Clinical Trials

Minimally Invasive Surgery Plus rtPA for Intracerebral Hemorrhage Evacuation (MISTIE)
The purpose of this trial is to determine the safety of using a combination of minimally invasive surgery and clot lysis with rt-PA to remove intracerebral hemorrhage (ICH). The procedure is to use image-based surgery (MRI or CT) to provide catheter access to ICH for the intervention, which is a one-time clot aspiration followed by instillation of rt-PA over 72 hours. We propose to test if this intervention facilitates more rapid and complete recovery of function and decreased mortality from this condition compared to conventional medical management without subjecting the patient to craniotomy. In addition the proposed study results will provide the first estimates of the relation between initial disease severity and long-term outcome for ICH.