the dynamic ERK interactome. Nat Cell Biol. 2009 Dec;11(12):1458-64 | Supplemental Files

Birtwistle MR, Kholodenko BN. Endocytosis and signalling: a meeting with mathematics. Mol Oncol. 2009 Aug;3(4):308-20.

Birtwistle MR, Hatakeyama M, Yumoto N, Ogunnaike BA, Hoek JB, Kholodenko BN. Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses. Mol Syst Biol. 2007;3:144 | Supplemental Files


Contact Us

Marc Birtwistle PhD
Tel: 212-241-2051
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Annenberg Building
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Floor 19 Room 19-80A
One Gustave L. Levy Place
Box 1603
New York, NY 10029