Projects and Grants

Regulation of adipose tissue metabolism by central leptin and insulin

The overall goal of this project is to delineate the role of central insulin and to extend studies into the role of central leptin signaling in regulating WAT metabolism.

ADA research award          (Buettner, PI)       (2009-2011)

The role of AgRP and POMC neurons in regulating adipose tissue metabolism through leptin and insulin

Here we wish to define the role of insulin and leptin signaling in Agrp/NPY and Pomc neurons in regulating WAT metabolism. Our overall goal is to delineate the role of central insulin and to extend studies into the role of central leptin signaling in regulating WAT metabolism.

NIH RO3 DK082724           (Buettner, PI) (2009-2010)

The role of the endocannabinoid system in regulating hepatic glucose fluxes

The two aims of this proposal are to delineate the role of central EC signaling in the regulation of hepatic glucose production, and to investigate if hypothalamic EC levels can be modulated by ECs that originate from adipose tissue. These studies should advance our understanding of why excessive nutrient intake leads to increased EC tone and impaired brain control of metabolism in adipose tissue and liver.

NIH KO8 DK074873           (Buettner, PI) (2007-2010)

The role of Stat3 in mediating the pleiotropic effects of leptin

The aim of this proposal is to delineate the contributions of hypothalamic leptin signaling in controlling adipocyte metabolism. These studies should lead to a better understanding of the basic biological processes by which central pathways regulate body adiposity independently of food intake.

NIH P41RR018522-07       (Smith, PI) (2009-2010)

Proteomic study of hepatic metabolism regulated by hypothalamic pathways This subproject aims to understand how the medio-basal hypothalamus (MBH) regulates hepatic glucose and lipid homeostasis by identifying key molecular pathways in liver tissue through proteomic analysis.

Role: Co-PI

Pilot and feasibility award from the Department of Environmental Medicine, Mount Sinai: Role of environmental toxicants in the metabolic syndrome (LaMerill and Buettner, PI). The aim is to study the role of PCBs and other toxicants that are ubiquitous in the environment and are man made in the metabolic syndrome and obesity.


Contact Us

Christoph Buettner MD, PhD
Tel: 212-241-3425
Fax: 212-241-4218
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Atran Berg Laboratory Building
Room 4-23
1428 Madison Avenue
Box 1055
New York, NY 10029